2023
Randomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer
Cartmel B, Li F, Zhou Y, Gottlieb L, Lu L, Mszar R, Harrigan M, Ligibel J, Gogoi R, Schwartz P, Risch H, Irwin M. Randomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer. Cancer Medicine 2023, 12: 15492-15503. PMID: 37269192, PMCID: PMC10417064, DOI: 10.1002/cam4.6187.Peer-Reviewed Original ResearchConceptsExercise interventionOvarian cancerTrial of exerciseExercise-induced changesMin/weekGroup differencesSubset of participantsCause mortalityExercise groupOverall survivalStudy armsCA 125Randomized trialsBlood biomarkersBlood drawBreast cancerClinical significanceIGF-1Effect model analysisSecondary analysisBeneficial effectsCancerBiomarkersTrialsWomen
2019
Moderators of Exercise Effects on Cancer-related Fatigue: A Meta-analysis of Individual Patient Data.
VAN Vulpen JK, Sweegers MG, Peeters PHM, Courneya KS, Newton RU, Aaronson NK, Jacobsen PB, Galvão DA, Chinapaw MJ, Steindorf K, Irwin ML, Stuiver MM, Hayes S, Griffith KA, Mesters I, Knoop H, Goedendorp MM, Mutrie N, Daley AJ, McConnachie A, Bohus M, Thorsen L, Schulz KH, Short CE, James EL, Plotnikoff RC, Schmidt ME, Ulrich CM, VAN Beurden M, Oldenburg HS, Sonke GS, VAN Harten WH, Schmitz KH, Winters-Stone KM, Velthuis MJ, Taaffe DR, VAN Mechelen W, Kersten MJ, Nollet F, Wenzel J, Wiskemann J, Verdonck-DE Leeuw IM, Brug J, May AM, Buffart LM. Moderators of Exercise Effects on Cancer-related Fatigue: A Meta-analysis of Individual Patient Data. Medicine & Science In Sports & Exercise 2019, 52: 303-314. PMID: 31524827, PMCID: PMC6962544, DOI: 10.1249/mss.0000000000002154.Peer-Reviewed Original ResearchConceptsIndividual patient dataCancer-related fatigueExercise interventionSignificant beneficial effectPatient dataClinical characteristicsSupervised interventionBeneficial effectsClustering of patientsExercise intervention effectsExercise RCTsBaseline fatigueExercise effectsGroup allocationClinical practiceMeta-AnalysisLinear mixed-effects modelsIntervention effectsPatientsMixed-effects modelsLonger durationInterventionRandom interceptDifferential effectsEvidence of moderation
2009
The Biological Mechanisms by Which Physical Activity Might Have an Impact on Outcome/Prognosis After a Breast Cancer Diagnosis
Irwin M. The Biological Mechanisms by Which Physical Activity Might Have an Impact on Outcome/Prognosis After a Breast Cancer Diagnosis. 2009, 97-111. DOI: 10.1007/978-1-4419-1173-5_6.Peer-Reviewed Original ResearchBreast cancer survivalBiological markersCancer survivalUrgent public health priorityTrial of exerciseBreast cancer deathsImpact of exercisePublic health priorityOutcome/prognosisBody fat levelsBreast cancer diagnosisEffects of PAPhysical inactivityCancer deathSmall RCTsSex hormonesBreast cancerHealth priorityPhysical activityBody fatHormonal concentrationsBeneficial effectsGrowth factorCancer diagnosisBeneficial changes