2019
Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy
Panza JA, Ellis AM, Al-Khalidi HR, Holly TA, Berman DS, Oh JK, Pohost GM, Sopko G, Chrzanowski L, Mark DB, Kukulski T, Favaloro LE, Maurer G, Farsky PS, Tan RS, Asch FM, Velazquez EJ, Rouleau JL, Lee KL, Bonow RO. Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy. New England Journal Of Medicine 2019, 381: 739-748. PMID: 31433921, PMCID: PMC6814246, DOI: 10.1056/nejmoa1807365.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery BypassEchocardiography, StressFemaleFollow-Up StudiesHeartHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedMyocardial IschemiaProportional Hazards ModelsProspective StudiesStroke VolumeTomography, Emission-Computed, Single-PhotonTreatment OutcomeVentricular Function, LeftConceptsLeft ventricular ejection fractionVentricular ejection fractionMedical therapyEjection fractionMyocardial viabilityIschemic cardiomyopathyLeft ventricular systolic functionGoals of revascularizationCoronary artery bypassPrimary end pointVentricular systolic functionCoronary artery diseaseLeft ventricular functionLong-term outcomesLong-term survivalSurgical revascularizationDobutamine echocardiographyMedian durationSystolic functionArtery diseaseVentricular functionViable myocardiumLong-term benefitsLower incidenceCABGSpeckle Tracking Analysis of Left Ventricular Systolic Function Following Traumatic Brain Injury: A Pilot Prospective Observational Cohort Study
Krishnamoorthy V, Chaikittisilpa N, Lee J, Mackensen GB, Gibbons EF, Laskowitz D, Hernandez A, Velazquez E, Lele AV, Vavilala MS. Speckle Tracking Analysis of Left Ventricular Systolic Function Following Traumatic Brain Injury: A Pilot Prospective Observational Cohort Study. Journal Of Neurosurgical Anesthesiology 2019, 32: 156-161. PMID: 30676403, PMCID: PMC6646112, DOI: 10.1097/ana.0000000000000578.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionGlobal longitudinal strainTraumatic brain injuryAge/sex-matched controlsSex-matched controlsModerate-severe traumatic brain injurySystolic dysfunctionCohort studyBrain injuryMean global longitudinal strainProspective observational cohort studyObservational cohort studyProspective cohort studySubclinical myocardial dysfunctionVentricular ejection fractionSpeckle trackingSpeckle tracking analysisFirst dayMid-ventricular segmentsModerate-severe TBI patientsSystolic functionTransthoracic echocardiographyEjection fractionMyocardial dysfunctionTBI patients
2017
Assessment of cardiac allograft systolic function by global longitudinal strain: From donor to recipient
DeVore AD, Alenezi F, Krishnamoorthy A, Ersboll M, Samsky MD, Schulte PJ, Patel CB, Rogers JG, Milano CA, Velazquez EJ, Khouri MG. Assessment of cardiac allograft systolic function by global longitudinal strain: From donor to recipient. Clinical Transplantation 2017, 31: e12961. PMID: 28294407, DOI: 10.1111/ctr.12961.Peer-Reviewed Original ResearchConceptsLV global longitudinal strainLeft ventricular ejection fractionGlobal longitudinal strainMedian left ventricular ejection fractionSystolic functionLongitudinal strainLV systolic dysfunctionMyocardial systolic performancePost-transplant outcomesLV systolic functionVentricular ejection fractionDonor-recipient pairsMyocardial deformation analysisAllograft dysfunctionCardiac allograftsCause hospitalizationSystolic dysfunctionPretransplant levelsEjection fractionSystolic performanceCorresponding recipientsClinical implicationsRecipientsEchocardiogramFurther studies
2010
Longitudinal and Circumferential Strain Rate, Left Ventricular Remodeling, and Prognosis After Myocardial Infarction
Hung CL, Verma A, Uno H, Shin SH, Bourgoun M, Hassanein AH, McMurray JJ, Velazquez EJ, Kober L, Pfeffer MA, Solomon SD, Investigators V. Longitudinal and Circumferential Strain Rate, Left Ventricular Remodeling, and Prognosis After Myocardial Infarction. Journal Of The American College Of Cardiology 2010, 56: 1812-1822. PMID: 21087709, DOI: 10.1016/j.jacc.2010.06.044.Peer-Reviewed Original ResearchConceptsCircumferential SRMyocardial infarctionHeart failureLongitudinal SRHigh-risk myocardial infarctionVALIANT Echo studyLong-term outcomesMultivariable logistic regressionStandard echocardiographic measuresClinical prognostic valueVentricular contractile performanceCox proportional hazardsParasternal short-axis viewCircumferential strain rateSpeckle-tracking softwareShort-axis viewHospital stayLV dysfunctionSystolic functionEchocardiographic measuresIndependent predictorsClinical outcomesVentricular enlargementPrognostic valueSystolic SR
2007
The Relationship Between Renal Function and Cardiac Structure, Function, and Prognosis After Myocardial Infarction The VALIANT Echo Study
Verma A, Anavekar NS, Meris A, Thune JJ, Arnold JM, Ghali JK, Velazquez EJ, McMurray JJ, Pfeffer MA, Solomon SD. The Relationship Between Renal Function and Cardiac Structure, Function, and Prognosis After Myocardial Infarction The VALIANT Echo Study. Journal Of The American College Of Cardiology 2007, 50: 1238-1245. PMID: 17888840, DOI: 10.1016/j.jacc.2007.06.018.Peer-Reviewed Original ResearchConceptsLeft ventricular mass indexRenal impairmentHeart failureMyocardial infarctionRenal functionCardiac structureReduced eGFRSystolic functionLA volumeSmaller LVHigher left ventricular mass indexLarger left atrial volumeInfarct segment lengthMitral deceleration timeVALIANT Echo studyMultivariable Cox regressionAdverse cardiovascular outcomesLeft ventricular dysfunctionNormal renal functionOutcome of deathRight ventricular functionVentricular mass indexGlomerular filtration rateAdditional prognostic informationLarger LA volumes
2006
Comparison of Regional Versus Global Assessment of Left Ventricular Function in Patients with Left Ventricular Dysfunction, Heart Failure, or Both After Myocardial Infarction: The Valsartan in Acute Myocardial Infarction Echocardiographic Study
Thune JJ, Køber L, Pfeffer MA, Skali H, Anavekar NS, Bourgoun M, Ghali JK, Arnold JM, Velazquez EJ, Solomon SD. Comparison of Regional Versus Global Assessment of Left Ventricular Function in Patients with Left Ventricular Dysfunction, Heart Failure, or Both After Myocardial Infarction: The Valsartan in Acute Myocardial Infarction Echocardiographic Study. Journal Of The American Society Of Echocardiography 2006, 19: 1462-1465. PMID: 17138030, DOI: 10.1016/j.echo.2006.05.028.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntihypertensive AgentsComorbidityEchocardiographyFemaleHeart FailureHumansInternationalityMaleMiddle AgedMyocardial InfarctionPrevalencePrognosisReproducibility of ResultsRisk AssessmentRisk FactorsSensitivity and SpecificityStroke VolumeTetrazolesValineValsartanVentricular Dysfunction, LeftConceptsWall motion indexMyocardial infarctionHeart failureLV dysfunctionEjection fractionIndependent predictorsGlobal assessmentLeft ventricular dysfunctionLV systolic functionVentricular ejection fractionAdditional prognostic informationLeft ventricular functionAcute myocardial infarctionBiplane Simpson's ruleWall motion assessmentVentricular dysfunctionSystolic functionEchocardiographic studyVentricular functionMultivariable analysisPrognostic valueAdverse outcomesPrognostic informationLVEFRegional dysfunctionAssociation of QRS duration and outcomes after myocardial infarction: the VALIANT trial
Yerra L, Anavekar N, Skali H, Zelenkofske S, Velazquez E, McMurray J, Pfeffer M, Solomon SD. Association of QRS duration and outcomes after myocardial infarction: the VALIANT trial. Heart Rhythm 2006, 3: 313-316. PMID: 16500304, DOI: 10.1016/j.hrthm.2005.11.024.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsCohort StudiesElectrocardiographyFemaleFollow-Up StudiesHeart VentriclesHumansMaleMiddle AgedMyocardial InfarctionPrognosisStroke VolumeSurvival RateTetrazolesTreatment OutcomeValineValsartanVentricular Dysfunction, LeftConceptsQRS durationSudden deathCV deathAdverse outcomesMyocardial infarctionPost-myocardial infarction settingUnivariate relative riskLeft ventricular dysfunctionHeart failure patientsSymptoms of HFAcute myocardial infarctionDevelopment of HFEnd-systolic volumeLarger ventricular volumesQRS duration prolongationRecurrent MICardiovascular deathInitial electrocardiogramVentricular dysfunctionAcute MIFailure patientsSystolic functionEjection fractionIndependent predictorsClinical outcomes
2005
Sudden Death in Patients with Myocardial Infarction and Left Ventricular Dysfunction, Heart Failure, or Both
Solomon SD, Zelenkofske S, McMurray JJ, Finn PV, Velazquez E, Ertl G, Harsanyi A, Rouleau JL, Maggioni A, Kober L, White H, Van de Werf F, Pieper K, Califf RM, Pfeffer MA. Sudden Death in Patients with Myocardial Infarction and Left Ventricular Dysfunction, Heart Failure, or Both. New England Journal Of Medicine 2005, 352: 2581-2588. PMID: 15972864, DOI: 10.1056/nejmoa043938.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionVentricular ejection fractionLeft ventricular dysfunctionMyocardial infarctionCardiac arrestSudden deathVentricular dysfunctionEjection fractionHeart failureLeft ventricular systolic functionHigh-risk patientsVentricular systolic functionSudden unexpected deathAcute myocardial infarctionCardiac causesHospital dischargeSystolic functionPercent confidence intervalsUnexpected deathHigh riskInfarctionPatientsResuscitationDysfunctionDeath