2021
Changes in Representation of Thalamic Projection Neurons within Prefrontal-Thalamic-Hippocampal Circuitry in a Rat Model of Third Trimester Binge Drinking
Gursky ZH, Klintsova AY. Changes in Representation of Thalamic Projection Neurons within Prefrontal-Thalamic-Hippocampal Circuitry in a Rat Model of Third Trimester Binge Drinking. Brain Sciences 2021, 11: 323. PMID: 33806485, PMCID: PMC8001051, DOI: 10.3390/brainsci11030323.Peer-Reviewed Original ResearchFetal alcohol spectrum disordersAlcohol exposureMedial prefrontal cortexVentral hippocampusProjection neuronsShort-term alcohol exposureLong-Evans rat pupsPrefrontal cortexBrain growth spurtThalamic projection neuronsDevelopmental alcohol exposureAlcohol spectrum disordersThalamic nucleus reuniensExecutive functioningRE neuronsNeuron lossThird trimesterThalamic connectivityRat modelRat pupsHippocampal circuitryRodent modelsBinge drinkingNucleus reuniensNeuron numberExecutive functioning-specific behavioral impairments in a rat model of human third trimester binge drinking implicate prefrontal-thalamo-hippocampal circuitry in Fetal Alcohol Spectrum Disorders
Gursky ZH, Savage LM, Klintsova AY. Executive functioning-specific behavioral impairments in a rat model of human third trimester binge drinking implicate prefrontal-thalamo-hippocampal circuitry in Fetal Alcohol Spectrum Disorders. Behavioural Brain Research 2021, 405: 113208. PMID: 33640395, PMCID: PMC8005484, DOI: 10.1016/j.bbr.2021.113208.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBehavior, AnimalBinge DrinkingCentral Nervous System DepressantsCognitive DysfunctionDisease Models, AnimalEthanolExecutive FunctionFemaleFetal Alcohol Spectrum DisordersHypothalamusMaleNerve NetPrefrontal CortexPregnancyPregnancy Trimester, ThirdRatsRats, Long-EvansThalamusConceptsExecutive functioningFetal alcohol spectrum disordersNovel object recognitionPrenatal alcohol exposureBehavioral impairmentsSpectrum disorderAlcohol spectrum disordersPrefrontal cortexObject recognitionBehavioral flexibility tasksSpontaneous alternationPlus-maze taskMedial prefrontal cortexAlcohol exposureThalamic nucleus reuniensAlcohol-exposed ratsLong-Evans rat pupsFlexibility taskReversal learningDiscrimination learningSham intubationsBehavioral alterationsDevelopmental alcoholAssociative memoryMaze task
2020
Single-day Postnatal Alcohol Exposure Induces Apoptotic Cell Death and Causes long-term Neuron Loss in Rodent Thalamic Nucleus Reuniens
Gursky ZH, Spillman EC, Klintsova AY. Single-day Postnatal Alcohol Exposure Induces Apoptotic Cell Death and Causes long-term Neuron Loss in Rodent Thalamic Nucleus Reuniens. Neuroscience 2020, 435: 124-134. PMID: 32251710, PMCID: PMC7236664, DOI: 10.1016/j.neuroscience.2020.03.046.Peer-Reviewed Original ResearchConceptsFetal alcohol spectrum disordersAlcohol exposureThalamic nucleus reuniensCell lossAlcohol administrationFemale Long-Evans rat pupsNucleus reuniensApoptotic cell deathNon-neuronal cell numbersThird trimester alcohol exposureLong-Evans rat pupsCell deathPostnatal alcohol exposureAlcohol-exposed animalsFunction of hippocampusDevelopmental alcohol exposurePostnatal day 7Evans rat pupsEarly life stressAlcohol spectrum disordersCell numberCell type-dependent mannerNeuron lossRat pupsRodent models
2019
Nucleus reuniens of the midline thalamus of a rat is specifically damaged after early postnatal alcohol exposure
Gursky ZH, Savage LM, Klintsova AY. Nucleus reuniens of the midline thalamus of a rat is specifically damaged after early postnatal alcohol exposure. Neuroreport 2019, 30: 748-752. PMID: 31095109, PMCID: PMC6599629, DOI: 10.1097/wnr.0000000000001270.Peer-Reviewed Original ResearchConceptsNon-neuronal cell numbersFetal alcohol spectrum disordersPostnatal day 4Alcohol spectrum disordersNeuroanatomical alterationsAlcohol exposureMidline thalamusFemale Long-Evans rat pupsNucleus reuniensDay 4Early postnatal alcohol exposureLong-Evans rat pupsNeuron numberCircuit-level alterationsPostnatal alcohol exposureTotal neuron numberMidline thalamic nucleiEthanol-induced changesCell numberThalamic nucleus reuniensAdministration of liquidsVentral midline thalamusThalamic nucleiNeuronal markersRat pups