2024
Clinical challenges and advancements in diagnosing Staphylococcus aureus-associated musculoskeletal infections
Oh I. Clinical challenges and advancements in diagnosing Staphylococcus aureus-associated musculoskeletal infections. Kosin Medical Journal 2024, 39: 5-17. DOI: 10.7180/kmj.24.104.Peer-Reviewed Original ResearchMusculoskeletal infectionsS. aureus immune evasionIdentification of pathogensNext-generation sequencingConventional culture methodsComplicated clinical decisionsDevelopment of innovative diagnosticsPeripheral blood mononuclear cellsRemoval of infected implantsErythrocyte sedimentation rateMonitoring treatment responseTranscriptome of peripheral blood mononuclear cellsBlood mononuclear cellsC-reactive proteinFalse-negative resultsStaphylococcus aureusDominant pathogenAntibiotic therapySurgical debridementAbscess formationInfected implantsInflammatory markersAggressive debridementInfected tissuesOrthopedic infections
2023
Transcriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection
Agidigbi T, Kwon H, Knight J, Zhao D, Lee F, Oh I. Transcriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection. Frontiers In Cellular And Infection Microbiology 2023, 13: 1198115. PMID: 37434783, PMCID: PMC10332306, DOI: 10.3389/fcimb.2023.1198115.Peer-Reviewed Original ResearchConceptsDiabetic foot ulcersPeripheral blood mononuclear cellsHost immune responseActive infectionImmune responseDiabetic foot ulcer infectionsInfected diabetic foot ulcersFoot ulcer infectionsPatients 8 weeksIntravenous antibiotic therapyBlood mononuclear cellsWound healing statusDFU infectionsPBMC expressionSalvage therapyUlcer infectionDifferent time pointsAntibiotic therapyMajor complicationsSurgical treatmentFoot ulcersMononuclear cellsPotential intervention optionsSpecies-specific infectionTreatment response
2020
Species-Specific Immunoassay for Diagnosis and Tracking Treatment Response in Foot and Ankle Infection
Oh I, Hao S, Waldman O, Holleran A, Daiss J. Species-Specific Immunoassay for Diagnosis and Tracking Treatment Response in Foot and Ankle Infection. Foot & Ankle Orthopaedics 2020, 5: 2473011420s00372. PMCID: PMC8702934, DOI: 10.1177/2473011420s00372.Peer-Reviewed Original ResearchAnkle infectionWound healing statusHealing statusDFU patientsOngoing infectionTreatment responseS. aureusDiabetic foot ulcer patientsFellowship-trained orthopedic footFoot ulcer patientsCharacteristic curve analysisDiagnostic toolSpecies-specific immunoassayReliable diagnostic toolOrthopaedic FootSpecific diagnostic toolsUlcer patientsAntibiotic therapyClinical resolutionSurgical treatmentClinical outcomesInitial presentationAntibody titersSerum antibodiesAnkle surgeons
2019
Evolving concepts in bone infection: redefining “biofilm”, “acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”
Masters EA, Trombetta RP, de Mesy Bentley KL, Boyce BF, Gill AL, Gill SR, Nishitani K, Ishikawa M, Morita Y, Ito H, Bello-Irizarry SN, Ninomiya M, Brodell JD, Lee CC, Hao SP, Oh I, Xie C, Awad HA, Daiss JL, Owen JR, Kates SL, Schwarz EM, Muthukrishnan G. Evolving concepts in bone infection: redefining “biofilm”, “acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”. Bone Research 2019, 7: 20. PMID: 31646012, PMCID: PMC6804538, DOI: 10.1038/s41413-019-0061-z.Peer-Reviewed Original ResearchImmune proteomeChronic osteomyelitisBone infectionChronic osteomyelitis casesStaphylococcal abscess communitiesElective orthopaedic surgeryRate of reinfectionHigh patient morbidityLocal antibiotic therapyLocal soft tissueFrequency of infectionDevastating diseaseOsteomyelitis casesAntibiotic therapyCurative treatmentTreatment algorithmOsteomyelitis diagnosisPatient morbiditySerum antibodiesNovel therapiesOsteocyte lacuno-canalicular networkClinical studiesClinical classificationImplant hardwareOsteomyelitis