Several postdoctoral associate/fellow positions are available in Dr. Andrew Xiao’s lab (Yale Stem Cell Center and Department of Genetics). We focus on characterizing unique cellular and molecular features of pluripotent stem cells (PSCs) and the underlying epigenetic mechanisms (Dan et al., Developmental cell 29, 7-19, 2014; Wu et al. Cell stem cell 15, 281-294, 2014). We are credited with the recent discovery of a novel DNA modification, N6-methyladeine, in mammals (Nature 532, 329–333, 2016). Our ongoing research encompasses: (1) novel DNA modifications in mammals, their modification machineries and effector binding proteins; (2) novel chromatin/histone mechanisms underlying preimplantation embryo development and cellular reprogramming; and (3) the functions of these novel epigenetic mechanisms in early embryogenesis and adult tissue stem cells, and in human diseases.
- Well-trained in at least one of the following: biochemistry and molecular biology, cell and developmental biology or genomics, epigenetics and bioinformatics/computational biology. The scholarship of the candidates must be well-demonstrated by a solid publication record, as well as the ability to tackle challenging research problems.
- Ability to lead an independent research direction while adapting to a collaborative and stimulating environment.
- As our investigation often involves developing innovative experimental and computational approaches, candidates are expected to acquire new concepts and research skills quickly.
- An innovative and critical thinker.
Candidates with following research experiences are highly encouraged to apply:
- Pre-implantation embryos (Zygotic to blastocyst stage) and cellular reprogramming
- Germ cells
- Neural development
- Immunology and infection diseases
- Human and primate ESC and/or iPSCs
- Genomics and bioinformatics
- Epigenetics, including small RNAs and chromatin biology
- Nuclear cell biology and super-resolution imaging
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