Yale researchers help restore hormonal balance disrupted in metabolic diseases
Now Yale scientists report March 4 in the journal Nature that they have discovered the molecular mechanisms that trigger metabolic imbalance between these two distinct but linked processes, a finding with implications for the treatment of diabetes and non-alcoholic fatty liver disease (NAFLD).
New Drugs on the Horizon for Stroke and Hydrocephalus
Kristopher Kahle, MD, assistant professor of neurosurgery and of cellular and molecular physiology at Yale School of Medicine, recently published a study describing a new compound that could reduce swelling in the brain caused by stroke or hydrocephalus.
Yale Researchers Find That Ubiquitous Protein Plays Lead Role in Cell Survival
Yale researchers have discovered that the protein polycystin 2 protects against cell death, making it a potential target for therapies to treat a variety of diseases of the liver and kidneys, as well as for brain aneurysms, heart disease, and cancer.
Molecular ‘Doormen’ Open the Way to Potential Obesity Treatment
In obese individuals, cellular "doormen" open the gates far too wide in certain key fat cells, known as visceral fat cells, letting in too many carbohydrates without first burning off lipids. This leads to a ballooning of the size of visceral fat cells in the belly.
Molecular Control of Neurotransmitter Linked to Autism Described
In two new papers published Oct. 15 in Science Signaling, researchers from Yale, France, Japan, and the United Kingdom have zeroed in on a molecular mechanism crucial to normal brain development, which, when impaired, causes autism-like symptoms in mice.
Gracheva Receives Presidential Early Career Award
Elena Gracheva, PhD, associate professor of cellular and molecular physiology and of neuroscience, has been awarded the Presidential Early Career Award for Scientists and Engineers (PECASE). The White House announced its complete list of recipients, including two additional Yale faculty members, on July 2.
Yale-led Study Reveals Biology of Leptin, the Hunger Hormone
In a new study, Yale researchers offer insight into leptin, a hormone that plays a key role in appetite, overeating, and obesity. Their findings advance knowledge about leptin and weight gain, and also suggest a potential strategy for developing future weight-loss treatments, they said.
New Strategy for Untreatable Kidney Disease: Targeting Cell Energy
The best hope for people with an inherited form of kidney disease that causes kidney failure is dialysis or a kidney transplant. But a study led by Yale researchers reveals a potential strategy for developing new drug therapies for these patients.
David W. Wallace, 1924-2017, generous and loyal benefactor
David W. Wallace, a former corporate attorney, businessman, and philanthropist who was a longtime supporter of the School of Medicine and Yale University, died at home in Greenwich, Connecticut, on Dec. 24, 2017. He was 93.Source: Medicine@Yale
A synthetic approach to helping the immune system thwart infections
Yale researchers have developed a set of synthetic molecules that may help boost the strength of a key, virus-fighting protein. The protein, RIG-I, is an important sensor in the immune system of humans and other animals. It recognizes and responds to viral RNA by surrounding it, latching onto it, and launching the immune system into action. The Yale team, led by biologists Anna Pyle and Akiko Iwasaki, has designed molecules that jump-start the process. These synthetic, stem-loop RNA (SLR) molecules can be visualized as short cords with a knot at one end. The configuration enables the SLRs to bind with RIG-I molecules in a way that prompts an aggressive response.
Leptin hormone spurs body’s shift from burning carbs to fat
To keep the human brain supplied with energy when food was scarce, mammals evolved the ability to switch from burning carbohydrates to burning fat in order to preserve skeletal muscle that would otherwise be metabolized and converted to glucose. Scientists have long believed that the transition to fat metabolism was instigated solely by a drop in insulin. But a new study has identified leptin — a hormone made by fat cells — as a key mediator in this fundamental biological process.