2005
Characterizing the Mechanisms of Progression in Multiple Sclerosis: Evidence and New Hypotheses for Future Directions
Frohman E, Filippi M, Stuve O, Waxman S, Corboy J, Phillips J, Lucchinetti C, Wilken J, Karandikar N, Hemmer B, Monson N, De Keyser J, Hartung H, Steinman L, Oksenberg J, Cree B, Hauser S, Racke M. Characterizing the Mechanisms of Progression in Multiple Sclerosis: Evidence and New Hypotheses for Future Directions. JAMA Neurology 2005, 62: 1345-1356. PMID: 16157741, DOI: 10.1001/archneur.62.9.1345.Peer-Reviewed Original ResearchConceptsMultiple sclerosisProgression of MSCause of progressionMechanisms of progressionMS exacerbationDisease courseInflammatory cascadeClinical manifestationsTherapeutic strategiesDisease processTreatment interventionsEvidence-based observationsEmergence of disabilityProgressionDiseasePotential mechanismsTreatment effectsSclerosisProgressive stagesNovel research initiativesExacerbationTherapyIllnessMajor advancementsExpert perspectives
1976
Probability of conduction deficit as related to fiber length in random-distribution models of peripheral neuropathies
Waxman S, Brill M, Geschwind N, Sabin T, Lettvin J. Probability of conduction deficit as related to fiber length in random-distribution models of peripheral neuropathies. Journal Of The Neurological Sciences 1976, 29: 39-53. PMID: 181541, DOI: 10.1016/0022-510x(76)90079-4.Peer-Reviewed Original ResearchConceptsPeripheral neuropathyAxonal dysfunctionSensory deficitsDistal sensory deficitsNormal sensory conductionRapid clinical progressionConduction deficitsSensory conductionClinical progressionNerve fibersConduction blockNeuropathyDysfunctionMarked reductionProximodistal gradientPossible correlatesDeficitsSmall increaseParesthesiaeAbnormalitiesProgression