Antonio J. Giraldez, PhD

Fergus F. Wallace Professor of Genetics; Chair, Genetics

Research Interests

Autistic Disorder; Zebrafish; Developmental Biology; Gene Expression Regulation, Developmental; Computational Biology; Genomics; Systems Biology

Public Health Interests


Research Organizations

Center for RNA Science and Medicine, Yale

Gene Regulation and Functional Genomics

Stem Cell Center, Yale

Yale Cancer Center: Genomics, Genetics, and Epigenetics

Research Summary

In our laboratory we investigate how gene regulation shapes vertebrate embryonic development using zebrafish as a model system. We combine genomics, genetics, embryology, chemical and computational biology to address a central question in biology: how does a fertilized egg develop into a complex multicellular embryo. This process requires a precise spatial and temporal regulation of gene expression. We are primarily focused on understanding the mechanisms that activate the genome soon after fertilization and how this universal transition drives post-transcriptional regulation of the maternal instructions to allow one of the central developmental transitions to occur. Our research is focusing in four main areas: Analysis of Genome activation, mechanisms of post-transcriptional regulation, computational modeling of gene expression and animal models to understand autism.

Selected Publications

Full List of PubMed Publications

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