2016
Pharmacotherapy for Pain in a Family With Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling
Geha P, Yang Y, Estacion M, Schulman BR, Tokuno H, Apkarian AV, Dib-Hajj SD, Waxman SG. Pharmacotherapy for Pain in a Family With Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling. JAMA Neurology 2016, 73: 659. PMID: 27088781, DOI: 10.1001/jamaneurol.2016.0389.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAdultAnalgesics, Non-NarcoticBrainCarbamazepineChronic PainDNA Mutational AnalysisDouble-Blind MethodElectric StimulationErythromelalgiaFemaleGanglia, SpinalHumansMagnetic Resonance ImagingMaleMutationNAV1.7 Voltage-Gated Sodium ChannelPain MeasurementRegression AnalysisSensory Receptor CellsConceptsMean episode durationDRG neuronsPatient 1Nav1.7 mutationEpisode durationDorsal root ganglion neuronsPlacebo-controlled studyMaintenance periodAttenuation of painEffects of carbamazepineBrain activityFunctional magnetic resonance imagingMagnetic resonance imagingT mutationMutant channelsFunctional magnetic resonanceNeuropathic painSecondary somatosensoryChronic painPain areaPatient 2Ganglion neuronsEffective pharmacotherapyNight awakeningsPlacebo
2009
Multiple Sclerosis
Preiningerova J, Bomprezzi R, Vollmer T, Waxman S. Multiple Sclerosis. 2009 DOI: 10.1002/9780470015902.a0000192.pub2.Peer-Reviewed Original ResearchCentral nervous systemMagnetic resonance imagingMultiple sclerosisImmune attackMS patientsNeurological disabilityInflammatory diseasesT cellsNervous systemTreatment of MSPathogenesis of MSProgression of MSBrain magnetic resonance imagingYoung womenAutoaggressive T cellsRegulatory T cellsLong-term disabilityDiseases of myelinMajor advancesDisease activityOngoing inflammationImmunotherapeutic strategiesAutoimmune diseasesClinical appearanceHumoral mechanisms
1993
Painless aortic dissection presenting as a progressive myelopathy
Holloway S, Fayad P, Kalb R, Guarnaccia J, Waxman S. Painless aortic dissection presenting as a progressive myelopathy. Journal Of The Neurological Sciences 1993, 120: 141-144. PMID: 8138802, DOI: 10.1016/0022-510x(93)90265-z.Peer-Reviewed Original ResearchConceptsPainless aortic dissectionAortic dissectionProgressive myelopathyCentral nervous system ischemiaSpinal cord syndromeThoracic aortic dissectionAbsence of painThoracic vertebral bodyMagnetic resonance imagingTransverse myelopathyCord syndromeNeurologic deficitsNeurologic symptomsIschemic changesEarly recognitionSpinal cordDifferential diagnosisNew therapiesVertebral bodyResonance imagingMyelopathyThoracic vertebraeDissectionPainIschemia