New Research May Explain Unexpected Effects of Common Painkillers
Some NSAIDs prevent heart disease while others cause it; some NSAIDs have been linked to decreased incidence of colorectal cancer; and various NSAIDs can have a wide range of effects on asthma. Now, using cell cultures and mice, Yale researchers have uncovered a distinct mechanism by which a subset of NSAIDs reduce inflammation. And that mechanism may help explain some of these curious effects.Source: YaleNews
The Molecular Machinery That Delivers Metabolites to Mitochondria
When we eat and then digest a meal, the nutrients and other useful components in the food are broken down—or metabolized—and ultimately make their way to cells throughout the body. Hongying Shen, PhD, and her lab have identified the molecular machinery through which many of the metabolites reach inside the mitochondria in cells.
Discovering a Mysterious Estrogen’s Important Role in Pregnancy
When a woman becomes pregnant, her levels of estriol, one of the three common estrogens that are nearly undetectable before conception, skyrocket. However, scientists never knew what this hormone does or why levels of it build as they do. Now, Yale researchers have discovered that estriol plays an extremely important role in shaping the future of offspring.
How Effects on the Brain Can Produce Long COVID
COVID-19 may be primarily a respiratory illness, but its reach extends far beyond the lungs, with an impact that includes the brain. The neurologic and psychiatric complications of COVID-19 are incredibly diverse and sometimes persist long after patients recover from their initial infections.
New Yale Center Will Focus on Infection and Immunity
The center will have an ambitious goal: to produce better diagnoses, treatments, and ultimately cures for an array of diseases. It will also work toward vaccine development, based on Iwasaki’s pioneering work showing that vaccines directed toward the mucosa might provide better protection than systemic vaccination.
Portable MRIs Almost as Effective as Standard MRIs in Detecting Strokes
“This is the first systematic evidence you can detect ischemic strokes using portable, bedside devices,” said Kevin Sheth, a professor of neurology and neurosurgery at Yale School of Medicine and co-corresponding author of the study.Source: YaleNews
Colón-Ramos Awarded Germany’s Humboldt Prize
Daniel Colón-Ramos, the Dorys McConnell Duberg Professor of Neuroscience and Cell Biology at Yale, has been awarded the Humboldt Prize for his lab’s work in describing fundamental aspects of the cell biology of synapses and behavior, the Alexander von Humboldt Foundation announced April 13.Source: YaleNews
Margaret McGovern, MD, PhD, Appointed YSM Deputy Dean and CEO of Yale Medicine
McGovern will play an essential role in the development of clinical strategy for the School of Medicine at an important juncture in the relationship between YSM and Yale New Haven Health System. She will provide strategic counsel and otherwise work to realize YSM’s vision for its clinical enterprise.
How Bacteria Swim: Yale Researchers Discover New Mechanisms
How bacteria move around, survive, and cause infection in the body has long fascinated scientists, but understanding of the mechanisms involved is incomplete. Now, for the first time, with cryo-EM tomography, Yale researchers have visualized key elements of a ring structure that stabilizes the motor of the flagellum and enhances bacterial movement.
Unique Yale Master's Program Will Combine Surgery and Engineering
Orthopaedic surgery requires a close partnership among surgeons and engineers. While surgeons have the expertise in performing operations, engineers possess important technological skills in 3D planning. The new master's program will combine the two disciplines.
Revealing Communications Between Brain and Body
“This is the first time we actually know how different body signals are being represented through the vagal interoception system to the brain in a very precise and accurate manner,” says co-senior investigator Rui Chang, PhD. “We know that the brain can very precisely discriminate signals, but what is the biological reason for that discrimination?”