Search Results < Yale School of Medicine

24 results

News
Symposium Highlights Importance of Biomedical Imaging for Understanding Neurological Disease
A Neuroimaging in Neurological Disorders and Diseases Symposium at Yale highlighted how imaging technology can enhance basic neuroscience research to help scientists better understand neurological diseases.
30 Jan 2023
News
How Brain Regions Involved in Wakeful Rest May Play a Role in the Risk for Alzheimer’s Disease
Daydreaming puts the brain in a state of wakeful rest, allowing the connection of brain regions known as the Default Mode Network (DMN) to interact. The DMN is now a topic of investigation for researchers trying to understand why women are at a higher risk for Alzheimer's Disease than men.
23 Jan 2023
News
3D Organoid Models Show Brain Mechanisms of Tourette Syndrome
An absence of specialized neurons in the basal ganglia of the brain appears to be key to the presence and severity of Tourette syndrome and its associated tics, a Yale study found.
12 Jan 2023
News
Study Identifies Neuronal Basis of Impaired Consciousness in Absence Epilepsy
Using a genetic model known as Genetic Absence Epilepsy Rats of Strasbourg (GAERS), Yale researchers have identified the neuronal basis for absence epilepsy. Their findings were published Jan. 10 in Nature Communications. During absence epilepsy episodes, children experience brief staring spells, during which they temporarily lose consciousness. Absence seizures can be captured by abnormal rhythms on EEG recordings, but their neuronal cause has never before been identified.
11 Jan 2023
News
Alzheimer's Drug Validated in Yale-led Trial Gets FDA Accelerated Approval
An experimental dementia drug slowed clinical decline in people with early-stage Alzheimer’s disease in a phase 3 clinical trial. The findings led to accelerated FDA approval of the medication.
10 Jan 2023
News
Drug Slows Clinical Decline of Patients With Early-stage Alzheimer’s in Yale-led Study
An experimental dementia drug slowed clinical decline in people with early-stage Alzheimer’s disease in a phase 3 clinical trial. The findings led to accelerated FDA approval of the medication.
Source: YaleNews
5 Jan 2023
News
Potential New Treatment for “Brain Fog” in Long COVID Patients
While the number of patients they studied is too small for their results to be definitive, Yale researchers—using their extensive experience with two existing medications—have published initial evidence that those drugs, given together, can mitigate or even eliminate brain fog.
13 Dec 2022
News
Swelling Along Brain’s Axons May Be True Culprit in Alzheimer’s Disease
Yale researchers have found that the disease’s debilitating symptoms may be the result of swelling caused by amyloid plaques in the brain.
Source: YaleNews
30 Nov 2022
News
Creating New Neuropsychiatric Drug Candidates From a Virtual Library
Drug candidates identified through this process could lead to treatments for disorders such as depression or anxiety without unwanted side effects brought on by psychedelic therapies.
Source: YaleNews
29 Sep 2022
News
‘Jumping’ Genes Yield New Clues to Origins of Neurodegenerative Disease
Massive, repetitive stretches of DNA in the human genome may harbor hints about the onset of a rare, inherited neurodegenerative disorder called ataxia-telangiectasia as well as other related diseases, a new Yale School of Medicine study finds.
Source: YaleNews
6 Sep 2022
News
Yale Creates Center Devoted to Brain and Mind Health
The center will foster transformational work that bridges existing departments, levels of analysis, and disciplinary boundaries, and will focus on areas of clinical and translational neuroscience that are broader than any single disease.
30 Aug 2022
News
Does Parkinson’s Disease Begin in the Gut?
Yale research suggests that several neurodegerative diseases may originate not in the nervous system, but in the gut microbiome.
9 Aug 2022
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To Better Understand the Brain, Look at the Bigger Picture
Researchers evaluated various approaches to fMRI and found that zooming out and taking a wider field of view captures additional relevant information that a narrow focus leaves out, offering greater understanding of neural interplay.
Source: YaleNews
5 Aug 2022
News
Researchers Visualize the Intricate Branching of the Nervous System
When the human brain develops, axons and dendrites branch out in a beautifully intricate, yet poorly understood, way that allows nerve cells to form connections and send messages throughout the body. Yale researchers have discovered the molecular mechanism behind the growth of this complex system.
2 Aug 2022
News
Another Byproduct of Aging: Hypermutations in the Brain
Scientists studying non-inherited, or somatic, mutations in frozen post-mortem human brains have found that about 6% of brains are much more likely to accumulate large numbers of these mutations and that these “hypermutable” brains tend to be 40 years old or older.
Source: YaleNews
28 Jul 2022
News
The Brain’s Drainage System in 3 Dimensions
Meningeal lymphatic vessels are potential targets to treat brain diseases. Laboratories at Yale and the Paris Brain Institute (Pitié-Salpêtrière Hospital, Paris) image brain drainage by meningeal lymphatics in mice and in humans.
19 Jul 2022
News
Scientists Zero in on Genetic Causes of Parkinson’s
In two new papers, scientists provide insight into the function of a protein called VPS13C, one of the molecular suspects that underlie Parkinson’s, a disease marked by uncontrollable movements including tremors, stiffness, and loss of balance.
Source: YaleNews
14 Jul 2022
News
Experimental Drug Reverses Synaptic Loss in Mouse Models of Alzheimer’s
An experimental drug restored brain synapses in two mouse models of Alzheimer’s disease, raising hopes that it could help revive cognitive function in human dementia patients.
Source: YaleNews
1 Jun 2022
News
The Molecular Machinery That Delivers Metabolites to Mitochondria
When we eat and then digest a meal, the nutrients and other useful components in the food are broken down—or metabolized—and ultimately make their way to cells throughout the body. Hongying Shen, PhD, and her lab have identified the molecular machinery through which many of the metabolites reach inside the mitochondria in cells.
11 May 2022
News
Sleep’s Crucial Role in Preserving Memory
During sleep, our brains are busy consolidating memories and removing waste to keep our minds sharp. Recent findings from Yale on sleep hygiene and more.
10 May 2022