SLEEP-SMART Intervention Shows Promising Results for Women Suffering from Sleeping Problems, Depression, and Anxiety
Preliminary data indicate SLEEP-SMART can improve sleep patterns, show associated reductions in symptoms of depression and anxiety, and improve the functioning of brain circuits important in emotional and cognitive health.
Research Begun by WHRY Continues to Show Possible Pathway to Derail Dementia
Research is revealing the mechanisms that underlie the role of estradiol in memory so that next generation treatments for Alzheimer's disease and other dementias can specifically target these mechanisms and avoid the potential for negative side effects of systemic estrogen therapy.
Alzheimer's Disease Research Center will hold a research day on Feb. 12
The Alzheimer's Disease Research Center will be hosting a Research Day, which will include a series of lectures on current research studies on Alzheimer's Disease. The following Investigators will be presenting: Christopher van Dyck, MD; Jason Cai, PhD; Amy Arnsten, PhD; Morgan Levine, PhD; Nenad Sestan, MD,PhD; In Hyun Park, PhD; and Flora Vaccarino, MD.
How do we lose memory? A STEP at a time, researchers say
In mice, rats, monkeys, and people, aging can take its toll on cognitive function. A new study by researchers at Yale and Université de Montréal reveal there is a common denominator to the decline in all of these species — an increase in the level of the molecule striatal-enriched phosphatase, or STEP.
Research in the news: Hyperactive neurons may be culprit in Alzheimer’s
A long-term reduction in neuronal activity reduces amyloid plaques associated with Alzheimer’s disease, Yale University researchers have found. The study, using mouse models of Alzheimer’s, found the opposite is also true — triggering an increase in neuronal activity spurs creation of plaques and toxic amyloid beta peptides believed to trigger the disease.
Immune cells are an ally, not enemy, in battle against Alzheimer’s
In Alzheimer’s disease (AD), β-amyloid plaques are tightly enveloped by microglia but the significance of this phenomenon is unknown. Here the authors used confocal and in vivo two-photon imaging in AD mouse models and revealed that microglia constitute a physical barrier that prevents the formation of neurotoxic hotspots of protofibrillar β-amyloid and shields adjacent neurons and synapses from the toxic effect of amyloid plaques
Alzheimer’s missing link found: Is a promising target for new drugs
Yale School of Medicine researchers have discovered a protein that is the missing link in the complicated chain of events that lead to Alzheimer’s disease, they report in the Sept. 4 issue of the journal Neuron. Researchers also found that blocking the protein with an existing drug can restore memory in mice with brain damage that mimics the disease.
What to Do About Aducanumab? Academic Memory Programs Brace for the Tough Questions
Academic medical centers are establishing committees and workgroups to develop standards and criteria for determining eligibility for the newly-approved and controversial Alzheimer's drug, aducanumab.Source: NeurologyToday
FDA calls for federal investigation into its controversial Alzheimer’s drug approval
The head of the Food and Drug Administration has called for a wide-ranging federal investigation into the approval of Biogen’s treatment for Alzheimer’s disease just one month after a decision that sparked the ire of lawmakers, doctors, and public health advocates.Source: STAT News
MRI's Motivated by Mom
A lifetime resident of New Haven County, Kathy (71) is also a longtime supporter of clinical research at Yale. She has volunteered for many studies involving MRI (Magnetic Resonance Imaging) machines, a technique used for visualizing the brain without radiation, so scientists can learn more about the brain and clinicians will be better equipped to treat the many diseases associated with it. One of these, Alzheimer’s disease, is what first inspired Kathy to participate in research when she lost her mother to the condition.