2019
Terminal Erythroid Maturation Is Associated with Dynamic Changes in the Abundance of Histone Marks Associated with Active Transcription Elongation and RNA Polymerase II Pausing
Murphy Z, Couch T, Lillis J, Getman M, Lezon-Geyda K, Schulz V, Narla M, Gallagher P, Steiner L. Terminal Erythroid Maturation Is Associated with Dynamic Changes in the Abundance of Histone Marks Associated with Active Transcription Elongation and RNA Polymerase II Pausing. Blood 2019, 134: 154. DOI: 10.1182/blood-2019-129561.Peer-Reviewed Original ResearchRNA polymerase II pausingTerminal erythroid maturationPol IIC-terminal domainErythroid maturationGene expressionTranscription elongationPosttranslational modificationsSpecific histone posttranslational modificationsPol II C-terminal domainRNA polymerase II pause releaseKey regulatorHistone H4 lysine 16 acetylationHistone H4 lysine 20Histone post-translational modificationsH4 lysine 16 acetylationHistone H3 lysine 79H4 lysine 20Histone posttranslational modificationsRNA Pol IIH3 lysine 79Multiple histone marksPost-translational modificationsTranscription start siteChIP-seq data
2008
Local and Distant Elements Regulate Tissue-Specific Expression of ANK-1 Gene Transcripts
Owen A, Laflamme K, Pilon A, Garrett L, Gallagher P, Bodine D. Local and Distant Elements Regulate Tissue-Specific Expression of ANK-1 Gene Transcripts. Blood 2008, 112: 2432. DOI: 10.1182/blood.v112.11.2432.2432.Peer-Reviewed Original ResearchNon-erythroid cellsHypersensitive sitesTransient transfection assaysConsensus sequenceChromatin loopsGATA-1NF-E2Promoter sequencesKb regionHistone acetylationErythroid transcription factor NF-E2Transfection assaysFirst exonDNase IErythroid cellsDevelopmental stage-specific patternsLocal chromatin architectureProtein-coding genesChromatin conformation captureANK-1 geneRNA Pol IITranscription initiation complexErythroid K562 cellsDNase hypersensitive sitesGATA-1 binding