2023
Voltage-gated sodium channels (Na<sub>V</sub>) in GtoPdb v.2023.1
Catterall W, Goldin A, Waxman S. Voltage-gated sodium channels (NaV) in GtoPdb v.2023.1. IUPHAR/BPS Guide To Pharmacology CITE 2023, 2023 DOI: 10.2218/gtopdb/f82/2023.1.Peer-Reviewed Original ResearchTransmembrane segmentsLarge extracellular N-terminal domainSingle transmembrane segmentPotassium channel structureShort cytoplasmic domainFourth transmembrane segmentN-terminal domainExtracellular N-terminal domainSodium channelsMost excitable cellsNC-IUPHAR SubcommitteeGlutamate side chainCytoplasmic domainFatty acyl chainsHomologous domainsNovel structural featuresVoltage-gated sodium channelsShort selectivity filterSodium-selective ion channelsΒ-subunitChannel gatingSelectivity filterIon channelsSubunitsPore region
2021
Voltage-gated sodium channels (Na<sub>V</sub>) in GtoPdb v.2021.3
Catterall W, Goldin A, Waxman S. Voltage-gated sodium channels (NaV) in GtoPdb v.2021.3. IUPHAR/BPS Guide To Pharmacology CITE 2021, 2021 DOI: 10.2218/gtopdb/f82/2021.3.Peer-Reviewed Original ResearchTransmembrane segmentsLarge extracellular N-terminal domainSingle transmembrane segmentPotassium channel structureShort cytoplasmic domainFourth transmembrane segmentN-terminal domainExtracellular N-terminal domainSodium channelsMost excitable cellsNC-IUPHAR SubcommitteeGlutamate side chainCytoplasmic domainFatty acyl chainsHomologous domainsNovel structural featuresVoltage-gated sodium channelsShort selectivity filterSodium-selective ion channelsΒ-subunitChannel gatingSelectivity filterIon channelsSubunitsPore region
2019
Voltage-gated sodium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Catterall W, Goldin A, Waxman S. Voltage-gated sodium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide To Pharmacology CITE 2019, 2019 DOI: 10.2218/gtopdb/f82/2019.4.Peer-Reviewed Original ResearchTransmembrane segmentsLarge extracellular N-terminal domainSingle transmembrane segmentPotassium channel structureShort cytoplasmic domainFourth transmembrane segmentN-terminal domainExtracellular N-terminal domainSodium channelsMost excitable cellsNC-IUPHAR SubcommitteeGlutamate side chainCytoplasmic domainFatty acyl chainsHomologous domainsNovel structural featuresShort selectivity filterVoltage-gated sodium channelsSodium-selective ion channelsΒ-subunitChannel gatingSelectivity filterIUPHAR/BPS GuideIon channelsSubunits
2009
The ataxia3 Mutation in the N-Terminal Cytoplasmic Domain of Sodium Channel Nav1.6 Disrupts Intracellular Trafficking
Sharkey LM, Cheng X, Drews V, Buchner DA, Jones JM, Justice MJ, Waxman SG, Dib-Hajj SD, Meisler MH. The ataxia3 Mutation in the N-Terminal Cytoplasmic Domain of Sodium Channel Nav1.6 Disrupts Intracellular Trafficking. Journal Of Neuroscience 2009, 29: 2733-2741. PMID: 19261867, PMCID: PMC2679640, DOI: 10.1523/jneurosci.6026-08.2009.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCell LineChromosome MappingCytoplasmData Interpretation, StatisticalDNA, ComplementaryElectrophysiologyEthylnitrosoureaImmunohistochemistryMachado-Joseph DiseaseMiceMice, Inbred C57BLMutagensMutationMutation, MissenseNAV1.6 Voltage-Gated Sodium ChannelNerve Tissue ProteinsPatch-Clamp TechniquesSciatic NerveSodium ChannelsSubcellular FractionsTransfectionConceptsMutant channelsCytoplasmic N-terminal regionN-terminal cytoplasmic domainCytoplasmic N-terminal domainMouse chromosome 15N-terminal domainN-terminal regionAmino acid substitution p.Primary cerebellar granule cellsVoltage-dependent inward sodium currentMutant proteinsCytoplasmic domainJuvenile lethalityCis-GolgiTrafficking defectsPlasma membraneSodium channelsIntracellular traffickingProtein abundanceWild typeN-terminusGolgi complexMutant transcriptsChromosome 15Whole-cell patch-clamp studies
2001
Fibroblast Growth Factor Homologous Factor 1B Binds to the C Terminus of the Tetrodotoxin-resistant Sodium Channel rNav1.9a (NaN)*
Liu C, Dib-Hajj S, Waxman S. Fibroblast Growth Factor Homologous Factor 1B Binds to the C Terminus of the Tetrodotoxin-resistant Sodium Channel rNav1.9a (NaN)*. Journal Of Biological Chemistry 2001, 276: 18925-18933. PMID: 11376006, DOI: 10.1074/jbc.m101606200.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAmino Acid SequenceAnimalsBlotting, WesternCell LineConserved SequenceCytoplasmDNA, ComplementaryDrug ResistanceFibroblast Growth FactorsGene LibraryGlutathione TransferaseGrowth SubstancesHumansMiceModels, BiologicalMolecular Sequence DataNAV1.9 Voltage-Gated Sodium ChannelNeuropeptidesPlasmidsProtein BindingProtein Structure, TertiaryRatsReverse Transcriptase Polymerase Chain ReactionRNASequence Analysis, DNASequence Homology, Amino AcidSodium ChannelsTetrodotoxinTissue DistributionTwo-Hybrid System TechniquesConceptsC-terminusTerminal polypeptideTwo-hybrid screenMammalian cell linesC-terminal regionN-terminal 5Fibroblast growth factor family membersFibroblast growth factor (FGF) familySodium channelsAmino acid residuesFactor family membersGrowth factor family membersCytoplasmic domainFirst growth factorGrowth factor familyFactor familyIntracellular segmentAcid residuesCell membraneFunctional significanceChannel complexDirect interactionCell linesTerminusPolypeptide