2024
Clinical challenges and advancements in diagnosing Staphylococcus aureus-associated musculoskeletal infections
Oh I. Clinical challenges and advancements in diagnosing Staphylococcus aureus-associated musculoskeletal infections. Kosin Medical Journal 2024, 39: 5-17. DOI: 10.7180/kmj.24.104.Peer-Reviewed Original ResearchMusculoskeletal infectionsS. aureus immune evasionIdentification of pathogensNext-generation sequencingConventional culture methodsComplicated clinical decisionsDevelopment of innovative diagnosticsPeripheral blood mononuclear cellsRemoval of infected implantsErythrocyte sedimentation rateMonitoring treatment responseTranscriptome of peripheral blood mononuclear cellsBlood mononuclear cellsC-reactive proteinFalse-negative resultsStaphylococcus aureusDominant pathogenAntibiotic therapySurgical debridementAbscess formationInfected implantsInflammatory markersAggressive debridementInfected tissuesOrthopedic infectionsBiomechanical Effects of Subtalar Joint Fusion and Medial Ligament Reconstruction in Simulated Progressive Collapsing Foot Deformity
Lee W, Tecle N, Knapp E, Awad H, Oh I. Biomechanical Effects of Subtalar Joint Fusion and Medial Ligament Reconstruction in Simulated Progressive Collapsing Foot Deformity. Foot & Ankle International 2024, 45: 279-290. PMID: 38240174, DOI: 10.1177/10711007231220940.Peer-Reviewed Original ResearchMedial displacement calcaneal osteotomyProgressive collapsing foot deformitySubtalar joint fusionSevere flatfoot modelFlatfoot modelHeel alignmentValgus tiltMedial ligament reconstructionFoot deformityFresh-frozen cadaveric foot specimensJoint fusionLigament strainBiomechanical effectsTalo-first metatarsal angleCadaveric foot specimensLigament reconstructionSubtalar angleFoot alignmentFoot malalignmentForefoot abductionMetatarsal angleTibiotalar angleTibiotalar tiltFoot specimensCalcaneal osteotomy
2023
Utilization of PROMIS Neuropathic Pain Quality for Detection and Monitoring Neuropathic Pain in Heel Pain Patients
Joo P, Lee W, Hoffman S, Baumhauer J, Oh I. Utilization of PROMIS Neuropathic Pain Quality for Detection and Monitoring Neuropathic Pain in Heel Pain Patients. Foot & Ankle Orthopaedics 2023, 8: 24730114231213620. PMID: 38058978, PMCID: PMC10697051, DOI: 10.1177/24730114231213620.Peer-Reviewed Original ResearchBody mass indexNeuropathic painPhysical functionNeuropathic pain qualitiesPain interferencePain patientsPain qualityBack/neck painPrevalence of NPWorse pain interferenceOnly independent factorProspective cohort studyTime pointsLow physical functionAnxiety/depressionNeck painHeel painCohort studyAnkle patientsMass indexMean ageInitial screening toolLinear mixed modelingIndependent factorsSelf-efficacy scoresClinical presentation of group B Streptococcus-infected diabetic foot ulcers
Waldman O, Dexter B, Sulovari A, Oh I. Clinical presentation of group B Streptococcus-infected diabetic foot ulcers. Journal Of Wound Care 2023, 32: s19-s25. PMID: 37405964, DOI: 10.12968/jowc.2023.32.sup7.s19.Peer-Reviewed Original ResearchConceptsDiabetic foot ulcersFoot ulcersBlack patientsRecurrent infectionsElevated hemoglobin A1cIntra-operative culturesHemoglobin A1c levelsInitial laboratory valuesSoft tissue infectionsDFU infectionsDFU patientsInitial surgeryOrthopaedic FootAggressive treatmentClinical characteristicsGBS infectionA1c levelsHemoglobin A1cTissue infectionsClinical outcomesClinical presentationInfected boneAppropriate treatmentGroup BLaboratory valuesThe Burden of Revision Total Ankle Replacement Has Increased From 2010 to 2020
Ratnasamy P, Maloy G, Oghenesume O, Peden S, Grauer J, Oh I. The Burden of Revision Total Ankle Replacement Has Increased From 2010 to 2020. Foot & Ankle Orthopaedics 2023, 8: 24730114231198234. PMID: 37767009, PMCID: PMC10521287, DOI: 10.1177/24730114231198234.Peer-Reviewed Original ResearchElixhauser Comorbidity IndexHigher Elixhauser comorbidity indexRetrospective cohort studyCohort studyIndependent predictorsAnnual incidenceRevision surgeryRisk factorsYounger ageMultivariate logistic regression analysisRevision total ankle replacementTotal ankle replacement surgeryIndependent risk factorImplant survival rateTiming of revisionLogistic regression analysisSite of careTotal ankle replacementAnkle replacement surgeryExplant patientsExplant surgeryComorbidity indexPatient factorsIndex procedureFemale sexTranscriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection
Agidigbi T, Kwon H, Knight J, Zhao D, Lee F, Oh I. Transcriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection. Frontiers In Cellular And Infection Microbiology 2023, 13: 1198115. PMID: 37434783, PMCID: PMC10332306, DOI: 10.3389/fcimb.2023.1198115.Peer-Reviewed Original ResearchConceptsDiabetic foot ulcersPeripheral blood mononuclear cellsHost immune responseActive infectionImmune responseDiabetic foot ulcer infectionsInfected diabetic foot ulcersFoot ulcer infectionsPatients 8 weeksIntravenous antibiotic therapyBlood mononuclear cellsWound healing statusDFU infectionsPBMC expressionSalvage therapyUlcer infectionDifferent time pointsAntibiotic therapyMajor complicationsSurgical treatmentFoot ulcersMononuclear cellsPotential intervention optionsSpecies-specific infectionTreatment responseClinical Improvement Following Operative Management of Ankle Fractures Among Patients With and Without Moderate to High Depressive Symptoms: An Analysis Using PROMIS
Bernstein D, Ramirez G, Thirukumaran C, Flemister A, Oh I, Ketz J, Baumhauer J. Clinical Improvement Following Operative Management of Ankle Fractures Among Patients With and Without Moderate to High Depressive Symptoms: An Analysis Using PROMIS. Foot & Ankle Orthopaedics 2023, 8: 24730114221151077. PMID: 36741681, PMCID: PMC9893091, DOI: 10.1177/24730114221151077.Peer-Reviewed Original ResearchHigher depressive symptomsPROMIS Physical FunctionPreoperative time pointAnkle fracturesPhysical functionDepressive symptomsPain interferenceOperative managementTime pointsOutcomes Measurement Information System Physical FunctionPatient recovery patternsAnkle fracture surgeryCase-control studyLinear mixed-effects regression modelsLower depressive symptomsMixed effects regression modelsPaucity of literatureClinical improvementRoutine careFracture surgeryDepression QuestionnaireInclusion criteriaPatient expectationsPatientsDepression symptoms
2022
Concurrent targeting of glycolysis in bacteria and host cell inflammation in septic arthritis
Kwon H, Yu K, Cahill S, Alder K, Dussik C, Kim S, Sharma L, Back J, Oh I, Lee F. Concurrent targeting of glycolysis in bacteria and host cell inflammation in septic arthritis. EMBO Molecular Medicine 2022, 14: emmm202115284. PMID: 36354099, PMCID: PMC9728052, DOI: 10.15252/emmm.202115284.Peer-Reviewed Original ResearchConceptsDrug dimethyl fumarateSeptic arthritisIntracellular MRSABacterial joint infectionSoft tissue infectionsAnti-inflammatory effectsInfection-associated inflammationNovel therapeutic paradigmContext of infectionConventional antibiotic treatmentHost cellsAdjuvant administrationSurgical treatmentTissue infectionsClinical symptomsInflammatory machineryJoint infectionBacterial burdenAntibiotic treatmentCell inflammationHost inflammationArthritisInflammationIntraarticular inflammationTherapeutic paradigmEmergency Department Visits Within 90 Days of Total Ankle Replacement
Ratnasamy PP, Kammien AJ, Gouzoulis MJ, Oh I, Grauer JN. Emergency Department Visits Within 90 Days of Total Ankle Replacement. Foot & Ankle Orthopaedics 2022, 7: 24730114221134255. PMID: 36324696, PMCID: PMC9619275, DOI: 10.1177/24730114221134255.Peer-Reviewed Original ResearchElixhauser Comorbidity IndexSurgical site painRetrospective cohort studyED visitsSite painCohort studyHealth care utilization/costsHigher Elixhauser comorbidity indexPain management pathwayPostoperative ED visitsPostoperative hospital lengthEmergency department visitsDay of surgeryLogistic regression analysisSite of careTotal ankle replacementHealth care costsComorbidity indexHospital lengthED utilizationDepartment visitsPatient factorsPostoperative weekEmergency departmentFemale sexCan We Utilize PROMIS Neuropathic Pain Quality for Assessment of Neuropathic Heel Pain?
Joo P, Hoffman S, Baumhauer J, Oh I. Can We Utilize PROMIS Neuropathic Pain Quality for Assessment of Neuropathic Heel Pain? Foot & Ankle Orthopaedics 2022, 7: 2473011421s00713. PMCID: PMC9666847, DOI: 10.1177/2473011421s00713.Peer-Reviewed Original ResearchBody mass indexBack/neck painNeuropathic painSevere neuropathic painHeel painNeuropathic pain qualitiesPhysical functionPain interferenceT-scoreNeck painPain qualityOnly significant independent factorTertiary care academic institutionLow physical functionOutcomes Measurement Information SystemSignificant independent factorsMeasurement Information SystemNeuropathic mechanismsCurrent smokersMost etiologiesNociceptive painSecondary outcomesCommon presentationInitial visitPain managementHome and Outpatient Physical Therapy Utilization Following Total Ankle Replacement
Ratnasamy P, Gouzoulis M, Kammien A, Oh I, Grauer J. Home and Outpatient Physical Therapy Utilization Following Total Ankle Replacement. Foot & Ankle Orthopaedics 2022, 7: 24730114221146175. PMID: 36582653, PMCID: PMC9793015, DOI: 10.1177/24730114221146175.Peer-Reviewed Original ResearchTotal ankle replacementRetrospective cohort studyElixhauser Comorbidity IndexPhysical therapyCohort studyPatient factorsTAR patientsAnkle replacementPhysical therapy utilizationDay of surgeryInpatient physical therapyLogistic regression analysisFrequency of homeComorbidity indexIndependent predictorsMedicaid insurancePatients surgeryPredictive factorsTherapy utilizationCare pathwayAdministrative codingSurgeryLevel IIIPatientsFirst weekTreating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive Inflammation
Kwon HK, Dussik CM, Kim SH, Kyriakides TR, Oh I, Lee FY. Treating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive Inflammation. Frontiers In Cellular And Infection Microbiology 2022, 12: 897291. PMID: 35755835, PMCID: PMC9218192, DOI: 10.3389/fcimb.2022.897291.Peer-Reviewed Original ResearchConceptsSeptic arthritisBacterial burdenAntibiotic treatmentMurine modelTherapeutic goalsConcurrent antimicrobial therapyDistinct therapeutic goalsGeneration of inflammationMRSA septic arthritisSeptic knee arthritisInflammatory joint conditionsArticular cartilageMitigation of inflammationPost-antibiotic treatmentNovel therapeutic strategiesSeptic arthritis modelArticular cartilage damageEx vivo modelArticular cartilage integrityInflammatory arthritisInhibitors of ERKInflammatory profileMRSA infectionSynovial tissueExcessive inflammationComparison of Physical Function and Pain Levels of Hallux Rigidus Patients before and after Synthetic Cartilage Implant vs Arthrodesis Surgery
Oh I, Joo P, Baumhauer J, Houck J, Kohring J, Flemister A, Ketz J, DiGiovanni B. Comparison of Physical Function and Pain Levels of Hallux Rigidus Patients before and after Synthetic Cartilage Implant vs Arthrodesis Surgery. Foot & Ankle Orthopaedics 2022, 7: 2473011421s00381. PMCID: PMC8793603, DOI: 10.1177/2473011421s00381.Peer-Reviewed Original ResearchSynthetic cartilage implant hemiarthroplastyPostoperative physical functionPhysical functionSCI cohortT-scoreHallux rigidusAD cohortHallux rigidus patientsPain Interference LevelsPainful degenerative conditionsSynthetic cartilage implantPatients' physical functionTime pointsOutcomes Measurement Information SystemPROMIS T-scoresMeasurement Information SystemQuality of lifePhone surveyArthrodesis surgeryArthrodesis groupFinal followPain levelsComplication ratePROMIS scoresSCI groupPeritalar Kinematics Restored with Combined Subtalar Fusion and Medial Ligament Reconstruction in a Simulated Advance Progressive Collapsing Flatfoot Deformity Model
Tecle N, Oh I, Gira E, Awad H. Peritalar Kinematics Restored with Combined Subtalar Fusion and Medial Ligament Reconstruction in a Simulated Advance Progressive Collapsing Flatfoot Deformity Model. Foot & Ankle Orthopaedics 2022, 7: 2473011421s00470. PMCID: PMC8793585, DOI: 10.1177/2473011421s00470.Peer-Reviewed Original ResearchMedializing calcaneal osteotomySubtalar fusionLigament reconstructionValgus angleSevere flatfoot modelHeel alignmentFlatfoot modelMeary's angleCoronal angleMedial ankle ligamentsMedial ligament reconstructionSequential surgical proceduresMultiple comparison testCadaveric foot specimensTibiotalar osteoarthritisTibiotalar angleMedial archValgus alignmentTibiotalar jointFlatfoot deformityHindfoot alignmentAnkle ligamentsSurgical proceduresCalcaneal osteotomyMedial stabilityIs There a Difference in PROMIS Outcomes Between Patients Who Received K-Wire or Intramedullary Implant PIP Joint Arthrodesis for Hammertoe Deformity?
Holleran A, Homeier D, Baumhauer J, Flemister A, Oh I, DiGiovanni B, Ramirez G, Thirukumaran C, Ketz J. Is There a Difference in PROMIS Outcomes Between Patients Who Received K-Wire or Intramedullary Implant PIP Joint Arthrodesis for Hammertoe Deformity? Foot & Ankle Orthopaedics 2022, 7: 2473011421s00033. PMCID: PMC8792637, DOI: 10.1177/2473011421s00033.Peer-Reviewed Original ResearchPROMIS Physical FunctionK-wire fixationK-wire groupPain interferenceK-wiresPhysical functionIntramedullary fixationKW groupIM groupIntramedullary implantsRecurrence rateRevision surgeryInclusion criteriaWire fixationHammertoe deformityPF scoresPROMIS PFMedicare/Medicaid insuranceNew intramedullary implantPain interference scoresPIP joint arthrodesisPositive smoking statusPROMIS Pain InterferencePost-operative scoresNumber of reoperationsTalocalcaneal Interosseous Ligament Provides Greatest Talar Stability in the Sagittal Plane.
Smith M, Knapp E, Awad HA, Oh I. Talocalcaneal Interosseous Ligament Provides Greatest Talar Stability in the Sagittal Plane. Foot & Ankle Orthopaedics 2022, 7: 2473011421S00454. PMID: 35097940, PMCID: PMC8793609, DOI: 10.1177/2473011421S00454.Peer-Reviewed Original Research
2021
Next-Generation Sequencing for Pathogen Identification in Infected Foot Ulcers
Choi Y, Oda E, Waldman O, Sajda T, Beck C, Oh I. Next-Generation Sequencing for Pathogen Identification in Infected Foot Ulcers. Foot & Ankle Orthopaedics 2021, 6: 24730114211026933. PMID: 35097461, PMCID: PMC8702686, DOI: 10.1177/24730114211026933.Peer-Reviewed Original ResearchDiabetic foot ulcersFoot infectionsFoot ulcersNext-generation sequencingOrthopedic infectionsInfected diabetic foot ulcersFellowship-trained orthopedic footPostoperative antibiotic treatmentInfected foot ulcersStandard cultureConventional cultureWarrants further investigationManagement of footDFU patientsOrthopaedic FootOperative treatmentKnee amputationAntibiotic treatmentRay amputationOperative procedureAnkle surgeonsCommon pathogensAverage ageCommon microorganismsConcordance ratePhysical Function and Pain Interference Levels of Hallux Rigidus Patients Before and After Synthetic Cartilage Implant vs Arthrodesis Surgery
Joo PY, Baumhauer JF, Waldman O, Hoffman S, Houck J, Kohring JM, Flemister AS, Ketz JP, DiGiovanni BF, Oh I. Physical Function and Pain Interference Levels of Hallux Rigidus Patients Before and After Synthetic Cartilage Implant vs Arthrodesis Surgery. Foot & Ankle International 2021, 42: 1277-1286. PMID: 34024138, DOI: 10.1177/10711007211007843.Peer-Reviewed Original ResearchConceptsSynthetic cartilage implant hemiarthroplastyPostoperative physical functionPain Interference LevelsPhysical functionSCI cohortHallux rigidusHallux rigidus patientsPainful degenerative conditionsPatients' physical functionTime pointsOutcomes Measurement Information SystemQuality of lifeMeasurement Information SystemPhone surveyStudy time frameArthrodesis surgeryArthrodesis groupComplication ratePROMIS scoresCase seriesSCI groupMean ageAD groupLevel IVTreatment groupsComparative study of culture, next‐generation sequencing, and immunoassay for identification of pathogen in diabetic foot ulcer
Lipof JS, Jones CMC, Daiss J, Oh I. Comparative study of culture, next‐generation sequencing, and immunoassay for identification of pathogen in diabetic foot ulcer. Journal Of Orthopaedic Research® 2021, 39: 2638-2645. PMID: 33543785, PMCID: PMC8339135, DOI: 10.1002/jor.25001.Peer-Reviewed Original ResearchConceptsDiabetic foot infectionsMusculoskeletal infectionsNext-generation sequencingS. agalactiaeS. aureusCulture-directed antibioticsDeep musculoskeletal infectionNegative initial culturesProspective observational studyTime of diagnosisDiabetic foot ulcersLimb salvage effortsPeripheral blood samplesYears of ageFoot infectionsSurgical debridementFoot ulcersRecurrent infectionsTreatment successFair correlationIntraoperative samplesObservational studyBlood samplesUseful adjunctOrthopaedic surgeonsArthroscopically Assisted Internal Fixation of Foot and Ankle Fractures: A Systematic Review
Williams CE, Joo P, Oh I, Miller C, Kwon JY. Arthroscopically Assisted Internal Fixation of Foot and Ankle Fractures: A Systematic Review. Foot & Ankle Orthopaedics 2021, 6: 2473011420950214. PMID: 35097419, PMCID: PMC8727837, DOI: 10.1177/2473011420950214.Peer-Reviewed Original ResearchIntra-articular injuriesPatient-reported outcomesRetrospective comparative studyAnkle fracturesCase seriesInternal fixation methodsSystematic reviewAnatomical reductionClinical outcomesAnatomic reductionPoor outcomeInternal fixationCalcaneus fracturesOperative techniqueInclusion criteriaFixation methodsConcomitant intra-articular injuriesComparable functional outcomesCase-control studyIntra-articular pathologyUse of arthroscopyValuable adjunct toolAssisted Internal FixationLeast comparable outcomesRespective study designs