2022
Rat Model of Late Gestational Alcohol Exposure Produces Similar Life-Long Changes in Thalamic Nucleus Reuniens Following Moderate- Versus High-Dose Insult
Gursky ZH, Klintsova AY. Rat Model of Late Gestational Alcohol Exposure Produces Similar Life-Long Changes in Thalamic Nucleus Reuniens Following Moderate- Versus High-Dose Insult. Alcohol And Alcoholism 2022, 57: 413-420. PMID: 35258554, PMCID: PMC9270984, DOI: 10.1093/alcalc/agac008.Peer-Reviewed Original ResearchConceptsBrain growth spurtBlood alcohol concentrationPeak blood alcohol concentrationAlcohol exposureThalamic nucleus reuniensRat modelNucleus reuniensSubstantial neuron lossBinge alcohol exposureFetal alcohol spectrum disordersGestational alcohol exposureNon-neuronal cellsLife-long changesAlcohol spectrum disordersNeuron lossIntragastric intubationRat pupsThalamic damageAE groupBehavioral alterationsCell lossLow dosesPrefrontal cortexUnbiased stereological estimationGrowth spurt
2020
Midline Thalamic Damage Associated with Alcohol-Use Disorders: Disruption of Distinct Thalamocortical Pathways and Function
Savage LM, Nunes PT, Gursky ZH, Milbocker KA, Klintsova AY. Midline Thalamic Damage Associated with Alcohol-Use Disorders: Disruption of Distinct Thalamocortical Pathways and Function. Neuropsychology Review 2020, 31: 447-471. PMID: 32789537, PMCID: PMC7878584, DOI: 10.1007/s11065-020-09450-8.Peer-Reviewed Original ResearchConceptsAlcohol-related brain damageBrain damageAlcohol use disorderMidline thalamusAlcohol-related cognitive dysfunctionCognitive dysfunctionDistinct thalamocortical pathwaysAlcohol-related damageLoss of neuronsThalamo-cortical circuitsDevelopmental ethanol exposureBehavioral outcomesCognition functionCentral brain structuresBehavioral interventionsLimbic nucleiThalamic pathologyThalamocortical pathwaysEthanol exposureThalamic damageUse disordersAnimal modelsThalamusBrain structuresFlexible adaptation