Yadong Wang
Associate Research Scientist in GeneticsCards
About
Research
Publications
2024
Lipocoacervate, a tunable vesicle for protein delivery
Yeh C, Wright N, Loh C, Chu N, Wang Y. Lipocoacervate, a tunable vesicle for protein delivery. Nano Research 2024, 1-6. DOI: 10.1007/s12274-024-6889-6.Peer-Reviewed Original ResearchProtein delivery vehiclesDelivery of proteinsCells in vitroGrowth factorVesiclesProteinMembrane functionControlled delivery of growth factorsTreated cells in vitroProtein deliveryControlled deliveryControlled delivery of proteinsDelivery of therapeuticsSalt concentrationDelivery of growth factorsMembraneVesicle sizeControlled delivery of therapeuticsCardiac regeneration in goldfish (Carassius auratus) associated with increased expression of key extracellular matrix molecules
Webb C, Wang Y. Cardiac regeneration in goldfish (Carassius auratus) associated with increased expression of key extracellular matrix molecules. The Anatomical Record 2024 PMID: 39092661, DOI: 10.1002/ar.25549.Peer-Reviewed Original ResearchNorbornene Dicarboximide: A Green Alternative for Thiol-Norbornene Photopolymers
Ma W, Wright N, Wang Y. Norbornene Dicarboximide: A Green Alternative for Thiol-Norbornene Photopolymers. ACS Macro Letters 2024, 915-920. PMID: 38991097, DOI: 10.1021/acsmacrolett.4c00334.Peer-Reviewed Original ResearchCarbic anhydrideTunable tensile propertiesPolymer backboneDigital light processingThiol cross-linkingHuman aorta modelAnhydrideCommodity polymersPolypropylene glycolPorous scaffoldsTensile propertiesSoft materialsGreen alternativeLight processingAorta modelCross-linkingFunctional surfacesPolymerThiolPhotopolymerNorborneneAminolysisPhotoadditionStoichiometryMaterialsTransformation of metallo-elastomer grafts in a carotid artery interposition model over a year
Chen Y, Dombaxe C, D'Amato A, Van Herck S, Welch H, Fu Q, Zhang S, Wang Y. Transformation of metallo-elastomer grafts in a carotid artery interposition model over a year. Biomaterials 2024, 309: 122598. PMID: 38696943, DOI: 10.1016/j.biomaterials.2024.122598.Peer-Reviewed Original ResearchABA Block Copolyester Thiol–Ene Resin From Triethylborane-Assisted Ring-Opening Copolymerization
Ma W, Miller P, Wang Y. ABA Block Copolyester Thiol–Ene Resin From Triethylborane-Assisted Ring-Opening Copolymerization. ACS Applied Polymer Materials 2024, 6: 1503-1513. DOI: 10.1021/acsapm.3c02745.Peer-Reviewed Original ResearchProtocol for transplanting pancreatic islets into the parametrial fat pad of female mice
Tedla M, Wright N, Yolcu E, Wang Y, Shirwan H. Protocol for transplanting pancreatic islets into the parametrial fat pad of female mice. STAR Protocols 2024, 5: 102816. PMID: 38180833, PMCID: PMC10801339, DOI: 10.1016/j.xpro.2023.102816.Peer-Reviewed Original ResearchA CXCR3-Activating Peptide Increases Tear Break Up Time and Corrects Corneal haze in a Rabbit Model of Environmental Dry Eye.
Wells A, Wang Y, Shao H, Sohnen P, Swamynathan S. A CXCR3-Activating Peptide Increases Tear Break Up Time and Corrects Corneal haze in a Rabbit Model of Environmental Dry Eye. Journal Of Pharmacy And Pharmacology Research 2024, 8: 23-27. PMID: 38736523, PMCID: PMC11086663, DOI: 10.26502/fjppr.094.Peer-Reviewed Original ResearchDry eye diseaseCorneal hazeKeratoconjunctivitis siccaTear qualityDry eye disease casesTear break-up timeHuman conjunctival epithelial cellsBreak-up timeConjunctival epithelial cellsInjection of peptideNew Zealand white rabbitsCorneal inflammationIncreased goblet cell numbersSubconjunctival injectionCorneal pathologyDry eyeZealand white rabbitsActivates CXCR3Eye diseaseTear stabilityInflammatory stimuliChemical injuryEpithelial cellsInflammatory responseEyedrops
2022
Dual-targeted enzyme-sensitive hyaluronic acid nanogels loading paclitaxel for the therapy of breast cancer
Gao D, Asghar S, Ye J, Zhang M, Hu R, Wang Y, Huang L, Yuan C, Chen Z, Xiao Y. Dual-targeted enzyme-sensitive hyaluronic acid nanogels loading paclitaxel for the therapy of breast cancer. Carbohydrate Polymers 2022, 294: 119785. PMID: 35868795, DOI: 10.1016/j.carbpol.2022.119785.Peer-Reviewed Original ResearchConceptsBreast cancerHyaluronic acid nanogelsTumor-bearing BALB/c miceTherapy of breast cancerTreatment of breast cancerTargeting breast cancerBreast cancer cellsRat pharmacokinetic profilesIn vivo studiesTherapeutic efficacyBALB/c miceEntrapment efficiencyPharmacokinetic profileCancer cellsClearance rateCD44 receptorControl groupCancerPaclitaxelDrug loadingHigher cytotoxicityReceptorsCD44DrugCellsPigment epithelium-derived factor engineered to increase glycosaminoglycan affinity while maintaining bioactivity
Chu H, Rebustini I, Becerra S, Wang Y. Pigment epithelium-derived factor engineered to increase glycosaminoglycan affinity while maintaining bioactivity. Biochemical And Biophysical Research Communications 2022, 605: 148-153. PMID: 35334413, DOI: 10.1016/j.bbrc.2022.03.079.Peer-Reviewed Original ResearchConceptsPigment epithelium-derived factorEpithelium-derived factorNegatively charged extracellular matrixInhibit endothelial cell proliferationAmino acid sequenceHyaluronic acidEndothelial cell proliferationExtracellular matrixRetinal degenerationRetinal diseasesRetinal microenvironmentProtect photoreceptorsTherapeutic effectVitreous humorProtein engineeringGlycosaminoglycan affinitySecreted proteinsTherapeutic drugsTube formationTissue homeostasisCell deathCell proliferationEfficient therapeutic drugsCationic residuesBinding assays
2021
Editorial for Special Issue on Oncology and Tissue Engineering
Wang Y, Wang T. Editorial for Special Issue on Oncology and Tissue Engineering. Tissue Engineering Part A 2021, 27: 437-437. PMID: 33891490, DOI: 10.1089/ten.tea.2021.29024.ywa.Peer-Reviewed Original Research