2023
Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport
Ozturk B, Koundal S, Al Bizri E, Chen X, Gursky Z, Dai F, Lim A, Heerdt P, Kipnis J, Tannenbaum A, Lee H, Benveniste H. Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport. JCI Insight 2023, 8: e170270. PMID: 37159262, PMCID: PMC10371231, DOI: 10.1172/jci.insight.170270.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressurePositive airway pressureGlymphatic transportAirway pressureIntracranial pressureEnd-expiratory lung volumeCSF bulk flowCerebrospinal fluid flowArterial oxygenationUpper airwayLung volumeCPAP deviceRespiratory functionClearance functionTherapeutic benefitSkull baseAnesthetized rodentsCSF flowFluid homeostasisPhysiological testingLymphatic systemFunctional crosstalkClinical devicesAirwayRats
2020
Midline Thalamic Damage Associated with Alcohol-Use Disorders: Disruption of Distinct Thalamocortical Pathways and Function
Savage LM, Nunes PT, Gursky ZH, Milbocker KA, Klintsova AY. Midline Thalamic Damage Associated with Alcohol-Use Disorders: Disruption of Distinct Thalamocortical Pathways and Function. Neuropsychology Review 2020, 31: 447-471. PMID: 32789537, PMCID: PMC7878584, DOI: 10.1007/s11065-020-09450-8.Peer-Reviewed Original ResearchConceptsAlcohol-related brain damageBrain damageAlcohol use disorderMidline thalamusAlcohol-related cognitive dysfunctionCognitive dysfunctionDistinct thalamocortical pathwaysAlcohol-related damageLoss of neuronsThalamo-cortical circuitsDevelopmental ethanol exposureBehavioral outcomesCognition functionCentral brain structuresBehavioral interventionsLimbic nucleiThalamic pathologyThalamocortical pathwaysEthanol exposureThalamic damageUse disordersAnimal modelsThalamusBrain structuresFlexible adaptation