Rheumatology Faculty Recognized at American College of Rheumatology Convergence
The American College of Rheumatology (ACR) Convergence took place November 10-14, 2022. Various faculty from the Yale Department of Internal Medicine’s Section of Rheumatology, Allergy & Immunology were recognized for their considerable contributions to the society.
Large Gift Establishes Colton Center for Autoimmunity at Yale School of Medicine
Philanthropists Judith and Stewart Colton have donated a major gift to establish the Colton Center for Autoimmunity at Yale, under the direction of Joseph E. Craft, MD, Paul B. Beeson Professor of Medicine and professor of immunobiology.
How do humans survive infections? Study pinpoints the role of a key hormone
To overcome an infection, the immune system has to both kill the invading virus or bacterium, and tolerate the inflammation triggered by the infection. In a new study, Yale researchers have figured out a key component of the second infection-fighting mechanism.
Yale enhances its cytometry capabilities
The methods and equipment used to probe cellular questions are rapidly advancing—including, at Yale, through the addition in 2014 of CyTOF, or Cytometry Time-Of-Flight, and this past June of the CyTOF Imaging Mass Cytometer (IMC), which greatly expands Yale's ability to examine specimens that are analyzed both for clinical diagnosis and for basic research.Source: Medicine@Yale
Spurring the body to repair itself
Carla Rothlin, Ph.D., who arrived at Yale in 2009, has been recognized for her basic science work within various autoimmune diseases, including asthma, lupus, Crohn’s disease, and colitis. In 2016, the Howard Hughes Medical Institute (HHMI), the Bill & Melinda Gates Foundation, and the Simons Foundation made Rothlin one of their inaugural group of HHMI Faculty Scholars, part of a program to support early-career scientists who pursue primarily basic research projects.Source: Medicine@Yale
YCCI Beginning a Second Decade of Support
Although it is hard to believe, the Yale Center for Clinical Investigation (YCCI) is now in its second decade providing training resources and support for Yale’s clinical and translational investigators. With the second renewal of the Clinical and Translational Science Award (CTSA), YCCI is well poised to continue supporting innovative science to improve the health of patients everywhere.
With the Renewal of the Yale CTSA Comes New Funding Opportunities
Yale’s status as a funded CTSA site opens several additional opportunities for external funding through National Center for Advancing Translational Sciences (NCATS). Through the NCATS’s Division of Innovation, the NIH institute and division that oversee all CTSA funding, Yale investigators can now apply for new research opportunities available only to universities with funded CTSA hubs. As part of this program, Robert Sherwin and the Yale CTSA have already been awarded three of these grants; in addition, new opportunities will continue to become available.
Lieping Chen, PhD, wins prestigious 2017 Warren Alpert Prize
Lieping Chen, Ph.D., co-director of the Cancer Immunology Program at Yale Cancer Center and United Technologies Corporation Professor in Cancer Research and professor of immunobiology, of dermatology and of medicine at Yale School of Medicine, has been presented with the 2017 Warren Alpert Foundation Prize for transformative discoveries in the field of cancer immunology.
Deputy Deans of Scientific and Faculty Affairs Appointed
The School of Medicine announced the appointment of Linda K. Bockenstedt, MD, as deputy dean for faculty affairs, Brian R. Smith, MD, as deputy dean for scientific affairs (clinical departments), and Michael C. Crair, PhD, as deputy dean for scientific affairs (basic science departments), effective July 1, 2017.
The promise of precision medicine for rheumatoid arthritis
In a new study, a Yale-led research team identified the mechanism of a gene that raises the risk of severe rheumatoid arthritis in susceptible individuals. The finding may lead to the development of treatment based on the genetic profiles of arthritis patients, the researchers said.
First new drugs in more than 50 years for Lupus; more clinical trials at Yale underway
It’s not your typical skin rash. “Lupus can give you certain kinds of rashes. This is typically described as a butterfly, so individuals can develop inflammation on the skin of their cheeks,” says Rheumatologist Dr. Fotios Koumpouras at Yale School of Medicine. He specializes in Lupus, an auto-immune disease which can cause damage, pain, and inflammation to any part of the body.Source: wtnh.com
Listening to lupus
Lupus is a mysterious chronic illness that primarily affects women in their prime of life. In people with lupus, the immune system goes awry, attacking healthy tissue. While there is no cure, there are many options for treatment, including ones being studied at Yale School of Medicine. For May, lupus awareness month, YaleNews spoke to Dr. Lenore Buckley, professor of medicine in the Section of Rheumatology, who recently launched an innovative clinical program for patients with lupus. Following is an edited version of the conversation.
Chaos, hope, and the lupus butterfly theory
Yale researchers believe some antibodies associated with lupus may be sources of both chaos and hope in cancer. Borrowing from the Greek legend of Pandora’s box and chaos theory by calling it the “lupus butterfly theory,” the idea was described recently in the journal Nature Reviews Rheumatology.
Research in the news: Yale study pinpoints key genetic factor behind autoimmune diseases, cancer
Scientists have long known that variations in specific human genes are associated with distinct patterns of disease, but an understanding of the molecular mechanisms has remained elusive until now. A team of Yale researchers has untangled that mystery for a key immune response gene, a discovery which could lead to more personalized treatment for conditions such as lupus and cancer.