Yung-Chi Cheng, PhD

Henry Bronson Professor of Pharmacology; Chairman, Consortium for the Globalization of Chinese Medicine (CGCM)

Research Departments & Organizations

Liver Center

Virology Laboratories

Yale Cancer Center: Developmental Therapeutics

Yale Stem Cell Center

Office of Cooperative Research

Research Interests

China; Drugs, Chinese Herbal; Hong Kong; Medicine, Chinese Traditional; Neoplasms by Histologic Type; Pharmacology

Research Summary

Our laboratory focuses on cancer and viral chemotherapy. We are studying the functional roles and properties of virus-specific proteins in order to design selective antiviral compounds. Some anti-HIV drugs have selective action against mitochondrial DNA synthesis that could lead to toxicity. This observation offered the opportunity to develop new antiviral drugs without such side effects and to examine the role of mitochondrial DNA synthesis in nuclear DNA synthesis. A new class of biological active nucleoside analogs, L(-)nucleosides were discovered. Drug resistance is a critical issue in cancer chemotherapy.

Our laboratory is interested in exploring the mechanisms of drug resistance development, with a special emphasis on the process involved in DNA topoisomerase, targeting drugs and nucleoside analogs. The gene regulator and the inhibitors may not only have use as cancer chemotherapeutic agents, but also in controlling the development of drug resistance. Several novel compounds targeting on NF-KB were discovered by my laboratory and are currently being studied. To exploreChinese medicine for current clinical usage is also pursued.

Specialized Terms; Cancer; Viral chemotherapy; Chinese herbs; Chinese medicine

Activities

  • Globalization of Chinese Medicine China; Hong Kong (2008)

    Professor Yung-chi Cheng of the Yale School of Medicine has been working with the University of Hong Kong, Peking University, Tsinghua University, and a number of other prominent Chinese institutions to form a Consortium for the Globalization of Chinese Medicine. The Consortium brings together a...

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Contact Info

Yung-Chi Cheng, PhD
Mailing Address
PharmacologyPO Box 208066
333 Cedar Street

New Haven, CT 06520-8066

Curriculum Vitae