Caihong Qiu, PhD

Research Interests

Cell Biology; Embryonic Stem Cells

Research Organizations

Faculty Research

Stem Cell Center, Yale: Stem Cell Genetics | Transcriptional Regulation of Stem and Progenitor Cells

Research Summary

We are interested in understanding the mechanism of human embryonic stem cell self-renewal and directing hESCs differentiation down to specific lineages.

Specialized Terms: Human embryonic stem cells (hESCs); Hematopoiestic differentiation of hESCs; Neuronal differentiation of hESCs

Selected Publications

• Complex developmental patterns of histone modifications associated with the human beta-globin switch in primary cells.

  Hsu M, Richardson CA, Olivier E, Qiu C, Bouhassira EE, Lowrey CH, Fiering S. Complex developmental patterns of histone modifications associated with the human beta-globin switch in primary cells. Exp Hematol. 2009 Jul;37(7):799-806.e4

• Developmentally regulated extended domains of DNA hypomethylation encompass highly transcribed genes of the

  Melissa J. Lathrop, Mei Hsu, Christine A. Richardson, Emmanuel N. Olivier, Caihong Qiu, Eric E. Bouhassira, Steven Fiering, Christopher H. Lowrey Developmentally regulated extended domains of DNA hypomethylation encompass highly transcribed genes of the

• Role for MKL1 in megakaryocytic maturation

  Ee-chun cheng, Qing luo, Emanuela M. Bruscia, Matthew J. Renda, James A. Troy, Stephanie A. Massaro, David Tuck, Vincent Schulz, Shrikant M. Mane, Nancy Berliner, Yi Sun, Stephan W. Morris, Caihong Qiu, and Diane S Krause .Role for MKL1 in megakaryocytic maturation 2009 Blood 113 (12) 2826-2834.

• Globin switches in yolk sac-like primitive and fetal-like definitive red blood cells produced from human embryonic stem cells.

  Qiu C, Olivier EN, Velho M, Bouhassira EE. Globin switches in yolk sac-like primitive and fetal-like definitive red blood cells produced from human embryonic stem cells. Blood. 2008 Feb 15;111(4):2400-8

• Large-scale production of embryonic red blood cells from human embryonic stem cells.

  Olivier EN, Qiu C, Velho M, Hirsch RE, Bouhassira EE. Large-scale production of embryonic red blood cells from human embryonic stem cells. Exp Hematol. 2006 Dec;34(12):1635-42.

• Differentiation of human embryonic stem cells into hematopoietic cells by coculture with human fetal liver cells recapitulates the globin switch that occurs early in development.

  Qiu C, Hanson E, Olivier E, Inada M, Kaufman DS, Gupta S, Bouhassira EE. Differentiation of human embryonic stem cells into hematopoietic cells by coculture with human fetal liver cells recapitulates the globin switch that occurs early in development. Exp Hematol. 2005 Dec;33(12):1450-8.

Full List of PubMed Publications

• Dash BC, Levi K, Schwan J, Luo J, Bartulos O, Wu H, Qiu C, Yi T, Ren Y, Campbell S, Rolle MW, Qyang Y: Tissue-Engineered Vascular Rings from Human iPSC-Derived Smooth Muscle Cells. Stem Cell Reports. 2016 Jul 12. PMID: 27411102
• Hysolli E, Tanaka Y, Su J, Kim KY, Zhong T, Janknecht R, Zhou XL, Geng L, Qiu C, Pan X, Jung YW, Cheng J, Lu J, Zhong M, Weissman SM, Park IH: Regulation of the DNA Methylation Landscape in Human Somatic Cell Reprogramming by the miR-29 Family. Stem Cell Reports. 2016 Jul 12; 2016 Jun 30. PMID: 27373925
• Guo Y, Liu J, Elfenbein SJ, Ma Y, Zhong M, Qiu C, Ding Y, Lu J: Characterization of the mammalian miRNA turnover landscape. Nucleic Acids Res. 2015 Feb 27; 2015 Feb 4. PMID: 25653157
• Sundaram S, Echter A, Sivarapatna A, Qiu C, Niklason L: Small-diameter vascular graft engineered using human embryonic stem cell-derived mesenchymal cells. Tissue Eng Part A. 2014 Feb. PMID: 24125588
• Peng S, Gan G, Qiu C, Zhong M, An H, Adelman RA, Rizzolo LJ: Engineering a blood-retinal barrier with human embryonic stem cell-derived retinal pigment epithelium: transcriptome and functional analysis. Stem Cells Transl Med. 2013 Jul; 2013 Jun 3. PMID: 23734062
• Ma Y, Lin H, Qiu C: High-efficiency transfection and siRNA-mediated gene knockdown in human pluripotent stem cells. Curr Protoc Stem Cell Biol. 2012 May. PMID: 22605647
• Ma Y, Jin J, Dong C, Cheng EC, Lin H, Huang Y, Qiu C: High-efficiency siRNA-based gene knockdown in human embryonic stem cells. RNA. 2010 Dec; 2010 Oct 26. PMID: 20978109
• Qiu C, Ma Y, Wang J, Peng S, Huang Y: Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells. Nucleic Acids Res. 2010 Mar; 2009 Dec 4. PMID: 19966271
• Cheng EC, Luo Q, Bruscia EM, Renda MJ, Troy JA, Massaro SA, Tuck D, Schulz V, Mane SM, Berliner N, Sun Y, Morris SW, Qiu C, Krause DS: Role for MKL1 in megakaryocytic maturation. Blood. 2009 Mar 19; 2009 Jan 9. PMID: 19136660

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