2019
Rat NaV1.7 loss-of-function genetic model: Deficient nociceptive and neuropathic pain behavior with retained olfactory function and intra-epidermal nerve fibers
Grubinska B, Chen L, Alsaloum M, Rampal N, Matson D, Yang C, Taborn K, Zhang M, Youngblood B, Liu D, Galbreath E, Allred S, Lepherd M, Ferrando R, Kornecook T, Lehto S, Waxman S, Moyer B, Dib-Hajj S, Gingras J. Rat NaV1.7 loss-of-function genetic model: Deficient nociceptive and neuropathic pain behavior with retained olfactory function and intra-epidermal nerve fibers. Molecular Pain 2019, 15: 1744806919881846. PMID: 31550995, PMCID: PMC6831982, DOI: 10.1177/1744806919881846.Peer-Reviewed Original ResearchConceptsOlfactory functionNav1.7 proteinPain behaviorPain responseRat modelSmall-diameter dorsal root ganglion neuronsNormal intraepidermal nerve fibre densityIntraepidermal nerve fiber densityIntra-epidermal nerve fibersDorsal root ganglion neuronsNeuropathic pain behaviorsNeuropathic pain responsesSpinal nerve ligationNerve fiber densityDorsal root gangliaAction potential firingPeripheral nervous systemEarly postnatal developmentGenetic animal modelsNav1.7 lossNerve ligationPain targetsNeuropathic conditionsGanglion neuronsRoot ganglia
2012
Gain-of-function Nav1.8 mutations in painful neuropathy
Faber CG, Lauria G, Merkies IS, Cheng X, Han C, Ahn HS, Persson AK, Hoeijmakers JG, Gerrits MM, Pierro T, Lombardi R, Kapetis D, Dib-Hajj SD, Waxman SG. Gain-of-function Nav1.8 mutations in painful neuropathy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 19444-19449. PMID: 23115331, PMCID: PMC3511073, DOI: 10.1073/pnas.1216080109.Peer-Reviewed Original ResearchConceptsPainful peripheral neuropathySmall fiber neuropathyPainful neuropathyPeripheral neuropathyPainful small fiber neuropathyDorsal root ganglion neuronsSodium channelsApparent underlying causePeripheral nerve axonsDRG neuronsGanglion neuronsNeuropathyNerve axonsUnderlying causeFunction variantsCurrent clampPatientsPotential pathogenicityNeuronsMutationsHyperexcitabilityAxonsResponse
2002
Nitric Oxide Blocks Fast, Slow, and Persistent Na+ Channels in C-Type DRG Neurons by S-Nitrosylation
Renganathan M, Cummins T, Waxman S. Nitric Oxide Blocks Fast, Slow, and Persistent Na+ Channels in C-Type DRG Neurons by S-Nitrosylation. Journal Of Neurophysiology 2002, 87: 761-775. PMID: 11826045, DOI: 10.1152/jn.00369.2001.Peer-Reviewed Original ResearchConceptsSteady-state voltage-dependent inactivationDorsal root ganglion neuronsNitric oxide blockIncubation of neuronsNO scavenger hemoglobinSlow sodium channel inactivationNitric oxide donorFast TTXMembrane-permeable analogSlow TTXVoltage-dependent inactivationDRG neuronsGanglion neuronsSodium channel inactivationCurrent inhibitionOxide donorScavenger hemoglobinPersistent TTXPAPA-NONOateS-nitrosoTTXNeuronsChannel inactivationSlow inactivationCGMP-dependent protein kinase
2000
Localization of the tetrodotoxin-resistant sodium channel NaN in nociceptors
Fjell J, Hjelmström P, Hormuzdiar W, Milenkovic M, Aglieco F, Tyrrell L, Dib-Hajj S, Waxman S, Black J. Localization of the tetrodotoxin-resistant sodium channel NaN in nociceptors. Neuroreport 2000, 11: 199-202. PMID: 10683857, DOI: 10.1097/00001756-200001170-00039.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAxonsCorneaFemaleGanglia, SpinalImage Processing, Computer-AssistedImmunohistochemistryMolecular Sequence DataMyelin SheathNAV1.9 Voltage-Gated Sodium ChannelNerve FibersNeurons, AfferentNeuropeptidesNociceptorsPresynaptic TerminalsRanvier's NodesRatsRats, Sprague-DawleySciatic NerveSodium ChannelsTetrodotoxinConceptsSciatic nerveSmall diameter primary sensory neuronsSodium currentTetrodotoxin-resistant sodium channelsTetrodotoxin-resistant sodium currentDorsal root ganglion neuronsSodium channelsPrimary sensory neuronsAxonal sodium currentsNodes of RanvierNociceptive transmissionChannel immunoreactivityGanglion neuronsUnmyelinated fibersAxon terminalsSensory neuronsNerveImmunoreactivityAxonsNeuronsSpecific peptidesNociceptorsIB4CorneaAntibodies
1998
SNS Na+ channel expression increases in dorsal root ganglion neurons in the carrageenan inflammatory pain model
Tanaka M, Cummins T, Ishikawa K, Dib-Hajj S, Black J, Waxman S. SNS Na+ channel expression increases in dorsal root ganglion neurons in the carrageenan inflammatory pain model. Neuroreport 1998, 9: 967-972. PMID: 9601651, DOI: 10.1097/00001756-199804200-00003.Peer-Reviewed Original ResearchConceptsSmall DRG neuronsDorsal root ganglion neuronsInjection of carrageenanDRG neuronsInflamed limbGanglion neuronsSodium currentTTX-R sodium currentsTetrodotoxin-resistant sodium currentInflammatory pain modelDevelopment of hyperexcitabilitySodium channel expressionPatch-clamp recordingsInflammatory painPain modelChronic painCarrageenan injectionNociceptive cellsContralateral sideNaive ratsChannel expressionProjection fieldsMRNA expressionNeuronsSodium channels
1997
Axon-glia interactions: Building a smart nerve fiber
Waxman S. Axon-glia interactions: Building a smart nerve fiber. Current Biology 1997, 7: r406-r410. PMID: 9210363, DOI: 10.1016/s0960-9822(06)00203-x.Peer-Reviewed Original Research
1994
Activity‐dependent modulation of excitability: Implications for axonal physiology and pathophysiology
Stys P, Waxman S. Activity‐dependent modulation of excitability: Implications for axonal physiology and pathophysiology. Muscle & Nerve 1994, 17: 969-974. PMID: 7520532, DOI: 10.1002/mus.880170902.Peer-Reviewed Original Research
1991
Differential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons
Utzschneider D, Kocsis J, Waxman S. Differential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons. Brain Research 1991, 551: 136-141. PMID: 1913145, DOI: 10.1016/0006-8993(91)90924-k.Peer-Reviewed Original ResearchConceptsDorsal columnsDorsal rootsAfferent fibersCentral nervous system componentsPrimary afferent fibersSucrose gap chamberAction potential amplitudePrimary afferent axonsCompound action potentialDorsal spinal rootsNervous system componentsAxonal trunksPeripheral nervesSpinal cordSpinal rootsAfferent axonsCNS portionSchwann cellsAdult ratsPotential amplitudeAxon branchesAction potentialsHypoxiaMembrane potential changesMembrane depolarization
1988
Evidence for the presence of two types of potassium channels in the rat optic nerve
Gordon T, Kocsis J, Waxman S. Evidence for the presence of two types of potassium channels in the rat optic nerve. Brain Research 1988, 447: 1-9. PMID: 2454699, DOI: 10.1016/0006-8993(88)90959-6.Peer-Reviewed Original ResearchConceptsRat optic nervePostspike positivityOptic nerveAction potential waveformPotassium channelsAction potential broadeningSingle-fiber recordingsRepetitive firing patternsAction potential repolarizationTEA-sensitive channelsDistinct potassium channelsPotential waveformPronounced afterhyperpolarizationFiber recordingsWhole nerveIntracellular hyperpolarizationGap recordingsRepetitive firingMyelinated axonsNerveAction potentialsPotential repolarizationAfterhyperpolarizationFiring patternsProlonged depolarization
1986
Different effects of 4-aminopyridine on sensory and motor fibers: pathogenesis of paresthesias.
Kocsis J, Bowe C, Waxman S. Different effects of 4-aminopyridine on sensory and motor fibers: pathogenesis of paresthesias. Neurology 1986, 36: 117-20. PMID: 3001584, DOI: 10.1212/wnl.36.1.117.Peer-Reviewed Original Research
1983
The supernormal period of the cerebellar parallel fibers effects of [Ca2+]o and [K+]o
Malenka R, Kocsis J, Waxman S. The supernormal period of the cerebellar parallel fibers effects of [Ca2+]o and [K+]o. Pflügers Archiv - European Journal Of Physiology 1983, 397: 176-183. PMID: 6878005, DOI: 10.1007/bf00584354.Peer-Reviewed Original ResearchConceptsSupernormal periodConditioning stimulationActivity-dependent changesParallel fibersCerebellar parallel fibersConditioning volleyIon-sensitive microelectrodesConditioning stimulusExtracellular calciumLatency changesLatency shiftCortex exhibitExtracellular ionic concentrationsTest response latenciesTest latencyStimulationResponse latencyRelative increaseSmall increaseLatencyPeriodSuperfusateExcitabilityFreeze-fracture ultrastructure of developing and adult non-myelinated ganglion cell axolemma in the retinal nerve fibre layer
Black J, Foster R, Waxman S. Freeze-fracture ultrastructure of developing and adult non-myelinated ganglion cell axolemma in the retinal nerve fibre layer. Brain Cell Biology 1983, 12: 201-212. PMID: 6842274, DOI: 10.1007/bf01148462.Peer-Reviewed Original ResearchConceptsRetinal nerve fiber layerNerve fiber layerNon-myelinated axonsFiber layerParticle densityMean particle diameterParticle diameterLayerNeonatal ratsElectron microscopyAdult ratsDistal segmentsParticlesConduction propertiesAdult fibersAdult animalsΜm2AxonsLow densityDensityDevelopmental ageFibersRatsHigh densityRegeneration of spinal neurons in inframammalian vertebrates: morphological and developmental aspects.
Anderson M, Waxman S. Regeneration of spinal neurons in inframammalian vertebrates: morphological and developmental aspects. Journal Für Hirnforschung 1983, 24: 371-98. PMID: 6643991.Peer-Reviewed Original ResearchConceptsSpinal cordNerve cell bodiesSpinal neuronsCell bodiesNerve fibersAxon reactionElectromotor neuronsInframammalian vertebratesSpinal electromotor neuronsPeripheral nerve bridgesMammalian spinal cordCell deathNerve bridgeNew neuronsEpendymal cellsTrophic effectsCordNerve growthNeuronsNerve outgrowthCertain hormonesGrowth factorSternarchusExternal laminaAxon outgrowthEffects of extracellular potassium concentration on the excitability of the parallel fibres of the rat cerebellum.
Kocsis J, Malenka R, Waxman S. Effects of extracellular potassium concentration on the excitability of the parallel fibres of the rat cerebellum. The Journal Of Physiology 1983, 334: 225-244. PMID: 6864558, PMCID: PMC1197311, DOI: 10.1113/jphysiol.1983.sp014491.Peer-Reviewed Original Research
1982
Spatial heterogeneity of the axolemma of non-myelinated fibers in the optic disc of the adult rat
Black J, Waxman S, Foster R. Spatial heterogeneity of the axolemma of non-myelinated fibers in the optic disc of the adult rat. Cell And Tissue Research 1982, 224: 239-246. PMID: 7105135, DOI: 10.1007/bf00216871.Peer-Reviewed Original Research
1981
Impulse entrainment: Computer simulations and studies on the parallel fibers of the cerebellum
Kocsis J, Cummins K, Waxman S, Malenka R. Impulse entrainment: Computer simulations and studies on the parallel fibers of the cerebellum. Experimental Neurology 1981, 72: 628-637. PMID: 7238712, DOI: 10.1016/0014-4886(81)90011-x.Peer-Reviewed Original ResearchEnhanced parallel fiber frequency-following after reduction of postsynaptic activity
Kocsis J, Malenka R, Waxman S. Enhanced parallel fiber frequency-following after reduction of postsynaptic activity. Brain Research 1981, 207: 321-331. PMID: 6258738, DOI: 10.1016/0006-8993(81)90367-x.Peer-Reviewed Original ResearchConceptsCalcium antagonistsSynaptic activityPostsynaptic activityParallel fibersRat cerebellar cortexParallel fiber volleyFiber volleyNeuronal elementsPresynaptic elementsSynaptic potentialsCerebellar cortexLocal superfusionStimulation trainsSlow potentialsEnhancing effectAntagonistExtracellular pathwaysSuperfusionVolleysActivityCortexCerebellumAction potential electrogenesis in mammalian central axons.
Kocsis J, Waxman S. Action potential electrogenesis in mammalian central axons. Advances In Neurology 1981, 31: 299-312. PMID: 6275668.Peer-Reviewed Original ResearchPopulation response characteristics of fiber tracts in central white matter.
Kocsis J, Malenka R, Connors B, Waxman S, Cummins K. Population response characteristics of fiber tracts in central white matter. Progress In Clinical And Biological Research 1981, 52: 17-32. PMID: 7232442.Peer-Reviewed Original Research
1980
Effects of 4-aminopyridine on the frequency following properties of the parallel fibers of the cerebellar cortex
Kocsis J, Malenka R, Waxman S. Effects of 4-aminopyridine on the frequency following properties of the parallel fibers of the cerebellar cortex. Brain Research 1980, 195: 511-516. PMID: 6249447, DOI: 10.1016/0006-8993(80)90090-6.Peer-Reviewed Original Research