2007
Evaluation of Proton Pump Inhibitor Use in Patients With Acute Coronary Syndromes Based on Risk Factors for Gastrointestinal Bleed
Schreiner GC, Laine L, Murphy SA, Cannon CP. Evaluation of Proton Pump Inhibitor Use in Patients With Acute Coronary Syndromes Based on Risk Factors for Gastrointestinal Bleed. Critical Pathways In Cardiology A Journal Of Evidence-Based Medicine 2007, 6: 169-172. PMID: 18091407, DOI: 10.1097/hpc.0b013e318159921e.Peer-Reviewed Original ResearchConceptsUse of PPIsAcute coronary syndromeProton pump inhibitorsGI risk factorsRisk factorsCoronary syndromeHigh GI risk patientsProton pump inhibitor useNonsteroidal anti-inflammatory agentsInfection Therapy-ThrombolysisLong-term bleedingPrior GI eventsDual antiplatelet therapyUse of anticoagulantsAnti-inflammatory agentsAtorvastatin EvaluationAntiplatelet therapyGastrointestinal bleedGastrointestinal bleedingGI bleedingGI eventsInhibitor useRisk patientsTrials databasesPump inhibitors
2004
Utilization of nonsteroidal anti-inflammatory drugs and antisecretory agents: a managed care claims analysis
Ofman JJ, Badamgarav E, Henning JM, Knight K, Laine L. Utilization of nonsteroidal anti-inflammatory drugs and antisecretory agents: a managed care claims analysis. The American Journal Of Medicine 2004, 116: 835-842. PMID: 15178499, DOI: 10.1016/j.amjmed.2004.02.028.Peer-Reviewed Original ResearchConceptsCOX-2 inhibitorsCardiac eventsHealth care costsGastrointestinal bleedingTraditional NSAIDsHigh riskGreater total health care costsNonsteroidal anti-inflammatory drug therapyCare costsAnti-inflammatory drug therapyCOX-2 inhibitor therapyTotal health care costsCyclooxygenase-2 selective inhibitorNonsteroidal anti-inflammatory drugsCardiac risk profileProton pump inhibitorsAnti-inflammatory drugsLogistic regression analysisNSAID therapyNSAID usersGastrointestinal riskInhibitor useNonselective NSAIDsInhibitor therapyCardiac risk
2003
Proton pump inhibitor use in patients with indications for low-dose aspirin who start COX-2 selective inhibitors or nonselective NSAIDs
Ofman J, Knight K, Badamgarav E, Henning J, Wallace K, Wong J, Dylan M, Laine L. Proton pump inhibitor use in patients with indications for low-dose aspirin who start COX-2 selective inhibitors or nonselective NSAIDs. Gastroenterology 2003, 124: a107. DOI: 10.1016/s0016-5085(03)80529-2.Peer-Reviewed Original Research
2000
Review article: potential gastrointestinal effects of long‐term acid suppression with proton pump inhibitors
Laine, Ahnen, Mcclain, Solcia, Walsh. Review article: potential gastrointestinal effects of long‐term acid suppression with proton pump inhibitors. Alimentary Pharmacology & Therapeutics 2000, 14: 651-668. PMID: 10848649, DOI: 10.1046/j.1365-2036.2000.00768.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsProton pump inhibitor useProton pump inhibitorsLong-term acid suppressionGastric acid suppressionAcid suppressionPump inhibitorsInhibitor useBacterial overgrowthEnteric infectionsGastric adenocarcinomaHigh-dose proton pump inhibitorsCarcinoid formationLong-term proton pump inhibitor useEnterochromaffin-like cell hyperplasiaAdverse effectsChronic acid suppressionImportant clinical sequelaeLong-term protonGastrointestinal adverse effectsMalabsorption of fatVitamin B12 levelsCommon clinical problemH. pylori infectionVitamin B12 concentrationsGastric bacterial overgrowth