1988
Evidence for the presence of two types of potassium channels in the rat optic nerve
Gordon T, Kocsis J, Waxman S. Evidence for the presence of two types of potassium channels in the rat optic nerve. Brain Research 1988, 447: 1-9. PMID: 2454699, DOI: 10.1016/0006-8993(88)90959-6.Peer-Reviewed Original ResearchConceptsRat optic nervePostspike positivityOptic nerveAction potential waveformPotassium channelsAction potential broadeningSingle-fiber recordingsRepetitive firing patternsAction potential repolarizationTEA-sensitive channelsDistinct potassium channelsPotential waveformPronounced afterhyperpolarizationFiber recordingsWhole nerveIntracellular hyperpolarizationGap recordingsRepetitive firingMyelinated axonsNerveAction potentialsPotential repolarizationAfterhyperpolarizationFiring patternsProlonged depolarization
1987
Physiological effects of 4‐aminopyridine on demyelinated mammalian motor and sensory fibers
Bowe C, Kocsis J, Targ E, Waxman S. Physiological effects of 4‐aminopyridine on demyelinated mammalian motor and sensory fibers. Annals Of Neurology 1987, 22: 264-268. PMID: 2821876, DOI: 10.1002/ana.410220212.Peer-Reviewed Original ResearchConceptsSensory fibersClinical trialsAction potentialsPotassium channel blockadeDorsal root axonsCompound action potentialDorsal spinal rootsSingle action potentialMammalian motorIntrathecal injectionMultiple sclerosisSensory dysfunctionVentral rootsSpinal rootsNeuromuscular disordersSpecific fiber typesElectrophysiological responsesSingle stimulusPhysiological effectsTrialsFiber typesResponseParesthesiaSclerosisDysfunction
1986
Mammalian optic nerve fibers display two pharmacologically distinct potassium channels
Kocsis J, Gordon T, Waxman S. Mammalian optic nerve fibers display two pharmacologically distinct potassium channels. Brain Research 1986, 383: 357-361. PMID: 2429732, DOI: 10.1016/0006-8993(86)90040-5.Peer-Reviewed Original ResearchConceptsOptic nerve fibersNerve fibersDistinct potassium channelsPotassium channelsRat optic nerve fibersNerve action potentialsAction potential characteristicsAction potential repolarizationTEA-sensitive channelsIntracellular hyperpolarizationAction potentialsPotential repolarizationSuction electrodeTetraethylammoniumPotential characteristicsRepolarizationPositivityDifferent effects of 4-aminopyridine on sensory and motor fibers: pathogenesis of paresthesias.
Kocsis J, Bowe C, Waxman S. Different effects of 4-aminopyridine on sensory and motor fibers: pathogenesis of paresthesias. Neurology 1986, 36: 117-20. PMID: 3001584, DOI: 10.1212/wnl.36.1.117.Peer-Reviewed Original Research
1985
Myelin sheath remodelling in regenerated rat sciatic nerve
Hildebrand C, Kocsis J, Berglund S, Waxman S. Myelin sheath remodelling in regenerated rat sciatic nerve. Brain Research 1985, 358: 163-170. PMID: 2416385, DOI: 10.1016/0006-8993(85)90960-6.Peer-Reviewed Original ResearchConceptsRat sciatic nerveSciatic nerveRegenerated nervesAdult rat sciatic nerveRegenerated rat sciatic nerveNormal control nervesLight microscopic examinationAction potential waveformCrush lesionMonths survivalNerve segmentsControl nervesSame nerveIndividual nervesNerve fibersNerveShort sheathMyelin layersMyelin sheathPotassium channelsMicroscopic examinationLigature‐induced injury in peripheral nerve: Electrophysiological observations on changes in action potential characteristics following blockade of potassium conductance
Waxman S, Kocsis J, Eng D. Ligature‐induced injury in peripheral nerve: Electrophysiological observations on changes in action potential characteristics following blockade of potassium conductance. Muscle & Nerve 1985, 8: 85-92. PMID: 2414652, DOI: 10.1002/mus.880080202.Peer-Reviewed Original ResearchConceptsAction potentialsRepetitive firingSingle stimulusPotassium channelsCompound action potentialRat sciatic nerveAction potential propertiesWhole-nerve responseAction potential characteristicsIntra-axonal recordingsAction potential waveformNerve segmentsSciatic nerveNerve responsesPeripheral nervesInjury siteMyelinated fibersLater spikesElectrophysiological observationsNerveRefractory periodFiring patternsPotassium conductancePotential waveformInitial spike
1983
Maturation of mammalian myelinated fibers: changes in action-potential characteristics following 4-aminopyridine application
Kocsis J, Ruiz J, Waxman S. Maturation of mammalian myelinated fibers: changes in action-potential characteristics following 4-aminopyridine application. Journal Of Neurophysiology 1983, 50: 449-463. PMID: 6310062, DOI: 10.1152/jn.1983.50.2.449.Peer-Reviewed Original ResearchLong-term regenerated nerve fibres retain sensitivity to potassium channel blocking agents
Kocsis J, Waxman S. Long-term regenerated nerve fibres retain sensitivity to potassium channel blocking agents. Nature 1983, 304: 640-642. PMID: 6308475, DOI: 10.1038/304640a0.Peer-Reviewed Original ResearchConceptsNerve fibersPotassium channelsMyelinated peripheral nerve fibresAxon segmentsPeripheral nerve fibersAxon sproutsEndoneurial tubesNerve crushFunctional recoveryFunctional organizationMyelinated fibersAxon cylindersSchwann cellsBurst activityMyelinated axonsMammalian axonsAxonsPeripheral connectionsMembrane depolarizationBasement membraneK channelsRegenerated fibersAxon maturationEffects of 4-aminopyridine on rapidly and slowly conducting axons of rat corpus callosum
Preston R, Waxman S, Kocsis J. Effects of 4-aminopyridine on rapidly and slowly conducting axons of rat corpus callosum. Experimental Neurology 1983, 79: 808-820. PMID: 6825765, DOI: 10.1016/0014-4886(83)90044-4.Peer-Reviewed Original ResearchConceptsRat corpus callosumCallosal fibersCerebral axonsNerve fibersCorpus callosumMammalian peripheral nerve fibersNegative waveVoltage-dependent potassium currentsSecond negative waveNon-myelinated nerve fibresPeripheral nerve fibersField potentialsShort-latency wavesFirst negative waveCallosal stimulationPotassium blockersPotassium currentAction potentialsPeripheral fibersCallosumRecording electrodesMembrane repolarizationAxonsFunctional organizationComparable differences
1982
Regenerating mammalian nerve fibres: changes in action potential waveform and firing characteristics following blockage of potassium conductance
Kocsis J, Waxman S, Hildebrand C, Ruiz J. Regenerating mammalian nerve fibres: changes in action potential waveform and firing characteristics following blockage of potassium conductance. Proceedings Of The Royal Society B 1982, 217: 77-87. PMID: 6131423, DOI: 10.1098/rspb.1982.0095.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAminopyridinesAnimalsAxonsIon ChannelsMaleNerve RegenerationNeural ConductionPotassiumRatsConceptsRegenerating axonsNerve fibersFiring propertiesAction potentialsPotassium conductancePotassium channelsCompound action potentialSciatic nerve fibersEarly regenerating axonsAction potential waveformRat nerve fibresMammalian nerve fibresDemyelinated axonsMyelinated fibersExtracellular applicationAxonsRecording techniquesSingle stimulusFiring characteristicsPotential waveformPresent studyMembranes, Myelin, and the Pathophysiology of Multiple Sclerosis
Waxman S. Membranes, Myelin, and the Pathophysiology of Multiple Sclerosis. New England Journal Of Medicine 1982, 306: 1529-1533. PMID: 7043271, DOI: 10.1056/nejm198206243062505.Peer-Reviewed Original Research
1981
Enhanced parallel fiber frequency-following after reduction of postsynaptic activity
Kocsis J, Malenka R, Waxman S. Enhanced parallel fiber frequency-following after reduction of postsynaptic activity. Brain Research 1981, 207: 321-331. PMID: 6258738, DOI: 10.1016/0006-8993(81)90367-x.Peer-Reviewed Original ResearchConceptsCalcium antagonistsSynaptic activityPostsynaptic activityParallel fibersRat cerebellar cortexParallel fiber volleyFiber volleyNeuronal elementsPresynaptic elementsSynaptic potentialsCerebellar cortexLocal superfusionStimulation trainsSlow potentialsEnhancing effectAntagonistExtracellular pathwaysSuperfusionVolleysActivityCortexCerebellumAction potential electrogenesis in mammalian central axons.
Kocsis J, Waxman S. Action potential electrogenesis in mammalian central axons. Advances In Neurology 1981, 31: 299-312. PMID: 6275668.Peer-Reviewed Original Research
1980
Absence of potassium conductance in central myelinated axons
Kocsis J, Waxman S. Absence of potassium conductance in central myelinated axons. Nature 1980, 287: 348-349. PMID: 7421994, DOI: 10.1038/287348a0.Peer-Reviewed Original ResearchConceptsCentral myelinated axonsMyelinated axonsAction potentialsPotassium conductanceDorsal column axonsVoltage-clamp experimentsLate outward currentOutward currentsAxonsSodium ion permeabilityLate increaseDepolarization phasePotassium permeabilityAxonal membraneRepolarizationMyelinInitial increaseVoltage-dependent changesSodium inactivationDemyelinationPrevious studiesEffects of 4-aminopyridine on the frequency following properties of the parallel fibers of the cerebellar cortex
Kocsis J, Malenka R, Waxman S. Effects of 4-aminopyridine on the frequency following properties of the parallel fibers of the cerebellar cortex. Brain Research 1980, 195: 511-516. PMID: 6249447, DOI: 10.1016/0006-8993(80)90090-6.Peer-Reviewed Original Research