New Insight Into the Biology of Insulin Release
In a new study, Yale researchers challenge a long-held assumption about how insulin-producing cells in the pancreas sense and respond to glucose. Their findings could lead to changes in the way that scientists approach the treatment of diabetes, the authors said.
Yale-led Study Reveals Biology of Leptin, the Hunger Hormone
In a new study, Yale researchers offer insight into leptin, a hormone that plays a key role in appetite, overeating, and obesity. Their findings advance knowledge about leptin and weight gain, and also suggest a potential strategy for developing future weight-loss treatments, they said.
Immunotherapy Delays Type 1 Diabetes in People at High Risk
A drug that targets the immune system can delay the onset of type 1 diabetes in people at high risk of developing the disease, said a Yale investigator who led the National Institutes of Health-funded Diabetes TrialNet study. The research is the first to show that the progression of type 1 diabetes can be slowed by two or more years with immunotherapy.
Finally, Another Effective Drug for Kids and Teens with Type 2 Diabetes
Type 2 diabetes is on the rise in children and teens, but treatment options for pediatric patients have remained more limited than those available to adults. In its first pediatric trial, a new drug — already used by type 2 diabetic adults — has proven effective for blood sugar control in children and teens with type 2 diabetes.
Yale Expert Testifies in Washington on the Harm Caused by Soaring Insulin Prices
On April 2, Kasia Lipska, MD, MPH, assistant professor of medicine (endocrinology), testified in Washington before the House Committee on Energy & Commerce Oversight and Investigations Subcommittee on the severe harm that high insulin prices does to patients, including her own.
Human insulin as safe and effective to treat type 2 diabetes as costlier insulin analogs
Patients with Type 2 diabetes who were treated with the newer generation of insulin analog drugs did not have substantially better outcomes than those treated with less costly human insulin, according to a study by Yale School of Medicine researchers and colleagues at Kaiser Permanente.
High rates of HIV and diabetes raise the risk of TB for South Africans
Since the 1980s, HIV has contributed to an increase in tuberculosis (TB) cases across the globe. Recently, diabetes has been found to be an important risk factor for TB. In a new study, Yale researchers investigated whether having both HIV and diabetes increases the risk of developing TB among individuals living in rural South Africa.
Dr. Gerald Shulman wins American Diabetes Association’s highest honor
Dr. Gerald I. Shulman of the Yale School of Medicine has won the 2018 Banting Medal for Scientific Achievement, the highest honor of the American Diabetes Association (ADA). Shulman will be recognized for this honor and deliver his Banting Medal Lecture, “Mechanisms of Insulin Resistance: Implications for Obesity, Lipodystrophy and Type 2 Diabetes,” at the ADA’s 78th Scientific Sessions in Orlando, Florida, June 22-26.
Leptin hormone spurs body’s shift from burning carbs to fat
To keep the human brain supplied with energy when food was scarce, mammals evolved the ability to switch from burning carbohydrates to burning fat in order to preserve skeletal muscle that would otherwise be metabolized and converted to glucose. Scientists have long believed that the transition to fat metabolism was instigated solely by a drop in insulin. But a new study has identified leptin — a hormone made by fat cells — as a key mediator in this fundamental biological process.
ASCC-ACNR Land Grant screens new "Edutainment" films
The Agriculture, Community and Natural Resources (ACNR) Land Grant division of the American Samoa Community College (ASCC) recently held a special presentation titled “See the Change You Want to Be, and Be the Change You Want to See” which included the premiere screening of two new health awareness films produced specifically for American Samoa.
Affordable housing is at crisis levels — here's how tax reform can help
The House Republican Tax bill proposes cuts to the country’s largest subsidized housing program, the mortgage interest deduction (MID). This $70 billion dollar tax expenditure largely benefits high income Americans: The larger the mortgage, the larger the deduction, for mortgages under $1 million.
Study reveals how a very low calorie diet can reverse type 2 diabetes
In a new study, a Yale-led research team uncovers how a very low calorie diet can rapidly reverse type 2 diabetes in animal models. If confirmed in people, the insight provides potential new drug targets for treating this common chronic disease, said the researchers.
Lower brain glucose levels found in people with obesity, type 2 diabetes
Glucose levels are reduced in the brains of individuals with obesity and type 2 diabetes compared to lean individuals, according to a new Yale study. The finding might explain disordered eating behavior — and even a higher risk of Alzheimer’s disease — among obese and diabetic individuals, the researchers said.
Artificial pancreas gets a trial run
Nine-year-old Summer Alba watched in rapt attention as the tour guide at the Yale Peabody Museum of Natural History animatedly outlined the profile of a bird-like dinosaur on a laminated sheet. As the guide described melanin and skin, one wonders whether Summer’s attention returned to the pod attached to her own skin—visible on her upper arm, and perhaps nearly forgotten. She was one of five children (aged nine to 11 years) and one adult participating in a five-day clinical trial for a system to manage type 1 diabetes; the pod is a discreet insulin dispenser.
Could modifying gut microbes prevent or delay type 1 diabetes?
Autoimmune diseases such as type 1 diabetes are controlled by our genes. While researchers are eager to find out what other factors could contribute to this disease, a new study published by Yale researchers provides direct evidence that environmental factors, such as microbes that inhabit our intestines, may influence the incidence of the disease.