2021
Endogenous retroviruses mediate IFN-independent protection against vaginal HSV-2 infection
Tokuyama M, Jayewickreme R, Mao T, Philbrick W, Kong Y, Dong H, Treger R, Rakib T, Iwasaki A. Endogenous retroviruses mediate IFN-independent protection against vaginal HSV-2 infection. The Journal Of Immunology 2021, 206: 20.39-20.39. DOI: 10.4049/jimmunol.206.supp.20.39.Peer-Reviewed Original ResearchHSV-2 infectionVaginal HSV-2 infectionTight junction proteinsB6 miceVaginal epitheliumHerpes simplex virus type 2 infectionSimplex virus type 2 infectionEnhanced type I interferonIntravaginal HSV-2 infectionVirus type 2 infectionToll-like receptor 7Epithelial tight junction proteinsEndogenous retrovirusesReceptor-deficient miceJunction proteinsType 2 infectionHigh systemic levelsWildtype C57BL/6 miceType I interferonDisease courseC57BL/6 miceInfectious endogenous retrovirusReceptor 7Disease burdenHSV-2
2010
Antiviral immune responses in the genital tract: clues for vaccines
Iwasaki A. Antiviral immune responses in the genital tract: clues for vaccines. Nature Reviews Immunology 2010, 10: 699-711. PMID: 20829886, PMCID: PMC3678359, DOI: 10.1038/nri2836.Peer-Reviewed Original ResearchConceptsGenital mucosaT cellsGenital tractHerpes simplex virus type 2Simplex virus type 2Innate immune cellsT cell populationsAntiviral immune responseFemale genital tractPattern recognition receptorsVirus type 2Immune correlatesMemory CD4Memory CD8Viral clearanceHuman papillomavirusImmune cellsMemory lymphocytesSuccessful vaccineHIV-1Immune responseSevere diseaseVaginal epitheliumAdaptive immunityTarget cell type
2008
T helper dependent CTL migration into the vaginal mucosa
Nakanishi Y, Lu B, Gerard C, Iwasaki A. T helper dependent CTL migration into the vaginal mucosa. The FASEB Journal 2008, 22: 852.5-852.5. DOI: 10.1096/fasebj.22.1_supplement.852.5.Peer-Reviewed Original ResearchCD4 helpCTL migrationVaginal mucosaIFN-inducible chemokinesIFN-γ productionSecretion of IFNChemokine receptor CXCR3Site of infectionAntiviral host defenseMucosal sitesChemokine secretionReceptor CXCR3T helpT lymphocytesVirus infectionVaginal epitheliumHelpless miceMouse modelMucosal tissuesHost defenseVirus 2InfectionInfection siteMucosaSecretion
2004
In Vivo Role of Nectin-1 in Entry of Herpes Simplex Virus Type 1 (HSV-1) and HSV-2 through the Vaginal Mucosa
Linehan MM, Richman S, Krummenacher C, Eisenberg RJ, Cohen GH, Iwasaki A. In Vivo Role of Nectin-1 in Entry of Herpes Simplex Virus Type 1 (HSV-1) and HSV-2 through the Vaginal Mucosa. Journal Of Virology 2004, 78: 2530-2536. PMID: 14963155, PMCID: PMC369262, DOI: 10.1128/jvi.78.5.2530-2536.2004.Peer-Reviewed Original ResearchConceptsHSV-2HSV-1Viral entryNectin-1Genital herpesGenital mucosaVaginal epitheliumVaginal mucosaHerpes simplex virus type 2Simplex virus type 2Primary genital herpesHerpes simplex virus type 1Mouse vaginal epitheliumFemale genital tractSimplex virus type 1Virus type 1Virus type 2Intravaginal inoculationHSV infectionMenstrual cycleVaginal infectionsGenital tractMouse modelEstrous cycleType 2
2002
Expression of DC-SIGN by Dendritic Cells of Intestinal and Genital Mucosae in Humans and Rhesus Macaques
Jameson B, Baribaud F, Pöhlmann S, Ghavimi D, Mortari F, Doms RW, Iwasaki A. Expression of DC-SIGN by Dendritic Cells of Intestinal and Genital Mucosae in Humans and Rhesus Macaques. Journal Of Virology 2002, 76: 1866-1875. PMID: 11799181, PMCID: PMC135921, DOI: 10.1128/jvi.76.4.1866-1875.2002.Peer-Reviewed Original ResearchConceptsDC-SIGN expressionDendritic cellsDC-SIGNHuman immunodeficiency virus (HIV) transmissionRhesus macaquesDC-SIGNR expressionDistinct DC populationsSolitary lymphoid nodulesSubepithelial dendritic cellsSubepithelial dome regionTriple colour analysisPlasmacytoid dendritic cellsVirus transmissionDC-SIGNRIntact vaginal mucosaSpecific ICAM-3DC populationsHIV coreceptorsGenital mucosaLangerhans cellsPeyer's patchesGenital tractTerminal ileumInterfollicular regionsVaginal epithelium