Ruth Montgomery, PhD

Professor; Director, Yale CyTOF Facility; Associate Dean for Scientific Affairs

Departments & Organizations

Internal Medicine: Rheumatology: Rheumatic Diseases Research Core | Rheumatology, Allergy, & Immunology: Rheumatology: Rheumatic Diseases Research Core

Laboratory Medicine

Pathology: Experimental Pathology Graduate Program

School of Public Health: Epidemiology of Microbial Diseases

Center for Biomedical Data Science

Human and Translational Immunology Program

Yale Center for Research on Aging (Y-Age)

Mobile @ Yale


Ruth R. Montgomery is a cellular immunologist with particular expertise in use of novel technology for human translational studies. Her research employs systems wide studies to identify individual differences in immune responses that lead to divergent outcomes to infection. Her group focuses on effects of aging on innate immunity and individual variation influencing susceptibility to West Nile, dengue, and Zika viruses, among others. She has overseen studies of immune responsiveness in human cohorts with successful enrollment of >1800 healthy individuals. Dr. Montgomery’s work is notable for her use of primary human cells to demonstrate immune related mechanisms and illuminate potential avenues for therapeutic interventions. She is Director of the CyTOF facility, co-chair of the University Provost’s ITS Advisory Committee (ITSAC), and Associate Dean for Scientific Affairs.

Education & Training

PhD Rockefeller University (1987)
BA University of Pennsylvania, Biology (1981)
Fellow Yale University

Professional Service

  • Society of Leukocyte Biology (2017 - Present) Council Member

  • Nature Journal of Molecular Phenomics (2017 - Present) Associate Editor

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Contact Info

Ruth Montgomery, PhD
Mailing Address
RheumatologyPO Box 208056
333 Cedar Street

New Haven, CT 06520-8056
Differentiated NK repertoires are skewed toward cytokine production in response to virus-infected cells.

Increase in diversity of NK cell receptors following infection with virus. Sci Trans Med 7:297ra115. PMCID:PMC4547537

Research Image 2

Ixodes tick, vector of Lyme disease