2015
Characterization of a Small‐molecule Modulator of IRE1α Activity
Salami‐Oyenuga J, Raina K, Crews C. Characterization of a Small‐molecule Modulator of IRE1α Activity. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.723.2.Peer-Reviewed Original ResearchUnfolded protein responseHuman IRE1αIRE1α activityInositol-Requiring Enzyme 1X-box binding protein 1 (XBP1) mRNAER stress conditionsEnzymatic activitySmall molecule modulatorsMechanism of regulationER stress responseHEK293T cellsThermal shift assayER stress pathwayEndoplasmic reticulum stressCellular processesER lumenUPR signalingShift assaysIRE1α activationProtein responseHuman kidney cellsIRE1α kinaseStress responseIRE1α proteinCentral player
2001
The ubiquitin‐proteasome pathway and proteasome inhibitors
Myung J, Kim K, Crews C. The ubiquitin‐proteasome pathway and proteasome inhibitors. Medicinal Research Reviews 2001, 21: 245-273. PMID: 11410931, PMCID: PMC2556558, DOI: 10.1002/med.1009.Peer-Reviewed Original ResearchConceptsUbiquitin-proteasome pathwayComplex biochemical machineryHuman diseasesDiverse cellular processesImportant cellular substratesMajor cellular networksCellular processesBiochemical machineryProtein degradationNatural proteasome inhibitorsCellular substratesCentral playerIntracellular processesMode of actionProteasome inhibitorsPathwayMolecular probesInhibitorsPotential therapeutic agentProteasomeImportant componentMachineryRegulationTherapeutic agents