2023
Transcriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection
Agidigbi T, Kwon H, Knight J, Zhao D, Lee F, Oh I. Transcriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection. Frontiers In Cellular And Infection Microbiology 2023, 13: 1198115. PMID: 37434783, PMCID: PMC10332306, DOI: 10.3389/fcimb.2023.1198115.Peer-Reviewed Original ResearchConceptsDiabetic foot ulcersPeripheral blood mononuclear cellsHost immune responseActive infectionImmune responseDiabetic foot ulcer infectionsInfected diabetic foot ulcersFoot ulcer infectionsPatients 8 weeksIntravenous antibiotic therapyBlood mononuclear cellsWound healing statusDFU infectionsPBMC expressionSalvage therapyUlcer infectionDifferent time pointsAntibiotic therapyMajor complicationsSurgical treatmentFoot ulcersMononuclear cellsPotential intervention optionsSpecies-specific infectionTreatment response
2020
Species-Specific Immunoassay Aids Identification of Pathogen and Tracks Infectivity in Foot Infection
Hao SP, Masters EA, Ninomiya MJ, Beck CA, Schwarz EM, Daiss JL, Oh I. Species-Specific Immunoassay Aids Identification of Pathogen and Tracks Infectivity in Foot Infection. Foot & Ankle International 2020, 42: 363-372. PMID: 33161780, PMCID: PMC7946706, DOI: 10.1177/1071100720965136.Peer-Reviewed Original ResearchConceptsFoot infectionsHost immune responseWound healing statusImmune responseHealing statusFoot ulcer patientsProspective comparative studyCulture-positive patientsCulture-negative patientsSpecific serum antibodiesDominant pathogenAnalysis of serumConventional bacterial cultureUlcer patientsMusculoskeletal infectionsSurgical interventionAntibody titersSerum antibodiesTherapeutic responseInfection diagnosisSpecies-specific immunoassaySurgeon's decisionCulture resultsInfectionLevel IISpecies-Specific Immunoassay for Diagnosis and Tracking Treatment Response in Foot and Ankle Infection
Oh I, Hao S, Waldman O, Holleran A, Daiss J. Species-Specific Immunoassay for Diagnosis and Tracking Treatment Response in Foot and Ankle Infection. Foot & Ankle Orthopaedics 2020, 5: 2473011420s00372. PMCID: PMC8702934, DOI: 10.1177/2473011420s00372.Peer-Reviewed Original ResearchAnkle infectionWound healing statusHealing statusDFU patientsOngoing infectionTreatment responseS. aureusDiabetic foot ulcer patientsFellowship-trained orthopedic footFoot ulcer patientsCharacteristic curve analysisDiagnostic toolSpecies-specific immunoassayReliable diagnostic toolOrthopaedic FootSpecific diagnostic toolsUlcer patientsAntibiotic therapyClinical resolutionSurgical treatmentClinical outcomesInitial presentationAntibody titersSerum antibodiesAnkle surgeonsPrediction of post-interventional physical function in diabetic foot ulcer patients using patient reported outcome measurement information system (PROMIS)
Hao SP, Houck JR, Waldman OV, Baumhauer JF, Oh I. Prediction of post-interventional physical function in diabetic foot ulcer patients using patient reported outcome measurement information system (PROMIS). Foot And Ankle Surgery 2020, 27: 224-230. PMID: 32439241, PMCID: PMC7655606, DOI: 10.1016/j.fas.2020.04.009.Peer-Reviewed Original ResearchConceptsPostoperative physical functionDiabetic foot ulcer patientsBaseline physical functionPreoperative PROMIS scoresFoot ulcer patientsDFU patientsPhysical functionUlcer patientsClinical factorsPROMIS scoresSurgical interventionAmputation levelHealing statusPostoperative PROMIS physical functionPatients' physical functionPROMIS Physical FunctionOutcomes Measurement Information SystemPreoperative physical functionRelevant clinical factorsSignificant univariate correlationRank correlation coefficientMeasurement Information SystemChi-squared testWound healing statusDFU population
2019
Preoperative Prediction of Postoperative Physical Function in Infected Diabetic Foot Ulcer Patients
Hao S, Houck J, Waldman O, Baumhauer J, Oh I. Preoperative Prediction of Postoperative Physical Function in Infected Diabetic Foot Ulcer Patients. Foot & Ankle Orthopaedics 2019, 4: 2473011419s00200. PMCID: PMC8696823, DOI: 10.1177/2473011419s00200.Peer-Reviewed Original ResearchPreoperative PROMIS scoresPostoperative PFDFU patientsPROMIS scoresAmputation levelPhysical functionHealing statusDiabetic foot ulcer patientsMultivariate modelPatients' overall functionPostoperative physical functionFoot ulcer patientsPost-operative time pointsChronic renal failurePost-surgical followUnique patient populationOutcomes Measurement Information SystemOrthopaedic surgeon's practiceSignificant univariate correlationUtilization of patientsRank correlation coefficientMeasurement Information SystemQuality of lifeChi-squared testWound healing statusOperative Intervention Does Not Change Pain Perception in Diabetic Foot Ulcer Patients
Waldman O, Houck J, Hao S, Lee N, Baumhauer J, Oh I. Operative Intervention Does Not Change Pain Perception in Diabetic Foot Ulcer Patients. Foot & Ankle Orthopaedics 2019, 4: 2473011419s00435. PMCID: PMC8697213, DOI: 10.1177/2473011419s00435.Peer-Reviewed Original ResearchPatients' physical functionDiabetic foot ulcer patientsFoot ulcer patientsPain interferenceDFU patientsClinical factorsUlcer patientsPROMIS scoresSurgical interventionPROMIS domainsPhysical functionHigh prevalenceHealing statusPre-operative patient educationOnly clinical factorOrigin of painPerception of painChi-square testUnited States populationWound healing statusHindfoot amputationsImpact painInitial A1CFinal followMean follow