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“Consider the gut microbiome as the center of the world,” says Li Wen, MD, PhD, FW ’97, associate professor of medicine (endocrinology). At the center of a lined notepad, Wen draws a circle: this is the gut microbiome.
Last May, 15-year-old Jacob Conte was scaling a rock wall at City Climb Gym in New Haven. Hand over hand, grabbing onto holds protruding from the wall, he made his way up the artificial cliff.
With a name that derives from the Greek word for “thin,” the leptin hormone regulates the amount of fat stored in the body by controlling the feeling of hunger. It was discovered in 1994, with high hopes that it would provide a groundbreaking treatment for a growing national epidemic of obesity.
Gerald I. Shulman, M.
When Kelly Brownell, Ph. D.
Even on a “supersize” diet, mice bred to lack a certain enzyme remained more svelte than mice with the enzyme, according to a study by Yale scientists in the July 2006 issue of the journal Cell Metabolism. Moreover, in a finding that surprised the research team, the mice’s blood sugar levels..
Jonathan and Bonnie Rothberg share not only a home and family but also a passion for probing the mysteries of the human genome. Together and separately, they attempt both to untangle genetic differences among individuals that can affect disease and to develop novel treatments that target disease..
Part of a national effort to create community health partnerships, a Yale center is working with New Haven churches to prevent diabetes and with suburban school nurses to stop teen smoking. The goal? Healthier communities invested in their own outcomes.
After becoming an expert in nutrition, obesity and chronic-disease prevention, David L. Katz, M.
It’s a heart-rending legacy: mothers who have uncontrolled diabetes during pregnancy are three times more likely to give birth to babies with malformed hearts than are mothers whose blood sugar levels are normal. Doctors have known that for some time, but recent work by researchers at Yale and..
The rise in obesity around the country has led a number of investigators to seek solutions in the realm of public policy. Among those is Kelly D.
Type 2 diabetes poses alarming health risks as obesity soars and exercise is crowded from modern life. Yale investigators are seeking better ways to prevent and treat the disease and to understand the science of fat.
“Everything about diabetes cuts two ways,” says William Tamborlane, M. D.