2019
Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy
Panza JA, Ellis AM, Al-Khalidi HR, Holly TA, Berman DS, Oh JK, Pohost GM, Sopko G, Chrzanowski L, Mark DB, Kukulski T, Favaloro LE, Maurer G, Farsky PS, Tan RS, Asch FM, Velazquez EJ, Rouleau JL, Lee KL, Bonow RO. Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy. New England Journal Of Medicine 2019, 381: 739-748. PMID: 31433921, PMCID: PMC6814246, DOI: 10.1056/nejmoa1807365.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery BypassEchocardiography, StressFemaleFollow-Up StudiesHeartHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedMyocardial IschemiaProportional Hazards ModelsProspective StudiesStroke VolumeTomography, Emission-Computed, Single-PhotonTreatment OutcomeVentricular Function, LeftConceptsLeft ventricular ejection fractionVentricular ejection fractionMedical therapyEjection fractionMyocardial viabilityIschemic cardiomyopathyLeft ventricular systolic functionGoals of revascularizationCoronary artery bypassPrimary end pointVentricular systolic functionCoronary artery diseaseLeft ventricular functionLong-term outcomesLong-term survivalSurgical revascularizationDobutamine echocardiographyMedian durationSystolic functionArtery diseaseVentricular functionViable myocardiumLong-term benefitsLower incidenceCABG
2015
Severity of Remodeling, Myocardial Viability, and Survival in Ischemic LV Dysfunction After Surgical Revascularization
Bonow RO, Castelvecchio S, Panza JA, Berman DS, Velazquez EJ, Michler RE, She L, Holly TA, Desvigne-Nickens P, Kosevic D, Rajda M, Chrzanowski L, Deja M, Lee KL, White H, Oh JK, Doenst T, Hill JA, Rouleau JL, Menicanti L, Investigators S. Severity of Remodeling, Myocardial Viability, and Survival in Ischemic LV Dysfunction After Surgical Revascularization. JACC Cardiovascular Imaging 2015, 8: 1121-1129. PMID: 26363840, PMCID: PMC4633018, DOI: 10.1016/j.jcmg.2015.03.013.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery BypassCoronary Artery DiseaseEchocardiography, StressFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMyocardiumPredictive Value of TestsProportional Hazards ModelsProspective StudiesRecovery of FunctionRisk FactorsStroke VolumeTime FactorsTissue SurvivalTomography, Emission-Computed, Single-PhotonTreatment OutcomeUnited StatesVentricular Dysfunction, LeftVentricular Function, LeftVentricular RemodelingConceptsEnd-systolic volume indexEnd-systolic volumeEffect of CABGIschemic LV dysfunctionMedical therapyMyocardial viabilityLV dysfunctionViable myocardiumLV end-systolic volume indexMedian end-systolic volume indexSmaller end-systolic volumeCoronary artery bypassLV systolic dysfunctionMarker of severityCoronary artery diseaseLeft ventricular remodelingPre-specified criteriaSingle photon emissionSTICH trialSurgical revascularizationArtery bypassDobutamine echocardiographySystolic dysfunctionArtery diseaseIschemic cardiomyopathy
2014
Myocardial viability and impact of surgical ventricular reconstruction on outcomes of patients with severe left ventricular dysfunction undergoing coronary artery bypass surgery: Results of the Surgical Treatment for Ischemic Heart Failure trial
Holly TA, Bonow RO, Arnold JM, Oh JK, Varadarajan P, Pohost GM, Haddad H, Jones RH, Velazquez EJ, Birkenfeld B, Asch FM, Malinowski M, Barretto R, Kalil RA, Berman DS, Sun JL, Lee KL, Panza JA. Myocardial viability and impact of surgical ventricular reconstruction on outcomes of patients with severe left ventricular dysfunction undergoing coronary artery bypass surgery: Results of the Surgical Treatment for Ischemic Heart Failure trial. Journal Of Thoracic And Cardiovascular Surgery 2014, 148: 2677-2684.e1. PMID: 25152476, PMCID: PMC4250319, DOI: 10.1016/j.jtcvs.2014.06.090.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiomyopathiesCoronary Artery BypassCoronary Artery DiseaseFemaleHeart FailureHumansKaplan-Meier EstimateMaleMiddle AgedMyocardiumPlastic Surgery ProceduresPredictive Value of TestsProportional Hazards ModelsSeverity of Illness IndexTime FactorsTissue SurvivalTomography, Emission-Computed, Single-PhotonTreatment OutcomeVentricular Dysfunction, LeftVentricular Function, LeftConceptsSurgical ventricular reconstructionCoronary artery bypass graft surgeryIschemic Heart Failure (STICH) trialArtery bypass graft surgeryCoronary artery bypass surgeryBypass graft surgeryHeart Failure TrialArtery bypass surgeryLeft ventricular dysfunctionCoronary artery diseaseType of surgeryCardiac hospitalizationVentricular reconstructionVentricular dysfunctionMyocardial viabilitySurgical treatmentGraft surgeryBypass surgeryArtery diseaseFailure TrialSevere regional left ventricular dysfunctionSevere left ventricular dysfunctionRegional left ventricular dysfunctionOutcomes of patientsIschemic heart failure
2012
Influence of baseline left ventricular function on the clinical outcome of surgical ventricular reconstruction in patients with ischaemic cardiomyopathy
Oh JK, Velazquez EJ, Menicanti L, Pohost GM, Bonow RO, Lin G, Hellkamp AS, Ferrazzi P, Wos S, Rao V, Berman D, Bochenek A, Cherniavsky A, Rogowski J, Rouleau JL, Lee KL, Investigators O. Influence of baseline left ventricular function on the clinical outcome of surgical ventricular reconstruction in patients with ischaemic cardiomyopathy. European Heart Journal 2012, 34: 39-47. PMID: 22584648, PMCID: PMC3533917, DOI: 10.1093/eurheartj/ehs021.Peer-Reviewed Original ResearchConceptsEnd-systolic volume indexSurgical ventricular reconstructionRegional wall motion abnormalitiesWall motion abnormalitiesEjection fractionBetter LVEFIschemic cardiomyopathyVentricular reconstructionMotion abnormalitiesLV end-systolic volume indexMedian end-systolic volume indexBaseline left ventricular functionIschemic Heart Failure (STICH) trialEnd-diastolic volume indexVolume indexBaseline LV functionCoronary artery bypassHeart Failure TrialLeft ventricular functionClinical trial registrationLeft ventricular function parametersLV global functionVentricular function parametersCardiovascular magnetic resonanceML/m2
2011
Myocardial Viability and Survival in Ischemic Left Ventricular Dysfunction
Bonow RO, Maurer G, Lee KL, Holly TA, Binkley PF, Desvigne-Nickens P, Drozdz J, Farsky PS, Feldman AM, Doenst T, Michler RE, Berman DS, Nicolau JC, Pellikka PA, Wrobel K, Alotti N, Asch FM, Favaloro LE, She L, Velazquez EJ, Jones RH, Panza JA. Myocardial Viability and Survival in Ischemic Left Ventricular Dysfunction. New England Journal Of Medicine 2011, 364: 1617-1625. PMID: 21463153, PMCID: PMC3290901, DOI: 10.1056/nejmoa1100358.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiovascular DiseasesCombined Modality TherapyCoronary Artery BypassCoronary Artery DiseaseEchocardiography, StressFemaleFollow-Up StudiesHeart FailureHumansKaplan-Meier EstimateMaleMiddle AgedMyocardial IschemiaMyocardiumProportional Hazards ModelsStatistics, NonparametricTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, LeftConceptsCoronary artery diseaseVentricular dysfunctionMedical therapyMyocardial viabilityArtery diseaseViable myocardiumSurvival benefitBaseline variablesIschemic left ventricular dysfunctionDifferential survival benefitSubstudy of patientsCoronary artery bypassLeft ventricular dysfunctionDobutamine echocardiographyUnderwent assessmentPatientsCABGDysfunctionTreatment assignmentTherapyMyocardiumDiseaseGreater likelihoodMortalityTrials
2010
The STICH trial: evidence‐based conclusions
Rouleau JL, Michler RE, Velazquez EJ, Oh JK, O'Connor CM, Desvigne‐Nickens P, Sopko G, Lee KL, Jones RH. The STICH trial: evidence‐based conclusions. European Journal Of Heart Failure 2010, 12: 1028-1030. PMID: 20861132, DOI: 10.1093/eurjhf/hfq140.Peer-Reviewed Original Research
2009
Use of phase analysis of gated SPECT perfusion imaging to quantify dyssynchrony in patients with mild-to-moderate left ventricular dysfunction
Atchley AE, Trimble MA, Samad Z, Shaw LK, Pagnanelli R, Chen J, Garcia EV, Iskandrian AE, Velazquez EJ, Borges-Neto S. Use of phase analysis of gated SPECT perfusion imaging to quantify dyssynchrony in patients with mild-to-moderate left ventricular dysfunction. Journal Of Nuclear Cardiology 2009, 16: 888-894. PMID: 19690935, PMCID: PMC3048054, DOI: 10.1007/s12350-009-9136-3.Peer-Reviewed Original ResearchConceptsModerate LV dysfunctionSevere LV dysfunctionLV dysfunctionMechanical dyssynchronyQRS durationNormal controlsGated SPECTModerate left ventricular dysfunctionNYHA class IIIPrevalence of dyssynchronyLeft ventricular dysfunctionCohort of patientsMajority of patientsLV mechanical dyssynchronyGated SPECT imagingCurrent selection criteriaLess dyssynchronyLVEF 35More dyssynchronyVentricular dysfunctionPatient selectionDyssynchronyPatientsSPECT perfusionDysfunction
2008
Left Ventricular Mechanical Dyssynchrony as Assessed by Phase Analysis of ECG‐Gated SPECT Myocardial Perfusion Imaging
Chen J, Garcia EV, Lerakis S, Henneman MM, Bax JJ, Trimble MA, Borges‐Neto S, Velazquez EJ, Iskandrian AE. Left Ventricular Mechanical Dyssynchrony as Assessed by Phase Analysis of ECG‐Gated SPECT Myocardial Perfusion Imaging. Echocardiography 2008, 25: 1186-1194. PMID: 18986406, DOI: 10.1111/j.1540-8175.2008.00782.x.Peer-Reviewed Original ResearchMeSH KeywordsElectrocardiographyHumansMyocardial Perfusion ImagingPredictive Value of TestsTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, LeftConceptsCardiac resynchronization therapyMyocardial perfusion imagingTissue Doppler imagingLV dyssynchronyPerfusion imagingTomography myocardial perfusion imagingSPECT myocardial perfusion imagingElectrocardiography-gated single-photon emissionSevere heart failureVentricular mechanical dyssynchronySingle photon emissionHeart failureMechanical dyssynchronyResynchronization therapyClinical evaluationDyssynchronyLeft ventricleDoppler imagingPatientsRegional wallMechanical contractionPhoton emissionCardiac cycleImportant predictorFourier harmonic functionsEvaluation of mechanical dyssynchrony and myocardial perfusion using phase analysis of gated SPECT imaging in patients with left ventricular dysfunction
Trimble MA, Borges-Neto S, Honeycutt EF, Shaw LK, Pagnanelli R, Chen J, Iskandrian AE, Garcia EV, Velazquez EJ. Evaluation of mechanical dyssynchrony and myocardial perfusion using phase analysis of gated SPECT imaging in patients with left ventricular dysfunction. Journal Of Nuclear Cardiology 2008, 15: 663-670. PMID: 18761269, PMCID: PMC3048059, DOI: 10.1016/j.nuclcard.2008.06.007.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiac Pacing, ArtificialCoronary Artery DiseaseEchocardiographyFemaleGated Blood-Pool ImagingHeart FailureHumansMaleMiddle AgedMyocardiumPerfusionRetrospective StudiesTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, LeftConceptsLeft ventricular dysfunctionMechanical dyssynchronyQRS durationPhase SDHF patientsVentricular dysfunctionPerfusion abnormalitiesMyocardial perfusionGated SPECT myocardial perfusion imagingLV phase distributionPhase analysis indicesSPECT myocardial perfusion imagingHeart failure patientsCardiac resynchronization therapyMeasures of dyssynchronyMyocardial perfusion imagingSingle photon emissionLV dysfunctionFailure patientsResynchronization therapyEjection fractionElectrical dyssynchronyMyocardial functionDyssynchronyMyocardial thickeningEmerging Role of Myocardial Perfusion Imaging to Evaluate Patients for Cardiac Resynchronization Therapy††Conflicts of interest: Dr. Garcia has an ownership interest in and serves as a consultant and advisory board member for Syntermed, Inc., Atlanta, Georgia. Dr. Garcia also receives royalties from the sale of clinical software that was used as part of this research. Dr. Borges-Neto and Dr. Trimble have received research support from the Duke-Medtronic Strategic Alliance, which funded some of the studies reviewed in this report.
Trimble MA, Borges-Neto S, Velazquez EJ, Chen J, Shaw LK, Pagnanelli R, Garcia EV, Iskandrian AE. Emerging Role of Myocardial Perfusion Imaging to Evaluate Patients for Cardiac Resynchronization Therapy††Conflicts of interest: Dr. Garcia has an ownership interest in and serves as a consultant and advisory board member for Syntermed, Inc., Atlanta, Georgia. Dr. Garcia also receives royalties from the sale of clinical software that was used as part of this research. Dr. Borges-Neto and Dr. Trimble have received research support from the Duke-Medtronic Strategic Alliance, which funded some of the studies reviewed in this report. The American Journal Of Cardiology 2008, 102: 211-217. PMID: 18602524, DOI: 10.1016/j.amjcard.2008.03.043.Peer-Reviewed Original ResearchMeSH KeywordsCardiac Pacing, ArtificialHeart VentriclesHumansMyocardial ReperfusionSystoleTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, LeftConceptsCardiac resynchronization therapyMechanical dyssynchronyElectrical dyssynchronyMyocardial perfusionSignificant heart failure symptomsTomographic myocardial perfusion imagingLV functional improvementHeart failure symptomsLV systolic dysfunctionSevere LV dysfunctionSelection of patientsManagement of patientsLV mechanical dyssynchronyLeft ventricular dyssynchronyMyocardial perfusion imagingCurrent selection criteriaLV dysfunctionSystolic dysfunctionEchocardiographic measuresResynchronization therapyVentricular dyssynchronyCardiac resynchronizationClinical statusLV remodelingFailure symptomsMeasuring left ventricular mechanical dyssynchrony from ECG-gated SPECT myocardial perfusion imaging.
Chen J, Garcia EV, Henneman MM, Bax JJ, Boogers MJ, Trimble MA, Borges-Neto S, Velazquez EJ, Iskandrian AE. Measuring left ventricular mechanical dyssynchrony from ECG-gated SPECT myocardial perfusion imaging. Minerva Cardioangiologica 2008, 56: 227-35. PMID: 18319701.Peer-Reviewed Original ResearchMeSH KeywordsElectrocardiographyGated Blood-Pool ImagingHeart FailureHumansImage Interpretation, Computer-AssistedPacemaker, ArtificialPrognosisSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, LeftConceptsCardiac resynchronization therapyTissue Doppler imagingMyocardial perfusion imagingLV dyssynchronyECG-gated SPECT myocardial perfusion imagingPerfusion imagingCardiac resynchronization therapy (CRT) trialsMyocardial strain-rate imagingTomography myocardial perfusion imagingClinical validationAvailable echocardiographic techniquesSPECT myocardial perfusion imagingSevere heart failureVentricular mechanical dyssynchronyPredictors of responseRoutine clinical practiceStrain rate imagingSingle photon emissionEntire left ventricleHeart failureMechanical dyssynchronyResynchronization therapyEchocardiographic techniquesDyssynchronyClinical practiceRepeatability and reproducibility of phase analysis of gated single-photon emission computed tomography myocardial perfusion imaging used to quantify cardiac dyssynchrony
Trimble MA, Velazquez EJ, Adams GL, Honeycutt EF, Pagnanelli RA, Barnhart HX, Chen J, Iskandrian AE, Garcia EV, Borges-Neto S. Repeatability and reproducibility of phase analysis of gated single-photon emission computed tomography myocardial perfusion imaging used to quantify cardiac dyssynchrony. Nuclear Medicine Communications 2008, 29: 374-381. PMID: 18317303, PMCID: PMC3048057, DOI: 10.1097/mnm.0b013e3282f81380.Peer-Reviewed Original ResearchMeSH KeywordsFemaleGated Blood-Pool ImagingHumansImage EnhancementImage Interpretation, Computer-AssistedMaleMiddle AgedPerfusionReproducibility of ResultsSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, LeftConceptsSingle photon emissionLeft ventricular dysfunctionTomography perfusion imagingPhase standard deviationNormal controlsPerfusion imagingVentricular dysfunctionTomography myocardial perfusion imagingMyocardial perfusion imagingIntraclass correlation coefficientCardiac dyssynchronyDyssynchronyPatientsInterobserver comparisonsIntraobserver comparisonsDysfunctionPhase indexMean absolute differenceImaging
2003
Radionuclide viability testing: should it affect treatment strategy in patients with cardiomyopathy and significant coronary artery disease?
Bourque JM, Velazquez EJ, Borges-Neto S, Shaw LK, Whellan DJ, O’Connor C. Radionuclide viability testing: should it affect treatment strategy in patients with cardiomyopathy and significant coronary artery disease? American Heart Journal 2003, 145: 758-767. PMID: 12766731, DOI: 10.1016/s0002-8703(02)94818-0.Peer-Reviewed Original ResearchMeSH KeywordsCoronary DiseaseFemaleFluorodeoxyglucose F18Heart FailureHumansMaleMyocardial RevascularizationProspective StudiesRadiopharmaceuticalsRetrospective StudiesSurvival RateThallium RadioisotopesTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, LeftConceptsSignificant coronary artery diseaseCoronary artery diseaseLong-term mortalityArtery diseaseSurvival rateHeart failureTreatment strategiesImpaired left ventricular functionLong-term mortality ratesIschemic heart failureLeft ventricular functionIntermediate survival ratesNuclear imaging studiesLack of randomizationLower survival rateEjection fractionVentricular functionViable myocardiumReferral biasStudy protocolTreatment allocationLarge cohortPrognostic studiesMortality ratePatients