2014
Surgical Revascularization Is Associated With Maximal Survival in Patients With Ischemic Mitral Regurgitation
Castleberry AW, Williams JB, Daneshmand MA, Honeycutt E, Shaw LK, Samad Z, Lopes RD, Alexander JH, Mathew JP, Velazquez EJ, Milano CA, Smith PK. Surgical Revascularization Is Associated With Maximal Survival in Patients With Ischemic Mitral Regurgitation. Circulation 2014, 129: 2547-2556. PMID: 24744275, PMCID: PMC4142433, DOI: 10.1161/circulationaha.113.005223.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery BypassDatabases, BibliographicFemaleFollow-Up StudiesHeart Valve Prosthesis ImplantationHumansKaplan-Meier EstimateMaleMiddle AgedMitral ValveMitral Valve InsufficiencyMyocardial IschemiaMyocardial RevascularizationPercutaneous Coronary InterventionProportional Hazards ModelsRetrospective StudiesRisk FactorsSeverity of Illness IndexStentsConceptsIschemic mitral regurgitationPercutaneous coronary interventionMitral valve repairSignificant coronary artery diseaseSevere ischemic mitral regurgitationCoronary artery diseaseMitral regurgitationCoronary interventionValve repairMedical treatmentArtery diseaseTreatment strategiesLower mortalityMultivariable Cox proportional hazards analysisCox proportional hazards analysisCoronary artery bypassMitral valve surgeryKaplan-Meier methodProportional hazards analysisMitral regurgitation severitySurgical revascularizationArtery bypassValve surgeryOptimal treatmentCABG
2006
Predicting significant coronary artery disease in patients with left ventricular dysfunction
Whellan DJ, Tuttle RH, Velazquez EJ, Shaw LK, Jollis JG, Ellis W, O'Connor CM, Califf RM, Borges-Neto S. Predicting significant coronary artery disease in patients with left ventricular dysfunction. American Heart Journal 2006, 152: 340-347. PMID: 16875920, DOI: 10.1016/j.ahj.2005.12.001.Peer-Reviewed Original ResearchConceptsSignificant coronary artery diseaseCoronary artery diseaseSegmental wall motion abnormalitiesLeft ventricular dysfunctionWall motion abnormalitiesEjection functionCardiac catheterizationVentricular dysfunctionArtery diseaseMedian ageMotion abnormalitiesLikelihood of CADAccurate baseline assessmentPatients' median ageMajor epicardial vesselsDiagnostic cardiac catheterizationNumber of patientsUnnecessary invasive proceduresStepwise logistic regressionClinical characteristicsEchocardiographic parametersPrevalent comorbiditiesDuke DatabankHeart failureDiabetes mellitus
2005
Outcomes by Race and Etiology of Patients With Left Ventricular Systolic Dysfunction
Thomas KL, East MA, Velazquez EJ, Tuttle RH, Shaw LK, O’Connor C, Peterson ED. Outcomes by Race and Etiology of Patients With Left Ventricular Systolic Dysfunction. The American Journal Of Cardiology 2005, 96: 956-963. PMID: 16188524, DOI: 10.1016/j.amjcard.2005.07.002.Peer-Reviewed Original ResearchConceptsProportional hazards regression modelsLV systolic dysfunctionVentricular systolic dysfunctionSystolic dysfunctionNonischemic etiologyHeart failureAdjusted Cox proportional hazards regression modelNew York Heart Association class IICox proportional hazards regression modelRacial differencesIschemic LV systolic dysfunctionSignificant coronary artery diseaseLong-term mortality riskWorse long-term outcomesNonischemic LV dysfunctionOutcomes of patientsSystolic heart failureEtiology of patientsLV ejection fractionCoronary artery diseaseLong-term outcomesHazards regression modelsLV dysfunctionWorse survivalArtery disease
2004
Clinical characteristics and referral pattern of patients with left ventricular dysfunction and significant coronary artery disease undergoing radionuclide imaging
Bourque JM, Velazquez EJ, Borges-Neto S, Shaw LK, Whellan DJ, O'Connor C. Clinical characteristics and referral pattern of patients with left ventricular dysfunction and significant coronary artery disease undergoing radionuclide imaging. Journal Of Nuclear Cardiology 2004, 11: 118-125. PMID: 15052242, DOI: 10.1016/j.nuclcard.2003.09.005.Peer-Reviewed Original ResearchConceptsSignificant coronary artery diseaseCoronary artery diseaseLeft ventricular dysfunctionReferral patternsLV dysfunctionVentricular dysfunctionArtery diseaseMyocardial infarctionObservational studyMyocardial perfusion imaging resultsCharlson Comorbidity IndexHeart failure symptomsCongestive heart failureLogistic regression modelingNuclear perfusionCohort patientsComorbidity indexPrior revascularizationBaseline characteristicsCatheterization resultsClinical characteristicsCardiac revascularizationEjection fractionHeart failurePerfusion testing
2003
Radionuclide viability testing: should it affect treatment strategy in patients with cardiomyopathy and significant coronary artery disease?
Bourque JM, Velazquez EJ, Borges-Neto S, Shaw LK, Whellan DJ, O’Connor C. Radionuclide viability testing: should it affect treatment strategy in patients with cardiomyopathy and significant coronary artery disease? American Heart Journal 2003, 145: 758-767. PMID: 12766731, DOI: 10.1016/s0002-8703(02)94818-0.Peer-Reviewed Original ResearchMeSH KeywordsCoronary DiseaseFemaleFluorodeoxyglucose F18Heart FailureHumansMaleMyocardial RevascularizationProspective StudiesRadiopharmaceuticalsRetrospective StudiesSurvival RateThallium RadioisotopesTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, LeftConceptsSignificant coronary artery diseaseCoronary artery diseaseLong-term mortalityArtery diseaseSurvival rateHeart failureTreatment strategiesImpaired left ventricular functionLong-term mortality ratesIschemic heart failureLeft ventricular functionIntermediate survival ratesNuclear imaging studiesLack of randomizationLower survival rateEjection fractionVentricular functionViable myocardiumReferral biasStudy protocolTreatment allocationLarge cohortPrognostic studiesMortality ratePatients