2023
9. THE GENETIC ARCHITECTURE OF PAIN INTENSITY IN THE MILLION VETERAN PROGRAM
Toikumo S, Vickers-Smith R, Jinwala Z, Xu H, Saini D, Hartwell E, Pavicic M, Sullivan K, Jacobson D, Cheatle M, Zhou H, Waxman S, Justice A, Kember R, Kranzler H. 9. THE GENETIC ARCHITECTURE OF PAIN INTENSITY IN THE MILLION VETERAN PROGRAM. European Neuropsychopharmacology 2023, 75: s60-s61. DOI: 10.1016/j.euroneuro.2023.08.120.Peer-Reviewed Original ResearchIndependent lociGenetic architectureMillion Veteran ProgramGenome-wide association testingIndependent genetic lociLinkage disequilibrium score regressionDrug-gene interaction databaseDisequilibrium score regressionNovel genetic variantsPotential drug targetsComplex traitsGWAS resultsCausal genesDruggable genomeDrug repurposing analysisGenetic lociDruggable genesInteraction databasesDrug targetsGenetic correlationsMolecular contributorsAssociation testingLociPsychiatric traitsScore regression
2017
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview
Alexander S, Kelly E, Marrion N, Peters J, Faccenda E, Harding S, Pawson A, Sharman J, Southan C, Buneman O, Cidlowski J, Christopoulos A, Davenport A, Fabbro D, Spedding M, Striessnig J, Davies J, Collaborators C, Abbracchio M, Aldrich R, Al‐Hosaini K, Arumugam T, Attali B, Bäck M, Barnes N, Bathgate R, Beart P, Becirovic E, Bettler B, Biel M, Birdsall N, Blaho V, Boison D, Bräuner‐osborne H, Bröer S, Bryant C, Burnstock G, Calo G, Catterall W, Ceruti S, Chan S, Chandy K, Chazot P, Chiang N, Chun J, Chung J, Clapham D, Clapp L, Connor M, Cox H, Davies P, Dawson P, Decaen P, Dent G, Doherty P, Douglas S, Dubocovich M, Fong T, Fowler C, Frantz A, Fuller P, Fumagalli M, Futerman A, Gainetdinov R, Gershengorn M, Goldin A, Goldstein S, Goudet C, Gregory K, Grissmer S, Gundlach A, Hagenbuch B, Hamann J, Hammond, Hancox J, Hanson J, Hanukoglu I, Hay D, Hobbs A, Hollenberg A, Holliday N, Hoyer D, Ijzerman A, Inui K, Irving A, Ishii S, Jacobson K, Jan L, Jarvis M, Jensen R, Jockers R, Kaczmarek L, Kanai Y, Karnik S, Kellenberger S, Kemp S, Kennedy C, Kerr I, Kihara Y, Kukkonen J, Larhammar D, Leach K, Lecca D, Leeman S, Leprince J, Lolait S, Macewan D, Maguire J, Marshall F, Mazella J, Mcardle C, Michel M, Miller L, Mitolo V, Mizuno H, Monk P, Mouillac B, Murphy P, Nahon J, Nerbonne J, Nichols C, Norel X, Offermanns S, Palmer L, Panaro M, Papapetropoulos A, Perez‐reyes E, Pertwee R, Pintor S, Pisegna, Plant L, Poyner, Prossnitz E, Pyne S, Ramachandran R, Ren D, Rondard P, Ruzza C, Sackin H, Sanger G, Sanguinetti M, Schild L, Schiöth H, Schulte G, Schulz S, Segaloff D, Serhan C, Singh K, Slesinger P, Snutch T, Sobey C, Stewart G, Stoddart L, Summers R, Szabo C, Thwaites D, Toll L, Trimmer J, Tucker S, Vaudry H, Verri T, Vilargada J, Waldman, Ward D, Waxman S, Wei A, Willars G, Wong S, Woodruff T, Wulff H, Ye R, Yung Y, Zajac J. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview. British Journal Of Pharmacology 2017, 174: s1-s16. PMID: 29055037, PMCID: PMC5650665, DOI: 10.1111/bph.13882.Peer-Reviewed Original ResearchConceptsBest available pharmacological toolsOfficial IUPHAR classificationAvailable pharmacological toolsDrug targetsIon channelsG protein-coupled receptorsHuman drug targetsLigand-gated ion channelsProtein-coupled receptorsVoltage-gated ion channelsNomenclature guidanceClinical pharmacologyCatalytic receptorsSelective pharmacologyOpen access knowledgebaseNuclear hormone receptorsPharmacological toolsHormone receptorsPrevious GuidesReceptorsLandscape formatPharmacologyBiennial publicationConcise guideRelated targets
2015
The Concise Guide to PHARMACOLOGY 2015/16: Overview
Alexander S, Kelly E, Marrion N, Peters J, Benson H, Faccenda E, Pawson A, Sharman J, Southan C, Buneman O, Catterall W, Cidlowski J, Davenport A, Fabbro D, Fan G, McGrath J, Spedding M, Davies J, Collaborators C, Aldrich R, Attali B, Bäck M, Barnes N, Bathgate R, Beart P, Becirovic E, Biel M, Birdsall N, Boison D, Bräuner‐Osborne H, Bröer S, Bryant C, Burnstock G, Burris T, Cain D, Calo G, Chan S, Chandy K, Chiang N, Christakos S, Christopoulos A, Chun J, Chung J, Clapham D, Connor M, Coons L, Cox H, Dautzenberg F, Dent G, Douglas S, Dubocovich M, Edwards D, Farndale R, Fong T, Forrest D, Fowler C, Fuller P, Gainetdinov R, Gershengorn M, Goldin A, Goldstein S, Grimm S, Grissmer S, Gundlach A, Hagenbuch B, Hammond, Hancox J, Hartig S, Hauger R, Hay D, Hébert T, Hollenberg A, Holliday N, Hoyer D, Ijzerman A, Inui K, Ishii S, Jacobson K, Jan L, Jarvis G, Jensen R, Jetten A, Jockers R, Kaczmarek L, Kanai Y, Kang H, Karnik S, Kerr I, Korach K, Lange C, Larhammar D, Leeb‐Lundberg F, Leurs R, Lolait S, Macewan D, Maguire J, May J, Mazella J, Mcardle C, Mcdonnell D, Michel M, Miller L, Mitolo V, Monie T, Monk P, Mouillac B, Murphy P, Nahon J, Nerbonne J, Nichols C, Norel X, Oakley R, Offermanns S, Palmer L, Panaro M, Perez‐Reyes E, Pertwee R, Pike J, Pin J, Pintor S, Plant L, Poyner, Prossnitz E, Pyne S, Ren D, Richer J, Rondard P, Ross R, Sackin H, Safi R, Sanguinetti M, Sartorius C, Segaloff D, Sladek F, Stewart G, Stoddart L, Striessnig J, Summers R, Takeda Y, Tetel M, Toll L, Trimmer J, Tsai M, Tsai S, Tucker S, Usdin T, Vilargada J, Vore M, Ward D, Waxman S, Webb P, Wei A, Weigel N, Willars G, Winrow C, Wong S, Wulff H, Ye R, Young M, Zajac J. The Concise Guide to PHARMACOLOGY 2015/16: Overview. British Journal Of Pharmacology 2015, 172: 5729-5743. PMID: 26650438, PMCID: PMC4718217, DOI: 10.1111/bph.13347.Peer-Reviewed Original ResearchConceptsBest available pharmacological toolsOfficial IUPHAR classificationAvailable pharmacological toolsDrug targetsIon channelsG protein-coupled receptorsHuman drug targetsLigand-gated ion channelsProtein-coupled receptorsVoltage-gated ion channelsNomenclature guidanceIUPHAR-DBMajor pharmacological targetCatalytic receptorsOpen access knowledgebaseNuclear hormone receptorsPharmacological targetsPharmacological toolsHormone receptorsNC-IUPHARPrevious GuidesReceptorsLandscape formatConcise guideRelated targets
2005
Chapter 20 New Molecular Targets for the Treatment of Neuropathic Pain
Wood J, Waxman S. Chapter 20 New Molecular Targets for the Treatment of Neuropathic Pain. 2005, 339-355. DOI: 10.1016/b978-012738903-5/50021-7.Peer-Reviewed Original ResearchNeuropathic painPeripheral nervous system degenerationGene regulation studiesMolecular targetsAnimal modelsInteresting drug targetGene expressionRegulatory moleculesNew molecular targetsMolecular mechanismsEffective drug developmentNervous system degenerationTransgenic animalsUseful animal modelRegulation studiesDrug targetsGene ablationEfficacy of drugsConsequence of diseaseHerpes zosterImmunodeficiency syndromeRecent insightsPeripheral nervesSystem degenerationPain