Editing mosquito’s gene wards off malaria and halts reproduction
Scientists have looked for immune system factors that might help mosquitoes ward off pathogens such as malarial parasites and indirectly protect humans from infection. Yale researchers found one by editing a single gene, which turns out to be crucial for female reproduction.
Schechner Memorial Lecture, Hosted by Department of Dermatology, to Be Given by Valentina Greco, PhD, on Oct. 30
Valentina Greco, PhD, Carolyn Walch Slayman Professor of Genetics, will speak about "Principles of Skin Epithelial Tolerance Discovered by Live Imaging" on October 30 at 10 a.m., in the Fitkin Amphitheatre.
Yale Scientists Help Immune System Find Hidden Cancer Cells
Cancer cells are masters at avoiding detection, but a new system developed by Yale Cancer Center scientists can make them stand out from the crowd and help the immune system spot and eliminate tumors that other forms of immunotherapies might miss, the researchers report Oct. 14 in the journal Nature Immunology.
Geneticist Greco Receives a Major Government Research Award
Valentina Greco, PhD, Carolyn Walch Slayman Professor of Genetics, has been awarded the National Institutes of Health (NIH) Director’s Pioneer Award. The grant, $3.5 million over the next five years, is inspired by Greco’s pioneering research into skin stem cells, which has revealed in intricate detail the secrets to their daily and ever-changing lives.
Yale Launches Comprehensive DNA Sequencing Project, With Aim of Predicting, Preventing, and Treating Gene-related Diseases
Generations, a collaboration between Yale School of Medicine and Yale New Haven Health System, is one of the largest DNA sequencing projects of its kind in the United States.
Horwich Is Co-recipient of $3 Million Breakthrough Prize
Arthur L. Horwich, MD, Sterling Professor of Genetics and professor of pediatrics, and his colleague F. Ulrich Hartl, from the Max Planck Institute, will share a 2020 Breakthrough Prize. This prize was developed by Sergey Brin, Mark Zuckerberg, Jack Ma, and Yuri Milner, together with their families, to honor the most accomplished life scientists.
School of Medicine Rare Disease Researcher Is Also a Patient
Geneticist Monkol Lek, PhD, may study rare diseases, but the subject is far from academic for him. That’s because Lek has a rare disease, a form of muscular dystrophy that requires him to use a wheelchair at times. His real-life experience has led him to eschew pure research in favor of finding practical treatments.
Yale Researchers Find Genetic Clues to Troubling PTSD Symptom
Symptoms of post-traumatic stress disorder (PTSD) overlap with several other psychiatric disorders, but one specific symptom — repeated disturbing memories and flashbacks about a specific event — is a defining characteristic of debilitating PTSD.
Gene Plays Role in Early-Onset Heart Disease and Diabetes
When heart disease affects people under age 50, it’s considered “early onset” and experts believe there’s a genetic link. Yale investigators have found that a particular gene is common to families with multiple members who either have early-onset heart disease or are at risk for it.
New Research Shows Key Role for Proteins P300 and Brd4 in Genome Activation During Early Development
Researchers from Yale University led by Professor Antonio Giraldez have recently discovered that two proteins, P300 and Brd4, are both required and sufficient to enable the activation of genetic self-regulation in zebrafish embryos. Understanding how this genetic activation is controlled is crucial for a deeper understanding of the fundamentals of animal development.
Yale Study Identifies How Cancer Drug Inhibits DNA Repair in Cancer Cells
Yale Cancer Center researchers have found that a cancer drug thought to be of limited use possesses an unforeseen property. It is able to stop certain cancer cells from repairing their DNA in order to survive. The study suggests that combining this drug, cediranib, with other agents could potentially deliver a lethal blow in cancer that uses a specific process to create DNA repair cells.
Scientists Restore Some Functions in a Pig’s Brain Hours After Death
Circulation and cellular activity were restored in a pig’s brain four hours after its death, a finding that challenges long-held assumptions about the timing and irreversible nature of the cessation of some brain functions after death, Yale scientists report in the journal Nature.
New test could lead to personalized treatments for cystic fibrosis
Cystic fibrosis is a devastating disease caused by mutations in a specific gene, known as the CFTR gene. But not everyone with cystic fibrosis has the same symptoms or responds to drug treatments in the same way. In a new pilot study, researchers from the University of Cambridge and Yale University developed a novel, straightforward way to test multiple drugs on cells obtained from individual patients with cystic fibrosis, raising the possibility of highly personalized drug treatment.