New Instructional Video on Optimal Femoral Access Corrects Anatomical Error
Vascular surgeons, interventional cardiologists and radiologists, and neurosurgeons perform procedures that involve femoral artery access, but techniques vary across the various specialties. Now, a group at Yale School of Medicine has created an instructional video that optimizes femoral punctures and decreases the risk of complication and bleeding. The team hopes that its work could standardize the technique for accessing the femoral artery and will lead to better patient outcomes.
Keith Choate, MD ’04, PhD ’01, Appointed Chair/Chief of Dermatology
Keith Choate, MD, PhD, will become chair of the Department of Dermatology and chief of Dermatology of Yale New Haven Hospital effective October 1, 2022. Choate will also work collaboratively with delivery network leadership to advance dermatological services across Yale New Haven Health System.
Yale Neurosurgeons Implant First Endovascular Device for Hydrocephalus in North America
A leading expert in neuroendovascular surgery, Charles Matouk, MD, and his team at Yale School of Medicine are now paving the way for better treatments for adult-onset hydrocephalus by being the first in the country to implant the eShunt, an investigational device that can be placed using minimally invasive techniques.
How Studying Cellular Senescence Can Help Researchers Learn to Delay Aging
Chronic inflammation, one of the major hallmarks of aging, is thought to be partly caused by senescent cells that may accumulate in older individuals. Now, Yale researchers have received a grant from the National Institutes of Health (NIH) Common Fund’s Cellular Senescence Network Program (SenNet) to study these specialized cells.
Yale-developed Technology Restores Cell, Organ Function in Pigs After Death
Using a new technology they developed that delivers a specially designed cell-protective fluid to organs and tissues, the researchers restored blood circulation and other cellular functions in pigs a full hour after their deaths.Source: YaleNews
Researchers Visualize the Intricate Branching of the Nervous System
When the human brain develops, axons and dendrites branch out in a beautifully intricate, yet poorly understood, way that allows nerve cells to form connections and send messages throughout the body. Yale researchers have discovered the molecular mechanism behind the growth of this complex system.
Another Byproduct of Aging: Hypermutations in the Brain
Scientists studying non-inherited, or somatic, mutations in frozen post-mortem human brains have found that about 6% of brains are much more likely to accumulate large numbers of these mutations and that these “hypermutable” brains tend to be 40 years old or older.Source: YaleNews
A New Path for Treating Brain Cancer With a Yale-developed Compound
Yale researchers have developed a new class of molecules that target some of the deadliest brain cancers while sparing healthy tissue. The discovery combines innovative synthetic chemistry and cutting-edge mechanistic studies in molecular biology, and offers a potentially powerful new approach to treating drug-resistant glioma tumors.
Lin and Greco Take Office as Leaders of Stem Cell Society
Two of Yale’s stem cell faculty— Haifan Lin, PhD, and Valentina Greco, PhD— are serving in the highest ranks of the International Society for Stem Cell Research (ISSCR). ISSCR is a global organization with more than 4,400 members from 70 countries.
Yale-developed Vaccine Offers Superior Protection Against Omicron Variants
The experimental vaccines use engineered lipid nanoparticles to deliver mRNA to cells with “instructions” to create spike proteins from mutating variants, which the virus uses to attach to and infect cells.Source: YaleNews
Scientists Zero in on Genetic Causes of Parkinson’s
In two new papers, scientists provide insight into the function of a protein called VPS13C, one of the molecular suspects that underlie Parkinson’s, a disease marked by uncontrollable movements including tremors, stiffness, and loss of balance.Source: YaleNews
How Gut Microbes Can Evolve and Become Dangerous
Gut bacteria can evolve over time within the host, becoming more pathogenic by gaining the ability to migrate across the gut barrier and persist in organs outside of the intestine, thereby driving chronic inflammation and associated pathologies.Source: YaleNews
Yale Team Develops Vaccine for Deadly Leptospirosis Bacteria
The development of a vaccine for leptospirosis would have huge implications for global public health, said senior author Joseph Vinetz, MD, with the greatest impact being in developing countries where there is a high disease burden that is completely unmet.