2023
Clinical presentation of group B Streptococcus-infected diabetic foot ulcers
Waldman O, Dexter B, Sulovari A, Oh I. Clinical presentation of group B Streptococcus-infected diabetic foot ulcers. Journal Of Wound Care 2023, 32: s19-s25. PMID: 37405964, DOI: 10.12968/jowc.2023.32.sup7.s19.Peer-Reviewed Original ResearchConceptsDiabetic foot ulcersFoot ulcersBlack patientsRecurrent infectionsElevated hemoglobin A1cIntra-operative culturesHemoglobin A1c levelsInitial laboratory valuesSoft tissue infectionsDFU infectionsDFU patientsInitial surgeryOrthopaedic FootAggressive treatmentClinical characteristicsGBS infectionA1c levelsHemoglobin A1cTissue infectionsClinical outcomesClinical presentationInfected boneAppropriate treatmentGroup BLaboratory valuesTranscriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection
Agidigbi T, Kwon H, Knight J, Zhao D, Lee F, Oh I. Transcriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection. Frontiers In Cellular And Infection Microbiology 2023, 13: 1198115. PMID: 37434783, PMCID: PMC10332306, DOI: 10.3389/fcimb.2023.1198115.Peer-Reviewed Original ResearchConceptsDiabetic foot ulcersPeripheral blood mononuclear cellsHost immune responseActive infectionImmune responseDiabetic foot ulcer infectionsInfected diabetic foot ulcersFoot ulcer infectionsPatients 8 weeksIntravenous antibiotic therapyBlood mononuclear cellsWound healing statusDFU infectionsPBMC expressionSalvage therapyUlcer infectionDifferent time pointsAntibiotic therapyMajor complicationsSurgical treatmentFoot ulcersMononuclear cellsPotential intervention optionsSpecies-specific infectionTreatment response
2021
Next-Generation Sequencing for Pathogen Identification in Infected Foot Ulcers
Choi Y, Oda E, Waldman O, Sajda T, Beck C, Oh I. Next-Generation Sequencing for Pathogen Identification in Infected Foot Ulcers. Foot & Ankle Orthopaedics 2021, 6: 24730114211026933. PMID: 35097461, PMCID: PMC8702686, DOI: 10.1177/24730114211026933.Peer-Reviewed Original ResearchDiabetic foot ulcersFoot infectionsFoot ulcersNext-generation sequencingOrthopedic infectionsInfected diabetic foot ulcersFellowship-trained orthopedic footPostoperative antibiotic treatmentInfected foot ulcersStandard cultureConventional cultureWarrants further investigationManagement of footDFU patientsOrthopaedic FootOperative treatmentKnee amputationAntibiotic treatmentRay amputationOperative procedureAnkle surgeonsCommon pathogensAverage ageCommon microorganismsConcordance rateComparative study of culture, next‐generation sequencing, and immunoassay for identification of pathogen in diabetic foot ulcer
Lipof JS, Jones CMC, Daiss J, Oh I. Comparative study of culture, next‐generation sequencing, and immunoassay for identification of pathogen in diabetic foot ulcer. Journal Of Orthopaedic Research® 2021, 39: 2638-2645. PMID: 33543785, PMCID: PMC8339135, DOI: 10.1002/jor.25001.Peer-Reviewed Original ResearchConceptsDiabetic foot infectionsMusculoskeletal infectionsNext-generation sequencingS. agalactiaeS. aureusCulture-directed antibioticsDeep musculoskeletal infectionNegative initial culturesProspective observational studyTime of diagnosisDiabetic foot ulcersLimb salvage effortsPeripheral blood samplesYears of ageFoot infectionsSurgical debridementFoot ulcersRecurrent infectionsTreatment successFair correlationIntraoperative samplesObservational studyBlood samplesUseful adjunctOrthopaedic surgeons
2020
Clinical utilization of species‐specific immunoassays for identification of Staphylococcus aureus and Streptococcus agalactiae in orthopedic infections
Sulovari A, Ninomiya MJ, Beck CA, Ricciardi BF, Ketonis C, Mesfin A, Kaplan NB, Soin SP, McDowell SM, Mahmood B, Daiss JL, Schwarz EM, Oh I. Clinical utilization of species‐specific immunoassays for identification of Staphylococcus aureus and Streptococcus agalactiae in orthopedic infections. Journal Of Orthopaedic Research® 2020, 39: 2141-2150. PMID: 33274775, PMCID: PMC8175449, DOI: 10.1002/jor.24935.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsFracture-related infectionMusculoskeletal infectionsOrthopedic infectionsHigh diagnostic potentialCultured peripheral blood mononuclear cellsDiagnostic potentialDeep musculoskeletal infectionSignificant patient morbidityBlood mononuclear cellsDiabetic foot ulcersAntigen-specific IgGPeriprosthetic joint infectionStaphylococcus aureusInfection patientsSeptic arthritisSurgical treatmentCurrent diagnostic methodsFoot ulcersJoint infectionAntibody titersMononuclear cellsPatient morbidityPolymicrobial infectionsAntibiotic useGroup B Streptococcus Infected Tenosynovitis in Diabetic Foot Ulcers
Waldman O, Sajda T, Oh I, Sulovari A. Group B Streptococcus Infected Tenosynovitis in Diabetic Foot Ulcers. Foot & Ankle Orthopaedics 2020, 5: 2473011420s00483. PMCID: PMC8702881, DOI: 10.1177/2473011420s00483.Peer-Reviewed Original ResearchDiabetic foot ulcersPost-operative complicationsDFU patientsGBS patientsUnplanned readmissionInflammatory markersRay amputationAcute ulcersSurgical treatmentClinical outcomesFoot ulcersRepeat operationSevere soft tissue inflammationInfected diabetic foot ulcersSevere soft tissue damageElevated inflammatory markersHigh inflammatory markersAggressive surgical treatmentSoft tissue inflammationPost-surgical complicationsOrthopaedic surgeon's practiceGroup B streptococciSoft tissue damageBlood glucose valuesFrequent wound complicationsOperative Intervention Does Not Change Pain Perception in Patients With Diabetic Foot Ulcers
Waldman OV, Hao SP, Houck JR, Lee NJ, Baumhauer JF, Oh I. Operative Intervention Does Not Change Pain Perception in Patients With Diabetic Foot Ulcers. Clinical Diabetes 2020, 38: 132-140. PMID: 32327885, PMCID: PMC7164984, DOI: 10.2337/cd19-0031.Peer-Reviewed Original ResearchPostoperative physical functionDiabetic foot ulcersDiabetic peripheral neuropathyPainful diabetic peripheral neuropathyPain interferenceOperative interventionFoot ulcersPain perceptionHealing of DFUsHigher PROMIS PI scoresDepression levelsPercent of patientsMajority of patientsOutcomes Measurement Information SystemPROMIS PI scoresHigher pain interferenceMeasurement Information SystemPeripheral neuropathyPhysical functionDepression domainPI scoresPatientsUlcersInterventionFinal outcome
2019
Evidence of differential microbiomes in healing versus non‐healing diabetic foot ulcers prior to and following foot salvage therapy
MacDonald A, Brodell JD, Daiss JL, Schwarz EM, Oh I. Evidence of differential microbiomes in healing versus non‐healing diabetic foot ulcers prior to and following foot salvage therapy. Journal Of Orthopaedic Research® 2019, 37: 1596-1603. PMID: 30908702, PMCID: PMC6659747, DOI: 10.1002/jor.24279.Peer-Reviewed Original ResearchConceptsSalvage therapyQuantitative polymerase chain reactionClinical outcomesClinical toolErythrocyte sedimentation rateFurther surgical interventionC-reactive proteinLower extremity amputationDiabetic foot ulcersEventual clinical outcomeImportant prognostic informationImportant clinical toolDFU patientsFoot salvageFoot ulcersDiabetic footExtremity amputationSurgical interventionPatient counselingAntibiotic treatmentPolymerase chain reactionPrognostic informationClinical signsMicrobiome analysisClinical significance
2018
Chronic Osteomyelitis with Staphylococcus aureus Deformation in Submicron Canaliculi of Osteocytes
de Mesy Bentley KL, MacDonald A, Schwarz EM, Oh I. Chronic Osteomyelitis with Staphylococcus aureus Deformation in Submicron Canaliculi of Osteocytes. JBJS Case Connector 2018, 8: e8. PMID: 29443819, PMCID: PMC6681818, DOI: 10.2106/jbjs.cc.17.00154.Peer-Reviewed Original Research
2017
Microbiome Analysis for Assessments of Treatment Response and Salvage Prognosis in Infected Diabetic Foot Ulcers
MacDonald A, Oh I, Grier A, Smith B, Daiss J, Gill S. Microbiome Analysis for Assessments of Treatment Response and Salvage Prognosis in Infected Diabetic Foot Ulcers. Foot & Ankle Orthopaedics 2017, 2: 2473011417s000060. DOI: 10.1177/2473011417s000060.Peer-Reviewed Original ResearchIntravenous antibiotic treatmentAntibiotic treatmentNon-traumatic lower extremity amputationsInfected diabetic foot ulcersAdequate prognostic informationPoor prognostic signDiabetic foot ulcersLower extremity amputationSignificant differencesMicrobiome analysisDFU infectionsFoot salvageWagner classificationMedical comorbiditiesCounseling patientsFoot ulcersInitial presentationPrognostic signPrognostic valueActive infectionDiabetic footPrognostic informationClinical signsWeek 8Surgical decision