2018
A meta‐analysis of MitraClip combined with medical therapy vs. medical therapy alone for treatment of mitral regurgitation in heart failure patients
Giannini C, D'ascenzo F, Fiorelli F, Spontoni P, Swaans MJ, Velazquez EJ, Armeni P, Adamo M, De Carlo M, Petronio AS. A meta‐analysis of MitraClip combined with medical therapy vs. medical therapy alone for treatment of mitral regurgitation in heart failure patients. ESC Heart Failure 2018, 5: 1150-1158. PMID: 30191666, PMCID: PMC6300824, DOI: 10.1002/ehf2.12339.Peer-Reviewed Original ResearchConceptsFunctional mitral regurgitationMedical therapyMitral regurgitationSurvival benefitConservative treatmentPercutaneous mitral valve repairEffect of MitraClipRobust survival benefitSignificant survival benefitCardiac resynchronization therapyEligible observational studiesHeart failure patientsVentricular ejection fractionMitral valve repairPatient-level analysisComprehensive literature searchStudy-level analysisConservative therapyIschemic etiologyPrimary endpointFailure patientsMultivariate adjustmentEjection fractionResynchronization therapySurvival outcomesImpaired Recovery of Left Ventricular Function in Patients With Cardiomyopathy and Left Bundle Branch Block
Sze E, Samad Z, Dunning A, Campbell KB, Loring Z, Atwater BD, Chiswell K, Kisslo JA, Velazquez EJ, Daubert JP. Impaired Recovery of Left Ventricular Function in Patients With Cardiomyopathy and Left Bundle Branch Block. Journal Of The American College Of Cardiology 2018, 71: 306-317. PMID: 29348023, PMCID: PMC8352572, DOI: 10.1016/j.jacc.2017.11.020.Peer-Reviewed Original ResearchConceptsGuideline-directed medical therapyLeft bundle branch blockCardiac resynchronization therapyWide QRS durationBundle branch blockQRS durationLVEF improvementQRS morphologyReduced LVEFBranch blockLeft ventricular ejection fraction improvementVentricular ejection fraction improvementEjection fraction improvementMean LVEF improvementNarrow QRS durationSevere valve diseaseFirst-line therapyHeart failure hospitalizationLeft ventricular functionVentricular assist deviceBaseline electrocardiographyFailure hospitalizationCombined endpointSignificant comorbiditiesResynchronization therapy
2012
Mechanical dyssynchrony evaluated by tissue Doppler cross-correlation analysis is associated with long-term survival in patients after cardiac resynchronization therapy
Risum N, Williams ES, Khouri MG, Jackson KP, Olsen NT, Jons C, Storm KS, Velazquez EJ, Kisslo J, Bruun NE, Sogaard P. Mechanical dyssynchrony evaluated by tissue Doppler cross-correlation analysis is associated with long-term survival in patients after cardiac resynchronization therapy. European Heart Journal 2012, 34: 48-56. PMID: 22390911, DOI: 10.1093/eurheartj/ehs035.Peer-Reviewed Original ResearchMeSH KeywordsAgedArrhythmias, CardiacCardiac Resynchronization TherapyCardiac Resynchronization Therapy DevicesCross-Sectional StudiesDefibrillators, ImplantableFeasibility StudiesFemaleHumansMaleMiddle AgedRetrospective StudiesStroke VolumeTreatment OutcomeUltrasonography, Doppler, ColorVentricular Dysfunction, LeftConceptsCardiac resynchronization therapyLong-term survivalMechanical dyssynchronyYu indexResynchronization therapyCox proportional hazards regressionLeft bundle branch blockProportional hazards regressionTissue Doppler imagingBundle branch blockPre-implant assessmentActivation delayVentricular assist deviceCardiac transplantationCause mortalityCRT candidatesImproved survivalHazards regressionPoor prognosisSubgroup analysisBranch blockWall delayPoor survivalDyssynchronyDoppler imaging
2008
Left Ventricular Mechanical Dyssynchrony as Assessed by Phase Analysis of ECG‐Gated SPECT Myocardial Perfusion Imaging
Chen J, Garcia EV, Lerakis S, Henneman MM, Bax JJ, Trimble MA, Borges‐Neto S, Velazquez EJ, Iskandrian AE. Left Ventricular Mechanical Dyssynchrony as Assessed by Phase Analysis of ECG‐Gated SPECT Myocardial Perfusion Imaging. Echocardiography 2008, 25: 1186-1194. PMID: 18986406, DOI: 10.1111/j.1540-8175.2008.00782.x.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyMyocardial perfusion imagingTissue Doppler imagingLV dyssynchronyPerfusion imagingTomography myocardial perfusion imagingSPECT myocardial perfusion imagingElectrocardiography-gated single-photon emissionSevere heart failureVentricular mechanical dyssynchronySingle photon emissionHeart failureMechanical dyssynchronyResynchronization therapyClinical evaluationDyssynchronyLeft ventricleDoppler imagingPatientsRegional wallMechanical contractionPhoton emissionCardiac cycleImportant predictorFourier harmonic functionsEvaluation of mechanical dyssynchrony and myocardial perfusion using phase analysis of gated SPECT imaging in patients with left ventricular dysfunction
Trimble MA, Borges-Neto S, Honeycutt EF, Shaw LK, Pagnanelli R, Chen J, Iskandrian AE, Garcia EV, Velazquez EJ. Evaluation of mechanical dyssynchrony and myocardial perfusion using phase analysis of gated SPECT imaging in patients with left ventricular dysfunction. Journal Of Nuclear Cardiology 2008, 15: 663-670. PMID: 18761269, PMCID: PMC3048059, DOI: 10.1016/j.nuclcard.2008.06.007.Peer-Reviewed Original ResearchConceptsLeft ventricular dysfunctionMechanical dyssynchronyQRS durationPhase SDHF patientsVentricular dysfunctionPerfusion abnormalitiesMyocardial perfusionGated SPECT myocardial perfusion imagingLV phase distributionPhase analysis indicesSPECT myocardial perfusion imagingHeart failure patientsCardiac resynchronization therapyMeasures of dyssynchronyMyocardial perfusion imagingSingle photon emissionLV dysfunctionFailure patientsResynchronization therapyEjection fractionElectrical dyssynchronyMyocardial functionDyssynchronyMyocardial thickeningEmerging Role of Myocardial Perfusion Imaging to Evaluate Patients for Cardiac Resynchronization Therapy††Conflicts of interest: Dr. Garcia has an ownership interest in and serves as a consultant and advisory board member for Syntermed, Inc., Atlanta, Georgia. Dr. Garcia also receives royalties from the sale of clinical software that was used as part of this research. Dr. Borges-Neto and Dr. Trimble have received research support from the Duke-Medtronic Strategic Alliance, which funded some of the studies reviewed in this report.
Trimble MA, Borges-Neto S, Velazquez EJ, Chen J, Shaw LK, Pagnanelli R, Garcia EV, Iskandrian AE. Emerging Role of Myocardial Perfusion Imaging to Evaluate Patients for Cardiac Resynchronization Therapy††Conflicts of interest: Dr. Garcia has an ownership interest in and serves as a consultant and advisory board member for Syntermed, Inc., Atlanta, Georgia. Dr. Garcia also receives royalties from the sale of clinical software that was used as part of this research. Dr. Borges-Neto and Dr. Trimble have received research support from the Duke-Medtronic Strategic Alliance, which funded some of the studies reviewed in this report. The American Journal Of Cardiology 2008, 102: 211-217. PMID: 18602524, DOI: 10.1016/j.amjcard.2008.03.043.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyMechanical dyssynchronyElectrical dyssynchronyMyocardial perfusionSignificant heart failure symptomsTomographic myocardial perfusion imagingLV functional improvementHeart failure symptomsLV systolic dysfunctionSevere LV dysfunctionSelection of patientsManagement of patientsLV mechanical dyssynchronyLeft ventricular dyssynchronyMyocardial perfusion imagingCurrent selection criteriaLV dysfunctionSystolic dysfunctionEchocardiographic measuresResynchronization therapyVentricular dyssynchronyCardiac resynchronizationClinical statusLV remodelingFailure symptomsMeasuring left ventricular mechanical dyssynchrony from ECG-gated SPECT myocardial perfusion imaging.
Chen J, Garcia EV, Henneman MM, Bax JJ, Boogers MJ, Trimble MA, Borges-Neto S, Velazquez EJ, Iskandrian AE. Measuring left ventricular mechanical dyssynchrony from ECG-gated SPECT myocardial perfusion imaging. Minerva Cardioangiologica 2008, 56: 227-35. PMID: 18319701.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyTissue Doppler imagingMyocardial perfusion imagingLV dyssynchronyECG-gated SPECT myocardial perfusion imagingPerfusion imagingCardiac resynchronization therapy (CRT) trialsMyocardial strain-rate imagingTomography myocardial perfusion imagingClinical validationAvailable echocardiographic techniquesSPECT myocardial perfusion imagingSevere heart failureVentricular mechanical dyssynchronyPredictors of responseRoutine clinical practiceStrain rate imagingSingle photon emissionEntire left ventricleHeart failureMechanical dyssynchronyResynchronization therapyEchocardiographic techniquesDyssynchronyClinical practice