2012
Polycystic ovary syndrome in adolescence: impaired glucose tolerance occurs across the spectrum of BMI
Flannery CA, Rackow B, Cong X, Duran E, Selen DJ, Burgert TS. Polycystic ovary syndrome in adolescence: impaired glucose tolerance occurs across the spectrum of BMI. Pediatric Diabetes 2012, 14: 42-49. PMID: 22925367, PMCID: PMC4864958, DOI: 10.1111/j.1399-5448.2012.00902.x.Peer-Reviewed Original ResearchConceptsOral glucose tolerance testingPolycystic ovary syndromeAbnormal glucose metabolismGlucose metabolismOB cohortOvary syndromeGlucose toleranceAndrogen Excess Society criteriaHomeostatic model assessmentPresence of obesityGlucose tolerance testingC-reactive proteinType 2 diabetesNon-obese adolescentsHigh-density lipoproteinInsulin levelsInsulin resistanceSubgroup analysisChronic conditionsMetabolic manifestationsReproductive yearsSociety criteriaLipid profileTolerance testingTestosterone levels
2011
Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals
Rabøl R, Petersen KF, Dufour S, Flannery C, Shulman GI. Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 13705-13709. PMID: 21808028, PMCID: PMC3158147, DOI: 10.1073/pnas.1110105108.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseHepatic de novo lipogenesisMuscle insulin resistanceInsulin-resistant individualsDe novo lipogenesisSkeletal muscle insulin resistanceCarbohydrate-rich mealInsulin resistanceHepatic triglyceride synthesisNovo lipogenesisAtherogenic dyslipidemiaMetabolic syndromeRandomized cross-over trialTriglyceride synthesisFatty liver diseasePostprandial plasma glucoseMuscle insulin responsivenessCross-over trialEarly therapeutic targetType 2 diabetesMuscle glycogen synthesisBody energy storageLiver diseasePlasma glucoseSingle bout