2020
Dendritic Spine Dynamics after Peripheral Nerve Injury: An Intravital Structural Study
Benson CA, Fenrich KK, Olson KL, Patwa S, Bangalore L, Waxman SG, Tan AM. Dendritic Spine Dynamics after Peripheral Nerve Injury: An Intravital Structural Study. Journal Of Neuroscience 2020, 40: 4297-4308. PMID: 32371602, PMCID: PMC7252482, DOI: 10.1523/jneurosci.2858-19.2020.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDendritic SpinesMaleMiceMice, Inbred C57BLMicroscopy, Fluorescence, MultiphotonPeripheral Nerve InjuriesSpinal Cord Dorsal HornConceptsDendritic spine dynamicsInjury-induced painPeripheral nerve injuryNeuropathic painDorsal hornSpine dynamicsNerve injuryPeripheral nerve injury-induced painNerve injury-induced painSuperficial dorsal horn neuronsSpinal cord dorsal hornDorsal horn neuronsSuperficial dorsal hornMechanisms of painDendritic spine dysgenesisContext of injuryPostmortem tissue analysisSame dendritic branchRepeat imagingMale miceMedical conditionsEffective treatmentPainSpine dysgenesisDendritic spines
2011
Rac1-regulated dendritic spine remodeling contributes to neuropathic pain after peripheral nerve injury
Tan AM, Chang YW, Zhao P, Hains BC, Waxman SG. Rac1-regulated dendritic spine remodeling contributes to neuropathic pain after peripheral nerve injury. Experimental Neurology 2011, 232: 222-233. PMID: 21963650, DOI: 10.1016/j.expneurol.2011.08.028.Peer-Reviewed Original ResearchConceptsDorsal horn neuronsPeripheral nerve injuryChronic constriction injuryWide dynamic range dorsal horn neuronsRange dorsal horn neuronsNerve injuryNeuropathic painDendritic spinesTactile allodyniaThermal hyperalgesiaSpine morphologyInjury-induced hyperexcitabilityNoxious peripheral stimuliSpinal cord injuryMushroom-shaped spinesDendritic spine developmentDendritic spine morphologyConstriction injuryHyperexcitable responsesCCI animalsNeuronal hyperexcitabilityIpsilateral hindNociceptive thresholdSpine densityCord injury