1993
Molecular dissection of the myelinated axon
Waxman S, Ritchie J. Molecular dissection of the myelinated axon. Annals Of Neurology 1993, 33: 121-136. PMID: 7679565, DOI: 10.1002/ana.410330202.Peer-Reviewed Original ResearchConceptsMyelinated axonsInternodal axon membraneDemyelinated axonsCentral nervous system white matterNervous system white matterRestoration of conductionImportant therapeutic approachSchwann cell processesWhite matter axonsInflux of Ca2Important pathophysiological implicationsGlial cell processesAction potential conductionAxonal excitabilityGlial cellsAnoxic injuryMyelinated fibersTherapeutic approachesAstrocyte processesCell processesPathophysiological implicationsRepetitive firingWhite matterNeurological disordersAction potentials
1992
Effects of Temperature on Evoked Electrical Activity and Anoxic Injury in CNS White Matter
Stys P, Waxman S, Ransom B. Effects of Temperature on Evoked Electrical Activity and Anoxic Injury in CNS White Matter. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 977-986. PMID: 1400652, DOI: 10.1038/jcbfm.1992.135.Peer-Reviewed Original ResearchConceptsFunctional recoveryWhite matterAnoxic injuryMin of anoxiaOptic nerveFunctional outcomeTypical CNS white matter tractAnoxic exposureIntracellular Ca2Anoxic/ischemic injuryCNS white matter tractCompound action potential areaGray matterIsolated rat optic nerveGreater functional recoveryEvoked electrical activityAction potential areaCNS white matterRat optic nerveWhite matter tractsFunctional injuryIschemic injuryPathological increaseAnoxic damageCAP peakIonic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger
Stys P, Waxman S, Ransom B. Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger. Journal Of Neuroscience 1992, 12: 430-439. PMID: 1311030, PMCID: PMC6575619, DOI: 10.1523/jneurosci.12-02-00430.1992.Peer-Reviewed Original ResearchConceptsRat optic nerveCompound action potentialAnoxic injuryOptic nerveWhite matterAction potentialsCentral white matter tractsWhite matter injuryCNS white matterMembrane depolarizationAnoxia/ischemiaWhite matter tractsCNS protectionAnoxic insultMyelinated tractsChannel blockersExchanger blockerIrreversible injuryExtracellular Ca2Mammalian CNSNerveInjuryMore injuriesBlockersFunctional integrity
1991
Reverse Operation of the Na+ ‐Ca2+ Exchanger Mediates Ca 2+ Influx during Anoxia in Mammalian CNS White Mattera
STYS P, WAXMAN S, RANSOM B. Reverse Operation of the Na+ ‐Ca2+ Exchanger Mediates Ca 2+ Influx during Anoxia in Mammalian CNS White Mattera. Annals Of The New York Academy Of Sciences 1991, 639: 328-332. PMID: 1785859, DOI: 10.1111/j.1749-6632.1991.tb17321.x.Peer-Reviewed Original ResearchNa+‐Ca2+ exchanger mediates Ca2+ influx during anoxia in mammalian central nervous system white matter
Stys P, Waxman S, Ransom B. Na+‐Ca2+ exchanger mediates Ca2+ influx during anoxia in mammalian central nervous system white matter. Annals Of Neurology 1991, 30: 375-380. PMID: 1952825, DOI: 10.1002/ana.410300309.Peer-Reviewed Original ResearchMeSH KeywordsAmilorideAnimalsBrainCalciumCarrier ProteinsIn Vitro TechniquesOptic NerveOxygenRatsSodium-Calcium ExchangerTetrodotoxinConceptsWhite matterIsolated rat optic nerveCentral nervous system white matterNervous system white matterWhite matter injuryRat optic nerveMammalian central nervous systemSevere neurological impairmentCompound action potentialType of injuryCentral nervous systemFunctional recoveryOptic nervePharmacological blockadeNeurological impairmentAnoxic injuryIrreversible injuryNervous systemAction potentialsInjuryInfluxCa2Critical mechanismCellsNerve
1977
The clinical and physiological implications of hepatoma B12-binding proteins.
Waxman S, Liu C, Schreiber C, Helson L. The clinical and physiological implications of hepatoma B12-binding proteins. Cancer Research 1977, 37: 1908-14. PMID: 66988.Peer-Reviewed Original ResearchConceptsCell linesElevated sialyltransferase activityB12 binding capacitySerum B12Hepatocellular carcinomaHepatoma seraSialic acid contentNormal liverHepatoma cell lineB12Previous casesPatientsHepatomaPerfusateSialyltransferase activityLiverSerumPhysiological implicationsChemotherapyCarcinomaNeoplasiaProteinTumorsDisease
1975
Isolation and characterization of a novel vitamin B12-binding protein associated with hepatocellular carcinoma.
Burger R, Waxman S, Gilbert H, Mehlman C, Allen R. Isolation and characterization of a novel vitamin B12-binding protein associated with hepatocellular carcinoma. Journal Of Clinical Investigation 1975, 56: 1262-1270. PMID: 171283, PMCID: PMC301989, DOI: 10.1172/jci108202.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, HepatocellularCarrier ProteinsFemaleHumansLiverLiver NeoplasmsNeoplasm ProteinsVitamin B 12ConceptsVitamin B12-binding proteinsHepatocellular carcinomaR-type proteinNormal liver tissueCertain patientsAdolescent patientsPleural fluidHuman milkSame patientPatientsSialic acid contentTumor tissueImmunologic propertiesLiver tissueSurvival studiesMore sialic acidCarcinomaPlasma survivalHigh levelsSialic acidImmunoprecipitation assaysTissueSodium dodecyl sulfate-polyacrylamide gel electrophoresisDodecyl sulfate-polyacrylamide gel electrophoresisApparent molecular weight