Yale Stem Cell Center is pleased to announce the seventh year of “The Lo Graduate Fellowship for Excellence in Stem Cell Research” for outstanding senior graduate students pursuing stem cell research at Yale University. This one-year fellowship ($22,750 for each fellow) is made possible by a generous gift of endowment from the K.S. & Feili Lo Foundation. It is Yale Stem Cell Center’s most prestigious graduate award, and is designed to recognize and support graduate students with demonstrated passion and achievement in stem cell research. Three awards are given each year to partially defray each recipient’s stipend, with funding beginning on September 1, 2018.
Anna Baccei, graduate student in the laboratory of Shangqin Guo in the Department of Cell Biology, is working on the development of a new fluorescence-based reporter to measure cell cycle speed in live cells with a single snapshot.
Bomiao Hu, graduate student in the laboratory of Katerina Politi in the Department of Pathology, is investigating the mechanisms of drug tolerance using mouse models of mutant EGFR-driven lung cancer.
Benjamin Patterson, graduate student in the laboratory of In-Hyun Park in the Department of Genetics, is using stem cells to model how humans regulate X chromosomes in early development and how this process can fail outside of the body.
Xinyue ChenXinyue Chen, graduate student in the laboratory of Shangqin Guo in the Department of Cell Biology, is using mouse leukemia model to identify and understand cellular behaviors important for cancer formation.
Kaixuan LinKaixuan Lin, graduate student in the laboratory of Andrew Xiao in the Department of Genetics, is conducting research to understand how histone variants and DNA modifications interplay to regulate stem cell pluripotency.
Allison WingAllison Wing, graduate student in the laboratory of Matt Rodeheffer in Comparative Medicine, is elucidating the mechanism of adipocyte stem cell proliferation and differentiation in response to dietary fatty acids.
Catherine "Cassie" McManusCatherine "Cassie" McManus, graduate student in the laboratory of Valerie Reinke in the Department of Genetics, is conducting research on deciphering the mechanisms that protect germ cells from somatic differentiation and that regulate their progression to a totipotent zygote.
Yumiko TaguchiYumiko Taguchi, graduate student in the laboratory of Sreenganga Chandra in the Department of Cell Biology, is using hESC and iPSC stem cell models to investigate the relationship between Gaucher and Parkinson's Diseases.
Charles HernandezHernandez, graduate student in the laboratory of Natalia Ivanova in the Department of Genetics completed his fellowship conducting research on the epigenetic mechanisms that govern transcription factor reprogramming, specifically the proteins of Dppa2/4 family and their role in enhancing cellular reprogramming.
Christine RodenRoden, graduate student in the laboratory of Jun Lu in the Department of Genetics completed her fellowship conducting research to understand the regulation of miR-125 family and by extension an important target gene, TET2, in the hematopoietic system.
Meng ZhangZhang, graduate student in the laboratory of Haifan Lin in the Department of Cell Biology completed her fellowship while studying the regulation of mouse neural stem cells by pumilio proteins.
Elise Jeffery, a student in the laboratory of Matthew Rodeheffer in the Section of Comparative Medicine and the Department of Molecular, Cellular and Developmental Biology, was selected for her work on the cellular and molecular mechanisms by which resident adipocyte precursor cells respond to high fat diet. Elise’s work identified that adipocyte stem cells are activated to increase adipocyte number in obesity by a mechanism that is distinct from adipocyte formation during development. This is a major advance in the obesity field and our understanding of the mechanisms that lead to weight gain.
Rachel Zwick, a student in the laboratory of Valerie Horsley in the Department of Molecular, Cellular and Developmental Biology, was selected for her work on a fundamental question of how adipocytes grow and shrink, which occurs during obesity and in other tissues such as the skin. Rachel developed a novel proposal that would employ techniques the laboratory developed to analyze adipocytes in the skin and the power of mouse genetics to lineage trace adipocyte lineage cells in the mammary gland. These studies have implications for multiple tissues where adipocytes reside and may have implications for mammary gland biology during pregnancy and tumorigenesis.