2024
Mitochondria as therapeutic targets in assisted reproduction
Yildirim R, Seli E. Mitochondria as therapeutic targets in assisted reproduction. Human Reproduction 2024, 39: 2147-2159. PMID: 39066614, DOI: 10.1093/humrep/deae170.Peer-Reviewed Original ResearchMitochondrial replacement therapyClinical trialsAssisted reproductionImprove oocyte qualityTherapeutic targetAssisted reproductive outcomesImprove assisted reproductive outcomesMitochondrial quality control mechanismsDevelopmental competenceOocyte qualityReplacement therapyProgrammed cell deathQuality control mechanismsPharmacological agentsTargeting mitochondrial functionCalcium homeostasisReproductive outcomesInhibitor rapamycinMammalian targetMaternal spindle transferAntioxidant coenzyme Q10Mitochondrial populationEmbryo developmentCoenzyme Q10Cell death
2018
Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre‐implantation embryos
Wang T, Babayev E, Jiang Z, Li G, Zhang M, Esencan E, Horvath T, Seli E. Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre‐implantation embryos. Aging Cell 2018, 17: e12784. PMID: 29851234, PMCID: PMC6052477, DOI: 10.1111/acel.12784.Peer-Reviewed Original ResearchConceptsMitochondrial unfolded protein responseUnfolded mitochondrial proteinsCaseinolytic peptidase PAbsence of ClpPUnfolded protein responsePre-implantation embryosExpression of genesOocyte mitochondrial functionTwo-cell embryosProtein homeostasisMTOR inhibitor rapamycinMitochondrial proteinsOocyte competenceClpPProtein responseInhibitor rapamycinMitochondrial functionP-Akt473P-S6KOvarian follicular reserveSmall mitochondriaMTOR pathway activationPathway activationEmbryosP-S6