2022
Defining Clinical and Immunological Predictors of Poor Immune Responses to COVID-19 mRNA Vaccines in Patients with Primary Antibody Deficiency
Shin JJ, Par-Young J, Unlu S, McNamara A, Park HJ, Shin MS, Gee RJ, Doyle H, Afinogenova Y, Zidan E, Kwah J, Russo A, Mamula M, Hsu FI, Catanzaro J, Racke M, Bucala R, Wilen C, Kang I. Defining Clinical and Immunological Predictors of Poor Immune Responses to COVID-19 mRNA Vaccines in Patients with Primary Antibody Deficiency. Journal Of Clinical Immunology 2022, 42: 1137-1150. PMID: 35713752, PMCID: PMC9203263, DOI: 10.1007/s10875-022-01296-4.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, ViralCD8-Positive T-LymphocytesCommon Variable ImmunodeficiencyCOVID-19COVID-19 VaccinesHumansImmunity, CellularImmunoglobulin AImmunoglobulin GMRNA VaccinesPrimary Immunodeficiency DiseasesRNA, MessengerSARS-CoV-2Spike Glycoprotein, CoronavirusVaccinationVaccinesVaccines, SyntheticConceptsCommon variable immune deficiencyT cellsImmune responseIgG responsesCVID patientsMRNA vaccinesB cellsCoronavirus disease 2019 (COVID-19) mRNA vaccinesCOVID-19 mRNA vaccinesBaseline immune profileHistory of autoimmunityPrimary antibody deficiencyT cell responsesCellular immune responsesPoor immune responseVariable immune deficiencyMemory B cellsSARS-CoV-2 spike proteinBaseline IgGCVID diagnosisEM CD8Immunological predictorsPAD cohortSpecific CD4Immune profile
2006
Cysteinyl Leukotrienes Regulate Th2 Cell-Dependent Pulmonary Inflammation
Kim DC, Hsu FI, Barrett NA, Friend DS, Grenningloh R, Ho IC, Al-Garawi A, Lora JM, Lam BK, Austen KF, Kanaoka Y. Cysteinyl Leukotrienes Regulate Th2 Cell-Dependent Pulmonary Inflammation. The Journal Of Immunology 2006, 176: 4440-4448. PMID: 16547282, DOI: 10.4049/jimmunol.176.7.4440.Peer-Reviewed Original ResearchConceptsPulmonary inflammationDelayed-type cutaneous hypersensitivityAg-specific IgECys-LT generationSmooth muscle constrictorTh2 cell cytokinesGoblet cell hyperplasiaIntraepithelial mast cellsCytokine mRNA expressionCell-dependent responsesAirway hyperresponsivenessOVA sensitizationWild-type controlsCutaneous hypersensitivityCys-LTsMucus hypersecretionEosinophil infiltrationCell hyperplasiaCysteinyl leukotrienesCell cytokinesInflammatory responseMast cellsInflammationChallenge protocolMRNA expression