Yi-Hwa Liu, PhD

Senior Research Scientist in Medicine (Cardiology)

Research Departments & Organizations

Internal Medicine: Yale Translational Research Imaging Center (Y-TRIC)

Office of Cooperative Research

Research Interests

Cardiology; Myocardial Perfusion Imaging; Nuclear Medicine; Ventricular Function, Left

Research Summary

My primary research has focused on new developments of automatic quantification and iterative image restoration and reconstruction methods for nuclear cardiac tomographic imaging. The new developments promise to improve image resolution and enhance detection of abnormalities of myocardial perfusion and left ventricular function. My latest work is focused on small animal imaging techniques using hybrid coded aperture collimation, and developments of “hot-spot” quantification methods for molecular targeted cardiac images using innovative stochastic methodology incorporated with dual-isotope SPECT and hybrid SPECT/CT imaging techniques. I am also involved in developments of remote reading strategy for nuclear cardiac studies using secured World-Wide-Web technology.

Specialized Terms: Nuclear Cardiac Imaging

Selected Publications

  • Iterative reconstruction of multi-pinhole SPECT

    Ryder WJ, Brennan MP, Sinusas AJ, Liu YH. Iterative reconstruction of multi-pinhole SPECT. Proceedings of the SPIE 20081613:69132M1-10. 2008

  • Hotspot quantification of myocardial focal tracer uptake from molecular targeted SPECT/CT images: canine validation.

    Liu YH, Sahul Z, Weyman CA, Ryder WJ, Dione D, Dobrucki LW, Mekkaoui C, Brennan MP, Hu X, Hawley C, Sinusas AJ. Hotspot quantification of myocardial focal tracer uptake from molecular targeted SPECT/CT images: canine validation. Proceedings of the SPIE 20086915:69150N1-8. 2008

  • [18F]Fluorodeoxyglucose as a memory marker of transient myocardial ischaemia.

    Abbott BG, Liu YH, Arrighi JA. [18F]Fluorodeoxyglucose as a memory marker of transient myocardial ischaemia. Nuclear Medicine Communications 2007, 28:89-94. 2007

  • A new method for hot-spot quantification of hybrid SPECT/CT cardiac images: methodology and preliminary phantom validation

    Liu YH, Fernando GP, Sinusas AJ. A new method for hot-spot quantification of hybrid SPECT/CT cardiac images: methodology and preliminary phantom validation. IEEE Trans Nucl Sci 200653:2814-2821. 2006

  • Aperture collimation correction and maximum-likelihood image reconstruction for near-field coded aperture imaging of single photon emission computerized tomography.

    Mu Z, Liu YH. Aperture collimation correction and maximum-likelihood image reconstruction for near-field coded aperture imaging of single photon emission computerized tomography. IEEE Transactions On Medical Imaging 2006, 25:701-11. 2006

See list of PubMed publications

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Contact Info

Yi-Hwa Liu, PhD
Mailing Address
Internal MedicinePO Box 208056
333 Cedar Street, Dana-3

New Haven, CT 06520-8056

Curriculum Vitae