Life on the edge: Therapeutic uses of cytotoxic natural products
Crews C, Leuenroth S, Okuhara D, Shotwell J, Markowitz G, Yu Z, Somlo S. Life on the edge: Therapeutic uses of cytotoxic natural products. The FASEB Journal 2007, 21: a38-a38. DOI: 10.1096/fasebj.21.5.a38-b.Peer-Reviewed Original ResearchAutosomal dominant polycystic kidney diseaseCytotoxic concentrationsPhase I clinical trialLei Gong TengDominant polycystic kidney diseasePolycystic kidney diseaseKidney diseaseChinese medicinal herbsClinical trialsMurine modelCyst formationClinical potentialTriptolideTherapeutic usesDrug developmentMedicinal herbsCytotoxic activityCalcium channel polycystin-2Cytostatic signalsPolycystin-2Cytotoxic compoundsNatural products