Contact Info

Susan Kaech, PhD
Lab Location
Kaech LabThe Anlyan Center
300 Cedar Street, Ste S640

New Haven, CT 06519
Mailing Address
PO Box 208011
300 Cedar Street

New Haven, CT 06520

Kaech lab

Formation of memory T cells following infection.

Upon infection, naïve T cells become activated and proliferate and differentiate into a heterogeneous population of effector T cells. Most of the effector T cells terminally differentiate into effector T cells (blue cells) that protect against the current infection, but lose potential to develop into memory T cells. A smaller subset of effector T cells persist to develop into different types of memory T cells such as effector memory T (TEM) cells (red), central memory T (TCM) cells (yellow) and resident memory T (TRM) cells (green). These different populations of memory T cells form a tiered defense system. Figure modified from: Cui W and Kaech SM. Transcriptional Regulation of Effector and Memory CD8 T cell fates. Nat Rev Immunol 12:749-61 (2012).