Shangqin Guo, PhD

Assistant Professor of Cell Biology

Research Interests

Cell Biology; Hematopoietic Stem Cells; Cellular Reprogramming

Research Organizations

Cell Biology

Stem Cell Center, Yale

Yale Cancer Center: Genomics, Genetics, and Epigenetics

Office of Cooperative Research

Research Summary

We are interested in learning the cell fate decision processes: how does a cell know what to be and what not to be? We use three biological model systems to investigate this question. 1) Induced pluripotency (Yamanaka reprogramming). 2) Malignant transformation. 3) Hematopoietic stem cell emergence and maintenance. The long term goal of understanding the rules of cell fate decision making is to create desired cell types for cell replacement therapies and to eliminate the emergence of harmful cell types such as cancer.

Specialized Terms: Cell fate control; Reprogramming; Hematopoietic stem and progenitors; Leukemogenesis; Cell cycle; live-cell imaging

Full List of PubMed Publications

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Contact Info

Shangqin Guo, PhD
Mailing Address
Cell Biology10 Amistad St.
New Haven, CT 06520-8005

Guo lab

Research Image 1

Growing colonies during Yamanaka reprogramming captured by live-cell imaging. Green color indicates pluripotency (Oct4:GFP). Red color indicates G1 cell cycle phase (FUCCI).