Symposium Highlights Importance of Biomedical Imaging for Understanding Neurological Disease
A Neuroimaging in Neurological Disorders and Diseases Symposium at Yale highlighted how imaging technology can enhance basic neuroscience research to help scientists better understand neurological diseases.
How Brain Regions Involved in Wakeful Rest May Play a Role in the Risk for Alzheimer’s Disease
Daydreaming puts the brain in a state of wakeful rest, allowing the connection of brain regions known as the Default Mode Network (DMN) to interact. The DMN is now a topic of investigation for researchers trying to understand why women are at a higher risk for Alzheimer's Disease than men.
Study Identifies Neuronal Basis of Impaired Consciousness in Absence Epilepsy
Using a genetic model known as Genetic Absence Epilepsy Rats of Strasbourg (GAERS), Yale researchers have identified the neuronal basis for absence epilepsy. Their findings were published Jan. 10 in Nature Communications. During absence epilepsy episodes, children experience brief staring spells, during which they temporarily lose consciousness. Absence seizures can be captured by abnormal rhythms on EEG recordings, but their neuronal cause has never before been identified.
Potential New Treatment for “Brain Fog” in Long COVID Patients
While the number of patients they studied is too small for their results to be definitive, Yale researchers—using their extensive experience with two existing medications—have published initial evidence that those drugs, given together, can mitigate or even eliminate brain fog.
‘Jumping’ Genes Yield New Clues to Origins of Neurodegenerative Disease
Massive, repetitive stretches of DNA in the human genome may harbor hints about the onset of a rare, inherited neurodegenerative disorder called ataxia-telangiectasia as well as other related diseases, a new Yale School of Medicine study finds.Source: YaleNews
To Better Understand the Brain, Look at the Bigger Picture
Researchers evaluated various approaches to fMRI and found that zooming out and taking a wider field of view captures additional relevant information that a narrow focus leaves out, offering greater understanding of neural interplay.Source: YaleNews
Researchers Visualize the Intricate Branching of the Nervous System
When the human brain develops, axons and dendrites branch out in a beautifully intricate, yet poorly understood, way that allows nerve cells to form connections and send messages throughout the body. Yale researchers have discovered the molecular mechanism behind the growth of this complex system.
Another Byproduct of Aging: Hypermutations in the Brain
Scientists studying non-inherited, or somatic, mutations in frozen post-mortem human brains have found that about 6% of brains are much more likely to accumulate large numbers of these mutations and that these “hypermutable” brains tend to be 40 years old or older.Source: YaleNews
Scientists Zero in on Genetic Causes of Parkinson’s
In two new papers, scientists provide insight into the function of a protein called VPS13C, one of the molecular suspects that underlie Parkinson’s, a disease marked by uncontrollable movements including tremors, stiffness, and loss of balance.Source: YaleNews
The Molecular Machinery That Delivers Metabolites to Mitochondria
When we eat and then digest a meal, the nutrients and other useful components in the food are broken down—or metabolized—and ultimately make their way to cells throughout the body. Hongying Shen, PhD, and her lab have identified the molecular machinery through which many of the metabolites reach inside the mitochondria in cells.