2023
Early emergency department experience with 7‐day extended‐release injectable buprenorphine for opioid use disorder
D'Onofrio G, Perrone J, Hawk K, Cowan E, McCormack R, Coupet E, Owens P, Martel S, Huntley K, Walsh S, Lofwall M, Herring A, Investigators T. Early emergency department experience with 7‐day extended‐release injectable buprenorphine for opioid use disorder. Academic Emergency Medicine 2023, 30: 1264-1271. PMID: 37501652, PMCID: PMC10822018, DOI: 10.1111/acem.14782.Peer-Reviewed Original ResearchConceptsOpioid use disorderEmergency departmentUse disordersSevere opioid use disorderOngoing clinical trialsEuropean Medicines AgencyEmergency department experienceInjectable buprenorphineClinician barriersED patientsED settingEmergency cliniciansInsurance statusClinical trialsReferral sitesDrug AdministrationMedicines AgencyBuprenorphine preparationsMedicationsU.S. FoodTreatment innovationsBuprenorphineDepartment's experienceEarly experienceDisorders
2022
Models for Implementing Emergency Department–Initiated Buprenorphine With Referral for Ongoing Medication Treatment at Emergency Department Discharge in Diverse Academic Centers
Whiteside LK, D'Onofrio G, Fiellin DA, Edelman EJ, Richardson L, O'Connor P, Rothman RE, Cowan E, Lyons MS, Fockele CE, Saheed M, Freiermuth C, Punches BE, Guo C, Martel S, Owens PH, Coupet E, Hawk KF. Models for Implementing Emergency Department–Initiated Buprenorphine With Referral for Ongoing Medication Treatment at Emergency Department Discharge in Diverse Academic Centers. Annals Of Emergency Medicine 2022, 80: 410-419. PMID: 35752520, PMCID: PMC9588652, DOI: 10.1016/j.annemergmed.2022.05.010.Peer-Reviewed Original ResearchConceptsOpioid use disorderUse disordersEmergency Department-Initiated BuprenorphineEmergency department dischargeEmergency department patientsElectronic medical record integrationAcademic medical centerBuprenorphine programDepartment patientsTreatment initiationMedication treatmentEmergency physiciansMedical CenterAmerican CollegeClinical practiceImplementation facilitationQuality improvement processBuprenorphineCommon facilitatorsRecord integrationPatientsReferralED cultureEducational disseminationDisorders
2021
Implementation of Oral and Extended-Release Naltrexone for the Treatment of Emergency Department Patients With Moderate to Severe Alcohol Use Disorder: Feasibility and Initial Outcomes
Anderson ES, Chamberlin M, Zuluaga M, Ullal M, Hawk K, McCormack R, D'Onofrio G, Herring AA. Implementation of Oral and Extended-Release Naltrexone for the Treatment of Emergency Department Patients With Moderate to Severe Alcohol Use Disorder: Feasibility and Initial Outcomes. Annals Of Emergency Medicine 2021, 78: 752-758. PMID: 34353648, DOI: 10.1016/j.annemergmed.2021.05.013.Peer-Reviewed Original ResearchConceptsAlcohol use disorderSevere alcohol use disorderFormal addiction treatmentIntramuscular naltrexoneOral naltrexoneUse disordersAddiction treatmentED patientsExtended-release naltrexoneEffectiveness of naltrexoneEmergency department patientsED dischargeAdult patientsDepartment patientsNaltrexone treatmentEmergency departmentMean ageEffective treatmentNaltrexonePatientsClinical protocolsBrief interventionDescriptive studyDisordersInitial outcomesMerging statewide data in a public/university collaboration to address opioid use disorder and overdose
Becker WC, Heimer R, Dormitzer CM, Doernberg M, D’Onofrio G, Grau LE, Hawk K, Lin HJ, Secora AM, Fiellin DA. Merging statewide data in a public/university collaboration to address opioid use disorder and overdose. Addiction Science & Clinical Practice 2021, 16: 1. PMID: 33397480, PMCID: PMC7780404, DOI: 10.1186/s13722-020-00211-9.Peer-Reviewed Original Research
2019
Computerized Clinical Decision Support System for Emergency Department–Initiated Buprenorphine for Opioid Use Disorder: User-Centered Design
Ray JM, Ahmed OM, Solad Y, Maleska M, Martel S, Jeffery MM, Platts-Mills TF, Hess EP, D’Onofrio G, Melnick ER. Computerized Clinical Decision Support System for Emergency Department–Initiated Buprenorphine for Opioid Use Disorder: User-Centered Design. JMIR Human Factors 2019, 6: e13121. PMID: 30810531, PMCID: PMC6414819, DOI: 10.2196/13121.Peer-Reviewed Original ResearchOpioid use disorderRoutine emergency careEmergency departmentCare pathwayED initiationClinical decision supportEmergency careUse disordersEmergency Department-Initiated BuprenorphineRoutine ED careComputerized clinical decision support systemsEffective treatment optionClinical decision toolClinical decision support systemED careTreatment optionsBuprenorphineResident physiciansDirect activationCarePatientsDisordersCritical decision pointsInitial observationsPathway
2018
Emergency department screening and interventions for substance use disorders
Hawk K, D’Onofrio G. Emergency department screening and interventions for substance use disorders. Addiction Science & Clinical Practice 2018, 13: 18. PMID: 30078375, PMCID: PMC6077851, DOI: 10.1186/s13722-018-0117-1.Peer-Reviewed Original Research
2013
A Promising Approach For Emergency Departments To Care For Patients With Substance Use And Behavioral Disorders
Bernstein SL, D’Onofrio G. A Promising Approach For Emergency Departments To Care For Patients With Substance Use And Behavioral Disorders. Health Affairs 2013, 32: 2122-2128. PMID: 24301395, DOI: 10.1377/hlthaff.2013.0664.Peer-Reviewed Original ResearchConceptsEmergency departmentPrimary care systemSubstance useBehavioral disordersCare systemAcuity of illnessUS emergency departmentsHigh patient volumeNation's primary care systemMillions of patientsHealth care systemED patientsBody of evidenceBrief interventionPatientsPatient volumeSBIRTMotivational interviewingHealth of millionsDisordersRisky behaviorsCounseling techniquesReflective listeningDepartmentAcuity