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The protein filamin and its close relatives help assemble filaments of the protein actin into a kind of cellular skeleton. A number of genetic diseases result from defects in this cytoskeleton.
Immune checkpoint inhibitors are drugs designed to turn the immune system into a cancer-destroying weapon. However it appears that certain tumors, such as those associated with colorectal cancers, possess immune-suppressive mechanisms that thwart such therapies.
For a quarter century, Ginny Grunley, her husband Ken Grunley, president and chief executive officer of Grunley Construction, Inc. , and their family have been enthusiastic philanthropists.
A growing number of cancer drugs are designed to shut off epidermal growth factor receptor (EGFR), a protein known to be involved in a wide array of cellular processes including proliferation. Now, Yale researchers have answered a long-standing question about how EGFR can mediate so many diverse..
Growing up in Buenos Aires, Argentina’s capital city, Carla V. Rothlin, Ph.
The human body’s macrophages—a type of immune cell—not only fight off invading pathogens, but also help repair injured tissue after an infection. Yale researchers have now discovered what triggers macrophages to switch from attack mode to rebuilding mode.
A Yale-led research team has found that a fundamental cellular process can be interrupted to disable certain cancerous cells. During the process of glycosylation, an enzyme called oligosaccha-ryltransferase (OST) helps transfer chains of saccharides to specific proteins to help those proteins..
Marina Picciotto, Ph. D.
A $9. 5 million, five-year grant from the National Cancer Institute (NCI) will fund an intensive multidisciplinary research effort that seeks to better understand how cancer cells reach an aggressive state and begin to damage surrounding tissue.
Naftali Kaminski, M. D.
Stefania Nicoli, Ph. D.
Two Yale scientists have been named to the Royal Society, the United Kingdom’s national academy of science. Mark A.
In 2011 the School of Medicine formed a research alliance with the biopharmaceutical company Gilead Sciences, Inc. to accelerate the discovery and development of new drugs to treat cancer.
In the 1980s, immunotherapy researcher Lieping Chen, M. D.
Nicholas Downing, a student in the School of Medicine’s Class of 2014, has been named one of Forbes magazine’s 30 most influential people under the age of 30. In 2011, as a first-year student, Downing began comparing the speed with which the U.
Imagine trying to develop a drug and being able to see how and where that drug acts inside the body of a living person. Just such a tool is provided by positron emission tomography (PET), an imaging technology that is aiding drug development and research on the mechanisms of disease at the..
Doctors and patients who are impatient for new drugs to hit the market often get the sense that the United States’ drug approval process is a long and slow road. But a new study by School of Medicine researchers found that the U.
Recent experiments in which stretches of proteins and genetic material are inserted into bacteria to silence genes have shown great promise as a means of treating bacterial infection. By inactivating genes such as those a bacterium needs to copy its genome, or those that help it to resist..
Cancer is relentless, so perseverance is essential in those who hope to vanquish it. Alan C.