2012
Mechanical dyssynchrony evaluated by tissue Doppler cross-correlation analysis is associated with long-term survival in patients after cardiac resynchronization therapy
Risum N, Williams ES, Khouri MG, Jackson KP, Olsen NT, Jons C, Storm KS, Velazquez EJ, Kisslo J, Bruun NE, Sogaard P. Mechanical dyssynchrony evaluated by tissue Doppler cross-correlation analysis is associated with long-term survival in patients after cardiac resynchronization therapy. European Heart Journal 2012, 34: 48-56. PMID: 22390911, DOI: 10.1093/eurheartj/ehs035.Peer-Reviewed Original ResearchMeSH KeywordsAgedArrhythmias, CardiacCardiac Resynchronization TherapyCardiac Resynchronization Therapy DevicesCross-Sectional StudiesDefibrillators, ImplantableFeasibility StudiesFemaleHumansMaleMiddle AgedRetrospective StudiesStroke VolumeTreatment OutcomeUltrasonography, Doppler, ColorVentricular Dysfunction, LeftConceptsCardiac resynchronization therapyLong-term survivalMechanical dyssynchronyYu indexResynchronization therapyCox proportional hazards regressionLeft bundle branch blockProportional hazards regressionTissue Doppler imagingBundle branch blockPre-implant assessmentActivation delayVentricular assist deviceCardiac transplantationCause mortalityCRT candidatesImproved survivalHazards regressionPoor prognosisSubgroup analysisBranch blockWall delayPoor survivalDyssynchronyDoppler imaging
2010
Prevalence and predictors of mechanical dyssynchrony as defined by phase analysis in patients with left ventricular dysfunction undergoing gated SPECT myocardial perfusion imaging
Samad Z, Atchley AE, Trimble MA, Sun JL, Shaw LK, Pagnanelli R, Chen J, Garcia EV, Iskandrian AE, Velazquez EJ, Borges-Neto S. Prevalence and predictors of mechanical dyssynchrony as defined by phase analysis in patients with left ventricular dysfunction undergoing gated SPECT myocardial perfusion imaging. Journal Of Nuclear Cardiology 2010, 18: 24-30. PMID: 21082299, PMCID: PMC3077282, DOI: 10.1007/s12350-010-9310-7.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlgorithmsCardiac-Gated Single-Photon Emission Computer-Assisted TomographyFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedIncidenceMaleMyocardial Perfusion ImagingNorth CarolinaPrevalenceReproducibility of ResultsRisk AssessmentRisk FactorsSensitivity and SpecificityVentricular Dysfunction, LeftConceptsLeft ventricular dysfunctionMechanical dyssynchronyVentricular dysfunctionIndependent predictorsBlack raceQRS durationPhase SDGated SPECT myocardial perfusionLeft ventricular ejection fractionTomography myocardial perfusion imagingStress scoresVentricular ejection fractionIschemic heart diseasePopulation of patientsMeasures of dyssynchronySPECT myocardial perfusionMyocardial perfusion imagingSingle photon emissionSignificant dyssynchronyEjection fractionEntire cohortUnivariate predictorsClinical variablesHeart diseaseMale genderMechanical Dyssynchrony After Myocardial Infarction in Patients With Left Ventricular Dysfunction, Heart Failure, or Both
Shin SH, Hung CL, Uno H, Hassanein AH, Verma A, Bourgoun M, Køber L, Ghali JK, Velazquez EJ, Califf RM, Pfeffer MA, Solomon SD. Mechanical Dyssynchrony After Myocardial Infarction in Patients With Left Ventricular Dysfunction, Heart Failure, or Both. Circulation 2010, 121: 1096-1103. PMID: 20176989, DOI: 10.1161/circulationaha.109.863795.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnalog-Digital ConversionAngiotensin II Type 1 Receptor BlockersDeathDisease ProgressionFemaleFollow-Up StudiesHeart FailureHumansMaleMiddle AgedMotionMyocardial ContractionMyocardial InfarctionPrognosisProportional Hazards ModelsStress, MechanicalTetrazolesUltrasonographyValineValsartanVentricular Dysfunction, LeftVideo RecordingConceptsSD of timeLeft ventricular dysfunctionHeart failureMyocardial infarctionMechanical dyssynchronyVentricular dysfunctionIndependent predictorsPost-myocardial infarction prognosisPeak velocityAdverse cardiovascular outcomesMultivariate Cox modelRisk of deathLeft ventricular segmentsMeasures of dyssynchronyVelocity vector imagingCardiovascular outcomesEchocardiographic variablesVentricular synchronyVentricular dyssynchronyClinical outcomesEchocardiography studyRisk factorsContractile patternsVentricular segmentsCox model
2009
Use of phase analysis of gated SPECT perfusion imaging to quantify dyssynchrony in patients with mild-to-moderate left ventricular dysfunction
Atchley AE, Trimble MA, Samad Z, Shaw LK, Pagnanelli R, Chen J, Garcia EV, Iskandrian AE, Velazquez EJ, Borges-Neto S. Use of phase analysis of gated SPECT perfusion imaging to quantify dyssynchrony in patients with mild-to-moderate left ventricular dysfunction. Journal Of Nuclear Cardiology 2009, 16: 888-894. PMID: 19690935, PMCID: PMC3048054, DOI: 10.1007/s12350-009-9136-3.Peer-Reviewed Original ResearchConceptsModerate LV dysfunctionSevere LV dysfunctionLV dysfunctionMechanical dyssynchronyQRS durationNormal controlsGated SPECTModerate left ventricular dysfunctionNYHA class IIIPrevalence of dyssynchronyLeft ventricular dysfunctionCohort of patientsMajority of patientsLV mechanical dyssynchronyGated SPECT imagingCurrent selection criteriaLess dyssynchronyLVEF 35More dyssynchronyVentricular dysfunctionPatient selectionDyssynchronyPatientsSPECT perfusionDysfunction
2008
Left Ventricular Mechanical Dyssynchrony as Assessed by Phase Analysis of ECG‐Gated SPECT Myocardial Perfusion Imaging
Chen J, Garcia EV, Lerakis S, Henneman MM, Bax JJ, Trimble MA, Borges‐Neto S, Velazquez EJ, Iskandrian AE. Left Ventricular Mechanical Dyssynchrony as Assessed by Phase Analysis of ECG‐Gated SPECT Myocardial Perfusion Imaging. Echocardiography 2008, 25: 1186-1194. PMID: 18986406, DOI: 10.1111/j.1540-8175.2008.00782.x.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyMyocardial perfusion imagingTissue Doppler imagingLV dyssynchronyPerfusion imagingTomography myocardial perfusion imagingSPECT myocardial perfusion imagingElectrocardiography-gated single-photon emissionSevere heart failureVentricular mechanical dyssynchronySingle photon emissionHeart failureMechanical dyssynchronyResynchronization therapyClinical evaluationDyssynchronyLeft ventricleDoppler imagingPatientsRegional wallMechanical contractionPhoton emissionCardiac cycleImportant predictorFourier harmonic functionsEvaluation of mechanical dyssynchrony and myocardial perfusion using phase analysis of gated SPECT imaging in patients with left ventricular dysfunction
Trimble MA, Borges-Neto S, Honeycutt EF, Shaw LK, Pagnanelli R, Chen J, Iskandrian AE, Garcia EV, Velazquez EJ. Evaluation of mechanical dyssynchrony and myocardial perfusion using phase analysis of gated SPECT imaging in patients with left ventricular dysfunction. Journal Of Nuclear Cardiology 2008, 15: 663-670. PMID: 18761269, PMCID: PMC3048059, DOI: 10.1016/j.nuclcard.2008.06.007.Peer-Reviewed Original ResearchConceptsLeft ventricular dysfunctionMechanical dyssynchronyQRS durationPhase SDHF patientsVentricular dysfunctionPerfusion abnormalitiesMyocardial perfusionGated SPECT myocardial perfusion imagingLV phase distributionPhase analysis indicesSPECT myocardial perfusion imagingHeart failure patientsCardiac resynchronization therapyMeasures of dyssynchronyMyocardial perfusion imagingSingle photon emissionLV dysfunctionFailure patientsResynchronization therapyEjection fractionElectrical dyssynchronyMyocardial functionDyssynchronyMyocardial thickening24.09: Differences in electrical and mechanical dyssynchrony as quantified by phase analysis of gated SPECT imaging in patients with mild to moderate left ventricular dysfunction
Trimble M, Atchley A, Samad Z, Sun J, Shaw L, Pagnanelli R, Chen J, Garcia E, Iskandrian A, Borges-Neto S, Velazquez E. 24.09: Differences in electrical and mechanical dyssynchrony as quantified by phase analysis of gated SPECT imaging in patients with mild to moderate left ventricular dysfunction. Journal Of Nuclear Cardiology 2008, 15: s27-s28. DOI: 10.1016/j.nuclcard.2008.06.151.Peer-Reviewed Original ResearchEmerging Role of Myocardial Perfusion Imaging to Evaluate Patients for Cardiac Resynchronization Therapy††Conflicts of interest: Dr. Garcia has an ownership interest in and serves as a consultant and advisory board member for Syntermed, Inc., Atlanta, Georgia. Dr. Garcia also receives royalties from the sale of clinical software that was used as part of this research. Dr. Borges-Neto and Dr. Trimble have received research support from the Duke-Medtronic Strategic Alliance, which funded some of the studies reviewed in this report.
Trimble MA, Borges-Neto S, Velazquez EJ, Chen J, Shaw LK, Pagnanelli R, Garcia EV, Iskandrian AE. Emerging Role of Myocardial Perfusion Imaging to Evaluate Patients for Cardiac Resynchronization Therapy††Conflicts of interest: Dr. Garcia has an ownership interest in and serves as a consultant and advisory board member for Syntermed, Inc., Atlanta, Georgia. Dr. Garcia also receives royalties from the sale of clinical software that was used as part of this research. Dr. Borges-Neto and Dr. Trimble have received research support from the Duke-Medtronic Strategic Alliance, which funded some of the studies reviewed in this report. The American Journal Of Cardiology 2008, 102: 211-217. PMID: 18602524, DOI: 10.1016/j.amjcard.2008.03.043.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyMechanical dyssynchronyElectrical dyssynchronyMyocardial perfusionSignificant heart failure symptomsTomographic myocardial perfusion imagingLV functional improvementHeart failure symptomsLV systolic dysfunctionSevere LV dysfunctionSelection of patientsManagement of patientsLV mechanical dyssynchronyLeft ventricular dyssynchronyMyocardial perfusion imagingCurrent selection criteriaLV dysfunctionSystolic dysfunctionEchocardiographic measuresResynchronization therapyVentricular dyssynchronyCardiac resynchronizationClinical statusLV remodelingFailure symptomsMeasuring left ventricular mechanical dyssynchrony from ECG-gated SPECT myocardial perfusion imaging.
Chen J, Garcia EV, Henneman MM, Bax JJ, Boogers MJ, Trimble MA, Borges-Neto S, Velazquez EJ, Iskandrian AE. Measuring left ventricular mechanical dyssynchrony from ECG-gated SPECT myocardial perfusion imaging. Minerva Cardioangiologica 2008, 56: 227-35. PMID: 18319701.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyTissue Doppler imagingMyocardial perfusion imagingLV dyssynchronyECG-gated SPECT myocardial perfusion imagingPerfusion imagingCardiac resynchronization therapy (CRT) trialsMyocardial strain-rate imagingTomography myocardial perfusion imagingClinical validationAvailable echocardiographic techniquesSPECT myocardial perfusion imagingSevere heart failureVentricular mechanical dyssynchronyPredictors of responseRoutine clinical practiceStrain rate imagingSingle photon emissionEntire left ventricleHeart failureMechanical dyssynchronyResynchronization therapyEchocardiographic techniquesDyssynchronyClinical practice