2023
Sex Difference in Outcomes of Acute Myocardial Infarction in Young Patients
Sawano M, Lu Y, Caraballo C, Mahajan S, Dreyer R, Lichtman J, D'Onofrio G, Spatz E, Khera R, Onuma O, Murugiah K, Spertus J, Krumholz H. Sex Difference in Outcomes of Acute Myocardial Infarction in Young Patients. Journal Of The American College Of Cardiology 2023, 81: 1797-1806. PMID: 37137590, DOI: 10.1016/j.jacc.2023.03.383.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionNoncardiac hospitalizationsSubdistribution HRYounger patientsMyocardial infarctionSex differencesYoung womenCause-specific hospitalizationsCause of hospitalizationWorse health statusSignificant sex disparityNoncardiovascular hospitalizationsVIRGO StudyIndex episodeAdverse outcomesIncidence rateHospitalizationHigh riskSex disparitiesHealth statusPatientsU.S. hospitalsWomenInfarctionOutcomes
2022
Young Women With Acute Myocardial Infarction: Risk Prediction Model for 1-Year Hospital Readmission
Dreyer R, Arakaki A, Raparelli V, Murphy T, Tsang S, D’Onofrio G, Wood M, Wright C, Pilote L. Young Women With Acute Myocardial Infarction: Risk Prediction Model for 1-Year Hospital Readmission. CJC Open 2022, 5: 335-344. PMID: 37377522, PMCID: PMC10290947, DOI: 10.1016/j.cjco.2022.12.004.Peer-Reviewed Original ResearchAcute myocardial infarctionRisk prediction modelHospital readmissionYoung womenMyocardial infarctionYoung AMI Patients (VIRGO) studyObstructive coronary artery diseaseRisk of readmissionCongestive heart failureProspective observational studyCoronary artery diseaseYoung female patientHospital readmission riskHospital complicationsHospital stayYounger patientsArtery diseaseClinical factorsHeart failureFemale patientsReadmission riskObservational studyModest discriminationHigh riskDepressive symptomsSex Differences in Clopidogrel Effects Among Young Patients With Acute Coronary Syndrome: A Role for Genetics?
Kaur A, Dreyer R, Marsh T, Thanassoulis G, Raparelli V, D’Onofrio G, Engert J, Pilote L. Sex Differences in Clopidogrel Effects Among Young Patients With Acute Coronary Syndrome: A Role for Genetics? CJC Open 2022, 4: 970-978. PMID: 36444366, PMCID: PMC9700217, DOI: 10.1016/j.cjco.2022.07.013.Peer-Reviewed Original ResearchAcute coronary syndromeUsers of clopidogrelCoronary syndromeClinical outcomesMultivariable logistic regression modelSex differencesAdverse clinical outcomesWorse clinical outcomesTime of presentationGenetic risk scoreLogistic regression modelsSex-specific impactClopidogrel usersAtherothrombotic eventsCardiac eventsYounger patientsClopidogrel effectAntiplatelet agentsClopidogrelHigh riskRisk scoreIndependent factorsRole of sexHealth outcomesReadmission